Rchr
J-GLOBAL ID:201101035578577267
Update date: Sep. 26, 2024
Touhara Kazushige
トウハラ カズシゲ | Touhara Kazushige
Affiliation and department:
Homepage URL (1):
http://park.itc.u-tokyo.ac.jp/biological-chemistry/
Research field (5):
Biophysics
, Neuroscience - general
, Bioorganic chemistry
, Functional biochemistry
, Medical biochemistry
Research keywords (29):
包括脳ネットワーク
, 脳プロ
, ESP1
, 嗅覚レセプタ-
, c-Fos
, 遺伝子発現誘導
, ペプチド
, ショウジョウバエ
, リガンド
, 遺伝子発現制御
, アデノウイルス
, 誘引
, フェロモン受容体
, 精子
, センサー
, 情報伝達
, 再構成
, 構造決定
, カイコ
, Gタンパク質
, 嗅覚受容体
, カルシウム
, 昆虫
, 鋤鼻器官
, 嗅覚
, マウス
, 匂い
, 受容体
, フェロモン
Research theme for competitive and other funds (25):
- 2018 - 2023 Identification of primer pheromones in mammals and elucidation of a neural basis for the pheromone action
- 2019 - 2023 香りの機能拡張によるヒューメインな社会の実現
- 2015 - 2018 Elucidation of a transmitting mechanism of the information of odorants and pheromones, based on the fMRI analysis of the olfactory bulb and the higher-order brain regions and the behavior analysis
- 2015 - 2018 Integrative sensory evolution in primates revealed by population genetic analysis of olfactory, taste, and color vision receptor genes
- 2014 - 2017 MRI analysis of olfactory neurocircuits that discriminate odor and pheromone signals
- 2012 - 2017 Identification of natural ligands for olfactory receptors and elucidation of biological function
- 2012 - 2014 Elucidation of the mechanism of the specific interaction of a mouse peptide pheromone ESP1 and the class-C GPCR receptor
- 2010 - 2014 Evolutionary diversity and adaption of sensory genes evaluated for natural populations of primates
- 2011 - 2013 植物の匂い感覚メカニズムの解明
- 2012 - 2012 嗅覚受容体のナチュラルリガンドの同定とその生物学的機能の解明
- 2007 - 2011 Molecular mechanisms for recognition and signal transduction of sex-specific peptides in the mouse vomeronasal organ
- 2006 - 2010 Studies on odorant and pheromone receptor as a chemosensor for the external environmen
- 2006 - 2010 Molecular interaction and modal shift for cell sensors
- 2007 - 2008 マウスフェロモンファミリーとG蛋白質共役受容体の相互作用ネットワークに関する研究
- 2007 - 2007 マウスにおける性特異的ペプチドフェロモンの鋤鼻神経系での受容メカニズムの解明
- 2004 - 2006 マウスの不揮発性フェロモン物質の構造決定と受容体の同定
- 2001 - 2002 精子における嗅覚受容体様タンパク質の内在性リガンドの探索
- 2001 - 2001 多角的アプローチによる嗅覚情報伝達の総合的研究
- 2000 - 2001 幼若ホルモン受容体の探索
- 1999 - 2000 Reconstitution and visualization of odorant responses in olfactory neurons
- 1998 - 1999 Tyrosine phosphorylation and activation of PKC and its role in celluar regulation
- 1998 - 1998 PHドメイン結合物質によるPKB蛋白質リン酸化酵素の活性制御に関する研究
- 1997 - 1998 Analysis of an odorant receptor in olfactory network
- 1996 - 1996 PHドメインを含むGタンパク質共役型受容体キナーゼの機能解析
- 1996 - 1996 神経細胞におけるGタンパク質βγサブユニット・MAPキナーゼ・遺伝子発現系
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Papers (115):
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Ken Murata, Takumi Itakura, Kazushige Touhara. Neural basis for pheromone signal transduction in mice. Frontiers in Neural Circuits. 2024. 18
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Toshiki Okumura, Ikuhiro Kida, Atsushi Yokoi, Tomoya Nakai, Shinji Nishimoto, Kazushige Touhara, Masako Okamoto. Semantic context-dependent neural representations of odors in the human piriform cortex revealed by 7T MRI. Human Brain Mapping. 2024. 45. 6
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Miwa Masuda, Sayoko Ihara, Naoki Mori, Tetsuya Koide, Nobuhiko Miyasaka, Noriko Wakisaka, Keiichi Yoshikawa, Hidenori Watanabe, Kazushige Touhara, Yoshihiro Yoshihara. Identification of olfactory alarm substances in zebrafish. Current biology : CB. 2024. 34. 7. 1377-1389
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Nanaho Fukuda, Tomoyuki Fukuda, Piergiorgio Percipalle, Kanako Oda, Nobuyuki Takei, Kevin Czaplinski, Kazushige Touhara, Yoshihiro Yoshihara, Toshikuni Sasaoka. Axonal mRNA binding of hnRNP A/B is crucial for axon targeting and maturation of olfactory sensory neurons. Cell Reports. 2023. 42. 5. 112398-112398
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Satoshi Morinaga, Koji Nagata, Sayoko Ihara, Tomohiro Yumita, Yoshihito Niimura, Koji Sato, Kazushige Touhara. Structural model for ligand binding and channel opening of an insect gustatory receptor. Journal of Biological Chemistry. 2022
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MISC (154):
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伊原さよ子, 岡本雅子, 白須未香, 東原和成. 香りのヒューメインな有効活用に向けた嗅覚基礎研究の進展. アロマリサーチ. 2022. 23. 2. 3-8
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岡本雅子, 東原和成. Human Olfaction Has Full of ”Unknowns”: Approaches for its Study. 季刊香料. 2022. 293
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東原和成. 嗅覚研究に基づく香りの意義と応用. ファルマシア. 2021. 57. 3. 167-167
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板倉拓海, 東原和成. 嗅覚受容の分子メカニズム. Clinical Neuroscience. 2021. 39. 2. 154-158
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Mika Shirasu, Satomi Ito, Akihiro Itoigawa, Takashi Hayakawa, Kodzue Kinoshita, Isao Munechika, Hiroo Imai, Kazushige Touhara. Response to Kappeler. Current Biology. 2020. 30. 22. R1360
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