Rchr
J-GLOBAL ID：201101011051005633
Update date: Oct. 08, 2025
Yamaguchi Satoshi
ヤマグチ サトシ | Yamaguchi Satoshi
Affiliation and department：
Job title：
Professor
Research field (5)：
Polymer chemistry
, Biomedical engineering
, Applied biofunctional and bioprocess engineering
, Biochemistry
, Medical biochemistry
Research keywords (6)：
合成生物化学
, 化学生物工学
, バイオマテリアル
, 1細胞生物学
, 細胞工学
, 蛋白質工学
Research theme for competitive and other funds (23)：
- 2024 - 2030 2細胞計測を用いた細胞間相互作用の画像・遺伝子統合解析
- 2024 - 2028 がん免疫の1細胞解析のための光応答性細胞コロシアムの開発
- 2024 - 2027 Development of a Process for Integrative Single-Cell Analysis of Genes Related to Cancer Immunity
- 2025 - 2026 圧力駆動薄膜を用いた皺形成制御型培養皮膚の創製
- 2021 - 2024 標的分泌物応答性1細胞アレイを用いた分泌細胞分取システムの開発
- 2021 - 2022 細胞の配置と回収の両方を光制御可能な二波長応答型細胞固定化表面の開発
- 2019 - 2022 細胞資源を活用する細胞間相互作用の精密創成技術
- 2019 - 2022 An analytic method for the intracellular domain of cell membranes by microfluidic disruption
- 2016 - 2020 光応答性細胞固定化剤表面を用いた1細胞操作技術の開発と応用
- 2015 - 2018 Development and its applications of a versatile system for single cell array, imaging analysis and selective cell collection
- 2015 - 2018 Multi functionalization of proteins by sterically bulky caging
- 2012 - 2015 Development of technologies for maintaining undifferentiated state and inducing growth and differentiation of human iPS cell by using chimeric receptor
- 2012 - 2014 Development of selective cell collection method using photo-degradable PEG-lipid
- 2012 - 2014 Stimuli-responsive nano-shells for caging living cells
- 2012 - 2013 スプリット蛍光タグを用いた細胞内蛋白質の酵素標識法の開発
- 2011 - 2012 光分解性ポリエチレングリコール脂質を用いた細胞選択技術の開発
- 2011 - 2012 Turn-on split fluorescent tag responding to enzymatic ligation
- 2009 - 2010 部位特異的機能性分子修飾による蛋白質の細胞内導入および細胞機能の変換技術の開発
- 2009 - 2010 超分子化学/遺伝子工学融合による人工アロステリック酵素の開発
- 2009 - 2010 Regulating cell function by introduction of the proteins enzymatically modified with synthetic functional molecules into cell membrane or cytoplasm
- 2006 - 2009 Development of artificial receptor-based amplification system of dendritic cells for cancer therapy
- 2007 - 2008 Development of artificial chaperone molecules by combinatorial approach for applications to proteomic researches
- 2007 - 2008 細胞内情報伝達分子および分子間相互作用の時空間的イメージング技術の開発
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Papers (80)：
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Yuki Umeda, Hao Zhu, Satoshi Yamaguchi, Sho Nakamura, Masato Takada, Shin Izuta, Akimitsu Okamoto. Photoactivatable Alkyne Tag for Photolabeling Biomolecules in Living Cells. ChemBioChem. 2025. 26. 17
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Yuki Umeda, Shinya Yamahira, Koki Nakamura, Tomoko Takagi, Tomoko Suzuki, Kae Sato, Yusuke Hirabayashi, Akimitsu Okamoto, Satoshi Yamaguchi. Microfluidic cell unroofing for the in situ molecular analysis of organelles without membrane permeabilization. Lab on a Chip. 2025. 25. 9. 2222-2233
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Ryota SASAKI, Chiharu MORIYAMA, Junhoo CHOI, Satoshi YAMAGUCHI, Keiichi NAKAGAWA. Analysis of Vaporization Behavior of Phase-change Nano-droplets Using a Negative Pressure Component of Laser-induced Shockwave. Advanced Biomedical Engineering. 2025. 14. 62-69
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Shinya Yamahira, Hidefumi Mitsuno, Misato Yamaoka, Teruyuki Nagamune, Akimitsu Okamoto, Ryohei Kanzaki, Satoshi Yamaguchi. Odorant-sensing cell micropatterns for odor discrimination. Biosensors and Bioelectronics: X. 2024. 18. 100473
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Satoshi Yamaguchi, Miho Kisaka, Kotaro Higashi, Ayumu Ishijima, Takashi Azuma, Keiichi Nakagawa, Yoshikazu Shibasaki, Ichiro Sakuma, Akimitsu Okamoto. Cytosolic protein delivery using ultrasound-guided vaporization of perfluorocarbon nano-droplets. Biotechnology Journal. 2023. 18. 7. 2300018
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MISC (83)：
