Harada Takayuki

Affiliation and department：
Job title： Department Head
Homepage URL (2)： http://www.igakuken.or.jp/retina/ , http://www.igakuken.or.jp/english/project/detail/pro26/retina2.html

Research field (2)： Neuroscience - general , Ophthalmology

Research keywords (23)： GLAST , MOCA , グリア細胞 , 緑内障 , 発生・分化 , 網膜変性疾患 , 虚血 , グルタミン酸毒性 , 軸索伸長 , 遺伝子 , 眼科学 , 軸索再生 , グルタミン酸 , 視細胞 , 緑発現制御 , 網膜発生 , グリア , 神経細胞死 , 神経保護 , 神経栄養因子 , 神経再生 , 神経変性疾患 , 網膜

Research theme for competitive and other funds (17)：

2021 - 2024 視覚経路の再構築による失明からの回復を目指した治療法の開発
2021 - 2024 Mechanisms underlying retinal glia-mediated glaucoma
2021 - 2024 Investigation into neuronal repair and functional recovery in neurodegenerative diseases
2019 - 2024 Development of new glaucoma therapy using effective delivery of factors associated with neuroprotection and axon regeneration
2018 - 2020 Optogeneticsによる神経変性疾患モデルの作製と治療研究

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Papers (148)：

Kazuhiko Namekata, Naoki Tsuji, Xiaoli Guo, Euido Nishijima, Sari Honda, Yuta Kitamura, Atsushi Yamasaki, Masamichi Kishida, Jun Takeyama, Hirokazu Ishikawa, et al. Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation. Cell death discovery. 2023. 9. 1. 166-166
Naoki Kiyota, Kazuhiko Namekata, Euido Nishijima, Xiaoli Guo, Atsuko Kimura, Chikako Harada, Toru Nakazawa, Takayuki Harada. Effects of constitutively active K-Ras on axon regeneration after optic nerve injury. Neuroscience letters. 2023. 799. 137124-137124
Euido Nishijima, Sari Honda, Yuta Kitamura, Kazuhiko Namekata, Atsuko Kimura, Xiaoli Guo, Yuriko Azuchi, Chikako Harada, Akira Murakami, Akira Matsuda, et al. Vision protection and robust axon regeneration in glaucoma models by membrane-associated Trk receptors. Molecular therapy : the journal of the American Society of Gene Therapy. 2022. 31. 3. 810-824
Youichi Shinozaki, Alex Leung, Kazuhiko Namekata, Sei Saitoh, Huy Bang Nguyen, Akiko Takeda, Yosuke Danjo, Yosuke M Morizawa, Eiji Shigetomi, Fumikazu Sano, et al. Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy. Science advances. 2022. 8. 44. eabq1081
Xiaoli Guo, Atsuko Kimura, Kazuhiko Namekata, Chikako Harada, Nobutaka Arai, Kohsuke Takeda, Hidenori Ichijo, Takayuki Harada. ASK1 signaling regulates phase-specific glial interactions during neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America. 2022. 119. 6

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MISC (109)：

HAMADA Kentaro, SHINOZAKI Yoichi, SHINOZAKI Yoichi, NAMEKATA Kazuhiko, OHNO Nobuhiko, OHNO Nobuhiko, SEGAWA Takahiko, HARADA Takayuki, KASHIWAGI Kenji, KOIZUMI Shuichi, et al. P2Y₁ receptor is a novel target for anti-glaucoma treatment. 日本薬理学会年会(Web). 2021. 94th
篠崎陽一, 篠崎陽一, 行方和彦, 柏木賢治, 大野伸彦, 大野伸彦, 繁冨英治, 繁冨英治, 原田高幸, 小泉修一, et al. Astrocytes trigger early remodeling of optic nerve head in NTG model mouse. 日本眼科学会雑誌. 2021. 125
濱田健太郎, 篠崎陽一, 篠崎陽一, 行方和彦, 大野伸彦, 大野伸彦, 原田高幸, 柏木賢治, 小泉修一, 小泉修一. P2Y1 receptor loss causes ocular hypertension and loss of retinal ganglion cells. 日本眼科学会雑誌. 2021. 125
HAMADA Kentaro, SHINOZAKI Youichi, SEGAWA Takahiro, NAMEKATA Kazuhiko, OHNO Nobuhiko, OHNO Nobuhiko, HARADA Takayuki, KASHIWAGI Kenji, KOIZUMI Schuichi. Loss of P2Y₁ receptor causes ocular hypertension and glaucoma-like phenotype in mice. 日本薬理学会年会(Web). 2020. 93rd
HAMADA Kentaro, SHINOZAKI Yoichi, SHINOZAKI Yoichi, NAMEKATA Kazuhiko, OHNO Nobuhiko, OHNO Nobuhiko, SEGAWA Takahiro, HARADA Takayuki, KASHIWAGI Kenji, KOIZUMI Schuichi, et al. Hypertensive glaucoma is induced by impairment of P2Y1 receptor function. 日本神経化学会大会抄録集(Web). 2020. 63rd

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Professional career (1)：

M.D. Ph.D.

Work history (6)：

2024/04 - 現在東京都医学総合研究所疾患制御研究分野分野長
2020/04 - 現在東京都医学総合研究所病院等連携支援センターセンター長
2011/04 - 現在東京都医学総合研究所視覚病態プロジェクトプロジェクトリーダー
2015/04 - 2020/03 Tokyo Metropolitan Institute of Medical Science Department of Sensory and Motor Systems Department Head
2004/01 - 2011/03 東京都神経科学総合研究所分子神経生物学研究部門部門長

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