Nomura Tadashi

ノムラタダシ | Nomura Tadashi

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://tadnom.jimdo.com

Research field (2)： Evolutionary biology , Developmental biology

Research keywords (17)：包括脳ネットワーク , 嗅皮質 , 神経幹細胞 , 全胚培養 , 神経細胞 , アストロサイト , ephrin-A5 , 細胞増殖 , 嗅球 , 器官培養 , Pax6遺伝子 , 遺伝子導入 , 脊椎動物 , 細胞移植 , 大脳皮質 , 哺乳類 , 神経細胞移動

Research theme for competitive and other funds (33)：

2022 - 2027 哺乳類特異的な皮質間投射神経回路の進化に寄与した転写制御メカニズムの解明
2024 - 2025 脂質代謝に注目した長期ライフステージにおける運動器疾患の病態解明
2022 - 2025 化石人類特異的なアミノ酸変化によるヒト表現型進化の再構築
2023 - 2024 発生制御タンパク質の非同義置換が与えるヒトの解剖学的変化と病態解析
2021 - 2024 Exploring evolutionary origin of excitatory neurons by multi-hierarchical abalyses

2020 - 2021 Changes in neuronal morphology by temporal regulations of Wnt signaling

2018 - 2020 Molecular mechanisms of species-specific temperature-dependency and compensation of Notch signaling

2017 - 2020 Exploring the evolutionary origin of mammalian pallial regions by comparative developmental analysis

2016 - 2018 Analysis of function of glycogen metabolism in the neural stem cell

2016 - 2018 Exploring molecular mechanisms regulate temperature-dependent and -independent developmental timing

2017 - 2018 神経細胞の形態変化に着目した哺乳類大脳皮質進化機構の解明

2014 - 2017 Developmental plan in reptilian telencephalon: with reference to the evolution of two distinct brain centers

2013 - 2016 The role of Nkx2.1 in differentiation of NG2 cell-derived astrocyte

2014 - 2016 実験進化発生学的解析による共感性回路の起源の探索

2014 - 2016 Establishment of transgenic reptiles by targeting spermatogonial stem cells

2012 - 2016 進化的・構成的アプローチによる哺乳類型大脳皮質層構造の再設計

2015 - 2016 ゲノム挿入ベクターの導入による成体神経幹細胞の可視化と動態操作

2012 - 2015 哺乳類成体神経幹細胞ニッチの形成機構の解明

2012 - 2014 Evolution of cortical intermediate progenitors and Tbr2 gene functions

2012 - 2013 成体脊髄神経幹細胞における受容体型チロシンキナーゼEphBの機能解析

2011 - 2012 分子発生学的手法による摂食障害マウスの病態解析

2011 - 2012 成体脊髄神経幹細胞の増殖と分化制御メカニズムの解明

2011 - 2012 改変型電気穿孔法を用いた成体神経幹細胞への遺伝子導入法の確立

2012 - 2012 摂食障害モデルマウスAnxの発生遺伝学的解析

2010 - 2012 Comprehensive analysis of neural differentiation programs in the neural circuit formation

2005 - 2009 Study on molecular mechanisms for regulating proliferation and differentiation of embryonic neural stem cells