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山口哲志, 山平真也. がん細胞傷害性の1細胞解析技術の開発. 生物工学会誌. 2023. 101. 12. 630-633
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山口哲志. 特集 革新的ながん免疫療法の実現を目指す分子技術開発の最前線ー 特集によせて. 生物工学会誌. 2023. 101. 12. 616-616
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増井周造, 門屋祥太郎, 道畑正岐, 小阪高広, 山口哲志, 岡本晃充, 高橋哲. 局在光制御によるセルインマイクロファクトリに関する基礎的研究(第8報)-ストレプトアビジン,ビオチン相互作用を用いたマイクロ粒子接着-. 精密工学会大会学術講演会講演論文集(CD-ROM). 2022. 2022
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瀬川拓未, 石島歩, 佐伯峻生, 島田啓太郎, SONG Hang, 山口哲志, 佐久間一郎, 小林英津子, 中川桂一. Proposal of ultrafast laser diffractometry for analyzing bubble dynamics with sub-diffraction-limit resolution. 衝撃波シンポジウム講演論文集(CD-ROM). 2022. 2021
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山口哲志. 細胞の付着と脱離を光制御できる細胞培養基板. バイオインダストリー. 2021. 38. 26-33
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Patents (15)：
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単一細胞固定化用マイクロウェルアレイ
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細胞塊を培養及び回収するための表面修飾基材
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細胞特性の評価方法
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光応答性細胞固定化剤
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光分解性細胞固定化剤
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Books (4)：
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Cell-Based Microarrays, Methods in Molecular Biology 706 (E. Palmer ed.)
Human Press 2010
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バイオ医薬の開発技術とシーズ、山本重夫 監修
シーエムシー出版 2009
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Nanotechnology in Carbohydrate Chemistry (H Yuasa ed.)
Transworld research network 2006
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Bioseparation Engineering, I. Endo, T. Nagamune, S. Katoh and T. Yonemoto(Editors)
Elsevier Science B. V. 1999
Lectures and oral presentations (95)：
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刺激分解性ビオチン化試薬を用いた細胞内タンパク質送達
(日本化学会第102春季年会 2022)
-
Single-cell analysis of immune cell cytotoxicity using a photo-reactive surface
(2022)
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細胞膜のマイクロ流体剥離技術を用いた細胞内1細胞解析
(化学工学会第87年会 2022)
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Photo-reactive surface for the single cell analysis of intercellular communication
(Pacifichem 2021 2021)
-
Photo-activatable poly(ethylene glycol)-lipid surface for single-cell manipulation
(Pacifichem 2021 2021)
ｍore...
Education (2)：
- 1999 - 2004 The University of Tokyo School of Engineering Department of Chemistry and Biotechnology
- 1995 - 1999 The University of Tokyo Faculty of Engineering Department of Chemistry and Biotechnology
Professional career (1)：
- PhD (Engineering) (The University of Tokyo)
Work history (10)：
- 2024/10 - 現在 東京大学 生産技術研究所 特任研究員(兼任)
- 2024/01 - 現在 Osaka University The Institute of Scientific and Industrial Research Professor
- 2022/04 - 2023/12 Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo Associate Professor
- 2019/08 - 2022/03 The University of Tokyo Research Center for Advanced Science and Technology
- 2013/03 - 2019/07 The University of Tokyo Research Center for Advanced Science and Technology Lecturer
- 2009/01 - 2013/01 The University of Tokyo School of Engineering Assistant Professor
- 2007/04 - 2008/12 The University of Tokyo School of Engineering Project Assistant Professor
- 2006/04 - 2007/03 The University of Tokyo School of Engineering Project Assistant Professor
- 2005/08 - 2006/03 Kyoto University School of Engineering Postdoctoral fellow
- 2004/04 - 2005/07 Kyushu University Institute for Materials Chemistry and Engineering Postdoctoral fellow
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Committee career (7)：
Awards (6)：
Association Membership(s) (6)：
THE SOCIETY OF POLYMER SCIENCE, JAPAN
, フロンティア生命化学研究会
, 酵素工学研究会
, 日本生物工学会
, 日本化学会
, 化学工学会
