Rchr
J-GLOBAL ID：201101001943821642   Update date: Aug. 11, 2024

michikawa makoto

michikawa makoto
Affiliation and department：
The Nippon Dental University School of Life Dentistry at Niigata

About The Nippon Dental University School of Life Dentistry at Niigata


Research field  (4)： Basic brain sciences ,  Prosthodontics ,  Neurology ,  Neuroscience - general
Research keywords  (9)： 歯科疾患と認知症 ,  アルツハイマー病 ,  アポリポ蛋白E ,  血液診断マーカー ,  アミロイドβタンパク質 ,  アンギオテンシン変換酵素 ,  HDL産生 ,  コレステロール ,  リポ蛋白リパーゼ
Research theme for competitive and other funds  (30)：
  • 2024 - 2028 加齢における慢性ストレスでの口腔環境の網羅的解析
  • 2020 - 2023 Gerontological investigation of microbiome: a longitudinal estimation study
  • 2020 - 2023 タウタンパク質のリン酸化におけるATBF1機能解析
  • 2020 - 2023 口腔細菌叢・歯周病原細菌を標的とした認知症対策の可能性の検討
  • 2020 - 2023 Study to establish a diagnostic blood marker and develop a diagnosis kit for early Alzheimer's disease
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Papers (153)：
  • Takashi Sakurai, Taiki Sugimoto, Hiroyasu Akatsu, Takehiko Doi, Yoshinori Fujiwara, Akihiro Hirakawa, Fumie Kinoshita, Masafumi Kuzuya, Sangyoon Lee, Nanae Matsumoto, et al. Japan-Multimodal Intervention Trial for the Prevention of Dementia: A randomized controlled trial. Alzheimer's and Dementia. 2024. 20. 6. 3918-3930
  • Mona Abdelhamid, Cha Gyun Jung, Chunyu Zhou, Rieko Inoue, Yuxin Chen, Yoshiki Sento, Hideki Hida, Makoto Michikawa. Potential Therapeutic Effects of Bifidobacterium breve MCC1274 on Alzheimer’s Disease Pathologies in AppNL-G-F Mice. Nutrients. 2024. 16. 4
  • Abu Zaffar Shibly, Abdullah Md Sheikh, Makoto Michikawa, Shatera Tabassum, Abul Kalam Azad, Xiaojing Zhou, Yuchi Zhang, Shozo Yano, Atsushi Nagai. Correction to: Analysis of Cerebral Small Vessel Changes in AD Model Mice (Biomedicines, (2022), 11, 1, (50), 10.3390/biomedicines11010050). Biomedicines. 2024. 12. 1
  • Tomohisa Nakamura, Tadahiro Hashita, Yuxin Chen, Yuan Gao, Yang Sun, Sadequl Islam, Hiroyuki Sato, Yasuyuki Shibuya, Kun Zou, Tamihide Matsunaga, et al. Aβ42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood-brain barrier model. Molecular Brain. 2023. 16. 1
  • Yuxin Chen, Chunyu Zhou, Mona Abdelhamid, Cha Gyun Jung, Makoto Michikawa. Inhibition of Sirt2 Decreases ApoE Secretion in Astrocytes and Microglial Cells. Journal of Biochemistry. 2023. 174. 5. 409-420
ｍore...
MISC (128)：
  • Yang Sun, Sadequl Islam, Makoto Michikawa, Kun Zou. Presenilin: A Multi-Functional Molecule in the Pathogenesis of Alzheimer’s Disease and Other Neurodegenerative Diseases. International Journal of Molecular Sciences. 2024. 25. 3
  • 鄒鶤, 高原, 孫陽, イスラム サデクル, 中村知寿, 富田泰輔, 道川誠. プレセニリン1欠損/変異はACEのAβ42変換活性を阻害する. 日本生化学会大会(Web). 2023. 96th
  • Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Arshad Ali Noorani, Tong Li, Philip C Wong, Noriyuki Kimura, Etsuro Matsubara, Kensaku Kasuga, et al. Presenilin is essential for ApoE secretion, a novel role of presenilin involved in Alzheimer's disease pathogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022. 42. 8. 1574-1586
  • 高原, 孫陽, SADEQUL Islam, 中村知寿, 富田泰輔, 鄒鶤, 道川誠. プレセニリン1欠損がACEのAβ変換活性に及ぼす影響. 日本神経化学会大会抄録集(Web). 2022. 65th
  • イスラム サデクル, 孫陽, 高原, 中村知寿, ARSHAD Ali Noorani, 木村成志, 松原悦郎, 春日健作, 池内健, 富田泰輔, et al. プレセニリンはApoEの分泌に必須である. Dementia Japan. 2022. 36. 4
ｍore...
Professional career (1)：
  • 医学 (東京医科歯科大学)
Work history (7)：
  • 2023/04 - 現在 日本歯科大学新潟生命歯学部 高齢者医療学
  • 2022/04 - 2023/03 名古屋市立大学 副学長(兼任)
  • 2012/04 - 2023/03 Nagoya City University Graduate School of Medical Sciences Department of Biochemistry Professor
  • 2017/04 - 2021/03 Nagoya City University Graduate School of Medical Sciences Dean
  • 2005/10 - 2012/03 国立長寿医療研究センター アルツハイマー研究部 部長
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