Rchr
J-GLOBAL ID：201101033614192854   Update date: Apr. 23, 2025

Gotoh Yukiko

ゴトウ ユキコ | Gotoh Yukiko
Affiliation and department：
The University of Tokyo Graduate School of Pharmaceutical Sciences

About The University of Tokyo Graduate School of Pharmaceutical Sciences


Homepage URL  (1)： http://kaken.nii.ac.jp/ja/r/70252525
Research field  (5)： Developmental biology ,  Cell biology ,  Systems genomics ,  Genomics ,  Neuroscience - general
Research keywords  (35)： 神経幹細胞 ,  アポトーシス ,  MAPキナーゼ ,  細胞運動 ,  カスペース ,  ニューロン ,  がん遺伝子 ,  神経細胞 ,  PI3キナーゼ ,  細胞生存 ,  細胞死 ,  細胞極性 ,  上皮間葉転換 ,  Scratch ,  増殖因子 ,  ニューロンサブタイプ ,  包括脳ネットワーク」 ,  JNK ,  MST1 ,  MAPKK ,  p38 ,  Bax ,  PDK1 ,  Mdm2 ,  SEKI ,  XMEK2 ,  Ras ,  MST ,  Cdc42 ,  Rho ,  actin, ,  増殖シグナル伝達 ,  PAK ,  AKT ,  生存シグナル
Research theme for competitive and other funds  (31)：
  • 2024 - 2029 神経の長期記憶を司るエピコードの解読
  • 2022 - 2028 脳損傷による記憶障害メカニズムの解析
  • 2022 - 2025 新規3Dゲノム構造同定法に基づいたニューロン分化・可塑性制御機構の解明
  • 2019 - 2025 Regulation of embryonic neural stem cells and its relation to postnatal brain development and autism spectrum disorder
  • 2021 - 2022 Interplay of developmental clock and extracellular environment in brain formation
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Papers (182)：
  • Koki Nakamura, Saeko Aoyama-Ishiwatari, Takahiro Nagao, Mohammadreza Paaran, Christopher J Obara, Yui Sakurai-Saito, Jake Johnston, Yudan Du, Shogo Suga, Masafumi Tsuboi, et al. Mitochondrial complexity is regulated at ER-mitochondria contact sites via PDZD8-FKBP8 tethering. Nature communications. 2025. 16. 1. 3401-3401
  • Tomoya Kujirai, Kenta Echigoya, Yusuke Kishi, Mai Saeki, Tomoko Ito, Junko Kato, Lumi Negishi, Hiroshi Kimura, Hiroshi Masumoto, Yoshimasa Takizawa, et al. Structural insights into how DEK nucleosome binding facilitates H3K27 trimethylation in chromatin. Nature structural & molecular biology. 2025
  • Yan Wang, Yi Wang, Tomohiro Iriki, Eiichi Hashimoto, Maki Inami, Sota Hashimoto, Ayako Watanabe, Hiroshi Takano, Ryo Motosugi, Shoshiro Hirayama, et al. The DYT6 dystonia causative protein THAP1 is responsible for proteasome activity via PSMB5 transcriptional regulation. Nature communications. 2025. 16. 1. 1600-1600
  • Sarasa Yano, Natsu Asami, Yusuke Kishi, Ikuko Takeda, Hikari Kubotani, Yuki Hattori, Ayako Kitazawa, Kanehiro Hayashi, Ken-ichiro Kubo, Mai Saeki, et al. Propagation of neuronal micronuclei regulates microglial characteristics. Nature Neuroscience. 2025. 28. 3. 487-498
  • Yoshito Hirata, Hiroki Sugishita, Yukiko Gotoh. Reconstruction of 3D Chromosome Structure from Single-Cell Hi-C Data via Recurrence Plots. Methods in Molecular Biology. 2024. 263-268
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MISC (41)：
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Lectures and oral presentations  (531)：
  • Chromatin-Level Regulation of Neural Stem Cell Fate
    (Gordon Research Conference, Genome Architecture in Cell Fate and Disease 2025)
  • Gene regulation in response to neuronal activity
    (Neurogenomics Conference, Human Technopole 2025)
  • Regulation of neural stem-progenitor cell fate during mouse neocortical development
    (EMBO Workshop, Developmental timing across species: From mechanisms to evolutionary insights 2025)
  • 海馬ニューロンにおけるBDNF依存的な長期的遺伝子発現変動のメカニズムの解析
    (日本薬学会第145年会 2025)
  • Profiling of neutrophils predicts the survival fate upon lethal viral infection
    (The Second Joint Symposium of AMED SCARDA Japan Initiative for World-leading Vaccine Research and Development Centers 2025)
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Work history (4)：
  • 2017/10 - 現在 The University of Tokyo International Research Center for Neurointelligence Principal Investigator
  • 2013/10 - 現在 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 2005/04 - 2013/09 The University of Tokyo Institute of Molecular and Cellular Biosciences
  • 1998/04 - 2005/03 The University of Tokyo Institute of Molecular and Cellular Biosciences
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