2006 - 2007 大脳皮質アストロサイトに発現するPax6遺伝子と脳高次機能との関連を探る

2004 - 2005 Pax6変異ラット脳に見られるアストロサイトの異常と神経機能異常との関連

2004 - 2005 大脳皮質領野形成過程におけるPax6遺伝子の機能解析

2002 - 2003 哺乳類終脳の発生過程における領域決定の機構を探る

2002 - 2003 哺乳類嗅球発生におけるPax6遺伝子の機能解析

2001 - 2002 哺乳類嗅球を構成する神経前駆細胞の移動機構を探る

2001 - 2001 哺乳類嗅球発生におけるPax6遺伝子の機能を探る

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Papers (56)：

Ako Agata, Tadashi Nomura. Thermal adaptations in animals: genes, development, and evolution. Thermal Biology: Temperature Sensing and Temperature-responding Systems (Advances in Experimental Medicine and Biology, 1461). 2024
Masahito Ishiyama, Hitoshi Gotoh, Souichi Oe, Tadashi Nomura, Masaaki Kitada, Katsuhiko Ono. Glycogenolysis-Induced Astrocytic Serping1 Expression Regulates Neuroinflammatory Effects on Hippocampal neuron. Molecular neurobiology. 2024
Ako Agata, Satoshi Ohtsuka, Ryota Noji, Hitoshi Gotoh, Katsuhiko Ono, Tadashi Nomura. A Neanderthal/Denisovan GLI3 variant contributes to anatomical variations in mice. Frontiers in Cell and Developmental Biology. 2023. 11. 1247361
Katsuhiko Ono, Hitoshi Gotoh, Tadashi Nomura, Tsuyoshi Morita, Otto Baba, Mami Matsumoto, Sei Saitoh, Nobuhiko Ohno. Ultrastructural characteristics of oligodendrocyte precursor cells in the early postnatal mouse optic nerve observed by serial block-face scanning electron microscopy. PloS one. 2022. 17. 12. e0278118
Hitoshi Gotoh, Kohei Maruyama, Kengo Yoshii, Nao Yamauchi, Tadashi Nomura, Satoshi Ohtsuka, Ryuichi Shirasaki, Hirohide Takebayashi, Katsuhiko Ono. Disruption of the anterior commissure in Olig2 deficient mice. The European journal of neuroscience. 2022. 57. 1. 5-16

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MISC (58)：

野村真. 小野勝彦教授のご退任に寄せて. Studia humana et naturalia / 京都府立医科大学医学部医学科 (教養教育) 編. 2022. 56. 1-3
野地亮太, 野村真. 爬虫類を用いた進化医学的アプローチ : 非モデル生物を用いた分子遺伝学の確立. Studia humana et naturalia / 京都府立医科大学医学部医学科 (教養教育) 編. 2022. 56. 55-62
Tadashi Nomura. Regulations of temperature-dependent Notch signaling underlie species-specific brain development. Experimental Medicine. 2022. 40. 8. 1304-1307
Chisato Nakamori, Hitoshi Gotoh, Tadashi Nomura, Katsuhiko Ono. The role of glial cells in feeding behaviors: History and progress report. Studia humana et naturalia. 2020. 54. 89-95
野村真. 羊膜類の脳進化機構の解明ー遺伝子発現機構の可塑性と細胞型の相同性. 生化学. 2020. 92. 2/3. 200-209

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Lectures and oral presentations (32)：

哺乳類大脳皮質の起源と進化過程の解明
(2024)
Genetic and developmental programs underlying mammalian and human evolution
(Korea Brain Research Institute Seminar 2024)
Genetic and developmental bases for mammalian and human-specific anatomical traits
(15th Korea- Japan Neurodevelopmental Biology Meeting 2024)
Conserved developmental mechanisms for the interhemispheric connection preceded the evolution of the mammalian corpus callosum
(2024)
Genetic and developmental bases underlying mammalian-specific anatomical traits
(The 7th spring meeting of Neurodevelopmental research 2024)

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Education (2)：

- 2000 Nagoya University
- 1995 Yamagata University Faculty of Science

Professional career (1)：

Work history (10)：

2023/05 - 現在 Kyoto Institute of Technology Applied Biology Professor
2011/04 - 2024/03 Graduate School of Medicine, Kyoto Prefectural University of Medicine Associate Proffessor
2012/10 - 2016/03 JST PRESTO Researcher
2010/09 - 2011/03 CMB, Karolinska Institute Senior Researcher
2007/09 - 2010/08 CMB, Karolinska Institute Postdoctoral Researcher

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Awards (2)：

2010/11 - Best Poster Prize, "Solbacka" Karolinska Institute CMB & Ludwig symposium
2007/01 - School of Medicine, Tohoku University Young Investigator Award

Association Membership(s) (4)：

北米神経科学会 , 日本分子生物学会 , 日本神経科学会 , 日本発生生物学会

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