Rchr
J-GLOBAL ID：201101006879731121
Update date: May. 31, 2024
Sekimoto Takayuki
セキモト タカユキ | Sekimoto Takayuki
Affiliation and department：
Research field (2)：
Tumor diagnostics and therapeutics
, Molecular biology
Research keywords (10)：
Oncogenesis
, Cell senescence
, DNA repair
, DNA damage
, genomic instability
, Translesion DNA synthesis
, Y-family Polymerase
, Oncogene induced replication stress
, DNA damage response
, Heat shock response
Research theme for competitive and other funds (10)：
- 2021 - 2024 Mycが誘導する複製・転写ストレスの増強による治療ーG4リガンドを中心に
- 2018 - 2021 Development of new cancer therapy targeting the oncogene-induced replication stress response pathway.
- 2015 - 2018 Analysis of oncogene-induced replication stress response patyways
- 2015 - 2018 The role of Y-family polymerase in aberrant DNA replication and genomic instability
- 2012 - 2015 Analysis of replication stress responses caused by oncogenic signals
- 2012 - 2014 発がんシグナルが誘導する細胞老化とゲノム不安定性の分子機構
- 2011 - 2014 Roles of replication stress for cellular senescence and genome instability in preneoplastic lesions
- 2011 - 2012 前癌病変における細胞老化とゲノム不安定性
- 2010 - 2012 Analysis of the regulatory mechanisms of Y-family DNA polymerases and its roles in precancerous lesions
- 2008 - 2011 New understanding and therapeutics of hematopoietic diseases-from a viewpoint of regulatory mechanisms of replicative stress
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Papers (8)：
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Kiminori Kurashima, Takayuki Sekimoto, Tsukasa Oda, Tsuyoshi Kawabata, Fumio Hanaoka, Takayuki Yamashita. Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress. Journal of Cell Science. 2018. 131. 12. jcs212183-jcs212183
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Tsukasa Oda, Takayuki Sekimoto, Kiminori Kurashima, Mitsuaki Fujimoto, Akira Nakai, Takayuki Yamashita. Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. Journal of Cell Science. 2018. 131. 9. jcs210724-jcs210724
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Takayuki Sekimoto, Tsukasa Oda, Kiminori Kurashima, Fumio Hanaoka, Takayuki Yamashita. Both High-Fidelity Replicative and Low-Fidelity Y-Family Polymerases Are Involved in DNA Rereplication. Molecular and Cellular Biology. 2015. 35. 4. 699-715
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F. Mayca Pozo, T. Oda, T. Sekimoto, Y. Murakumo, C. Masutani, F. Hanaoka, T. Yamashita. Molecular Chaperone Hsp90 Regulates REV1-Mediated Mutagenesis. Molecular and Cellular Biology. 2011. 31. 16. 3396-3409
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Takayuki Sekimoto, Tsukasa Oda, Franklin Mayca Pozo, Yoshiki Murakumo, Chikahide Masutani, Fumio Hanaoka, Takayuki Yamashita. The Molecular Chaperone Hsp90 Regulates Accumulation of DNA Polymerase η at Replication Stalling Sites in UV-Irradiated Cells. Molecular Cell. 2010. 37. 1. 79-89
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MISC (7)：
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Takayuki Sekimoto, Tsukasa Oda, Kiminori Kurashima, Fumio Hanaoka, Takayuki Yamashita. Y-family polymerases are involved in oncogene-induced aberrant replication. DNA REPAIR. 2015. 28. 144-144
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関本 隆志. 前がん病変における細胞老化とゲノム不安定性. 上原記念生命科学財団研究報告集. 2013. 27. 1-5.
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Takayuki Yamashita, Tsukasa Oda, Takayuki Sekimoto. Translesion DNA Synthesis and Hsp90. Genes and Environment. 2012. 34. 2. 89-93
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山下孝之, 小田司, 関本隆志. Fanconi貧血の分子病態-最近の進歩. 臨床血液. 2009. 50. 7. 538-546
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山下孝之, 小田司, 関本隆志. Fanconi貧血-ゲノム損傷ストレスと造血幹細胞の老化-. 日本臨牀. 2008. 66. 3. 477-482
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Lectures and oral presentations (53)：
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Myc誘導性複製ストレスにおけるグアニン四重鎖構造は治療標的になり得るか
(第43回日本分子生物学会 2020)
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がん遺伝子誘導性複製ストレスにおけるグアニン四重鎖構造の役割
(第42回日本分子生物学会 2019)
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がん遺伝子誘導性Replication Stress(RS)への応答におけるRAD51を介するフォーク保護機構の役割
(第41回日本分子生物学会年会 2018)
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Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress
(The 4th IMCR Symposium on Endocrine and Metabolism: At the Cutting Edge of Metabolic Regulation Research 2018)
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53BP1はHSF1抑制で誘導される細胞老化に関与する
(第77回日本癌学会学術総会 2018)
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Education (3)：
- 2002 - 2006 Kanazawa University Graduate School of Natural Science and Technology Division of Life Sciences
- 1999 - 2002 Kanazawa University National Science and Technology
- 1995 - 1999 Kanazawa University Faculty of Science Department of Biology
Professional career (1)：
- Doctor of Science (Kanazawa University Graduate School)
Work history (3)：
- 2010/05 - 現在 Institute for Molecular and Cellular Regulation, Gunma University Laboratory of Molecular genetics Assistant Professor
- 2008/04 - 2010/04 Institute for Molecular and Cellular Regulation, Gunma University Laboratory of Molecular genetics Postdoctoral fellow
- 2006/07 - 2008/03 Institute for Molecular and Cellular Regulation, Gunma University Laboratory of Molecular genetics
Awards (1)：
- 2016 - 日本分子生物学会 優秀ポスター賞 Y-familyポリメラーゼPolηとエンドヌクレアーゼMus81-Eme2複合体は段階的に協調してc-MYCがん遺伝子誘導性複製ストレスを抑制する
Association Membership(s) (2)：
Japanese Cancer Association
, The Molecular Biology Society of Japan
