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J-GLOBAL ID：201002289103439356   Reference number：10A0950417

Bisphenol A Downregulates Akt Signaling and Inhibits Adiponectin Production and Secretion in 3T3-L1 Adipocytes

3T3-L1脂肪細胞ではビスフェノールAはAktシグナル伝達を下方制御しアディポネクチンの産生と分泌を阻害する

Author (7)： KIDANI Teruki (Dep. of Bone and Joint Surgery, Ehime Univ. Graduate School of Medicine.) ,  KAMEI Setsuya (Dep. of Bone and Joint Surgery, Ehime Univ. Graduate School of Medicine.) ,  MIYAWAKI Joji (Dep. of Bone and Joint Surgery, Ehime Univ. Graduate School of Medicine.) ,  AIZAWA Junichi (Dep. of Bone and Joint Surgery, Ehime Univ. Graduate School of Medicine.) ,  AIZAWA Junichi (Dep. of Medical Technol., Fac. of Health Sciences, Ehime Prefectural Univ. of Health Sciences.) ,  SAKAYAMA Kenshi (Dep. of Bone and Joint Surgery, Ehime Univ. Graduate School of Medicine.) ,  MASUNO Hiroshi (Dep. of Medical Technol., Fac. of Health Sciences, Ehime Prefectural Univ. of Health Sciences.)
Material： Journal of Atherosclerosis and Thrombosis (Web)  (J Atheroscler Thromb (Web))
Volume： 17  Issue： 8  Page： 834-843 (J-STAGE)  Publication year： 2010 
JST Material Number： U0153A  ISSN： 1880-3873  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *fat cell ,...
Semi thesaurus term： cellular signal transduction ,...

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JST classification (2)： Treatment for metabolic diseases,nutritional diseases.  (GD05030F) ,  Basic medicine on cardiovascular system  (GJ01020K)

Substance index (4)： Bisphenol A ,  Bisphenol B ,  4,4'-Ethylidenebisphenol ,  Bisphenol F

Reference (48)：

• 1) Ashby J, Tinwell H: Uterotrophic activity of bisphenol A in the immature rat. Environ Health Perspect, 1998; 106: 719-720
• 2) Krishman AV, Stathis P, Permuth S, Tokes L, Feldman D: Bisphenol A: An estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology, 1993; 132: 2279-2286
• 3) Brede C, Fjeldal P, Skjevrak I, Herikstad H: Increased mi-gration levels of bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushing. Food Ad-dit Contam, 2003; 20: 684-689
• 4) Welshons WV, Nagel SC, vom Saal FS: Large effects of small exposures. III. Endocrine mechanisms mediating ef-fects of bisphenol A at levels of human exposure. Endocri-nology, 2006; 147: S56-S69
• 5) Brotons JA, Olea-Serrano FF, Villalobos M, Pedraza V, Olea N: Xenoestrogens released from lacquer coatings in food cans. Environ Health Perspect, 1995; 103: 608-612

Terms in the title (9)： L1 ,  脂肪細胞 ,  ビスフェノールA ,  AKT ,  シグナル伝達 ,  下方制御 ,  アディポネクチン ,  分泌 ,  阻害