Rchr
J-GLOBAL ID：201101036663261801   Update date: Jan. 31, 2024

Nishitoh Hideki

ニシトウ ヒデキ | Nishitoh Hideki
Affiliation and department：
University of Miyazaki Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences

About University of Miyazaki Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences


Job title： professor
Homepage URL  (1)： http://www.med.miyazaki-u.ac.jp/2bio/index.html
Research field  (3)： Pathobiochemistry ,  Cell biology ,  Medical biochemistry
Research keywords  (32)： 包括脳ネットワーク ,  統合脳・病態脳 ,  再生療法 ,  一酸化窒素(NO) ,  骨形成たんぱく質 ,  遺伝子導入 ,  ASKファミリー ,  遺伝子治療 ,  硬組織再生 ,  自然免疫 ,  遺伝子活性化気質 ,  カルシウム ,  ASK2 ,  FRET ,  活性酸素種 ,  ASEl ,  蛋白質 ,  脳・神経 ,  筋萎縮性側索硬化症 ,  機能回復 ,  脳神経疾患 ,  Derlin-l ,  シグナル伝達 ,  ALS ,  神経細胞死 ,  神経変性疾患 ,  ストレス ,  小胞体ストレス ,  細胞死 ,  アポトーシス ,  ASK1 ,  MAPキナーゼ
Research theme for competitive and other funds  (33)：
  • 2022 - 2025 病態脳における小胞体プロテオスタシス破綻によるコレステロール合成不全と脳萎縮
  • 2020 - 2022 Establishment of a method for identification of ubiquitin ligase substrates in eukaryotic cells by application of bacterial ubiquitin-like modifier Pup
  • 2017 - 2022 Analysis of sorting zones involved in protein quality control in the endoplasmic reticulum
  • 2018 - 2021 Elucidation of the role of organelle stress response in oral cancer stem cells
  • 2018 - 2020 小胞体-ミトコンドリア接触場における温度センシング機構の解明
Show all
Papers (69)：
  • Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Hideki Nishitoh. Chemical chaperones ameliorate neurodegenerative disorders in Derlin-1-deficient mice via improvement of cholesterol biosynthesis. Scientific reports. 2022. 12. 1. 21840-21840
  • Takashi Sugiyama, Naoya Murao, Hisae Kadowaki, Keizo Takao, Tsuyoshi Miyakawa, Yosuke Matsushita, Toyomasa Katagiri, Akira Futatsugi, Yohei Shinmyo, Hiroshi Kawasaki, et al. ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function. iScience. 2021. 24. 7. 102758-102758
  • Hironori Kato, Kohki Okabe, Masato Miyake, Kazuki Hattori, Tomohiro Fukaya, Kousuke Tanimoto, Shi Beini, Mariko Mizuguchi, Satoru Torii, Satoko Arakawa, et al. ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue. Life science alliance. 2020. 3. 3
  • Yuki Tatenaka, Hironori Kato, Munetaka Ishiyama, Kazumi Sasamoto, Masanobu Shiga, Hideki Nishitoh, Yuichiro Ueno. Monitoring Lipid Droplet Dynamics in Living Cells by Using Fluorescent Probes. Biochemistry. 2019. 58. 6. 499-503
  • Hisae Kadowaki, Pasjan Satrimafitrah, Yasunari Takami, Hideki Nishitoh. Molecular mechanism of ER stress-induced pre-emptive quality control involving association of the translocon, Derlin-1, and HRD1. Scientific Reports. 2018. 8. 1. 7317
ｍore...
MISC (49)：
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Patents (1)：
Professional career (1)：
  • 博士(歯学) (東京医科歯科大学)
Work history (5)：
  • 2012/03 - 現在 Univ. Miyazaki Prof.
  • 2008/04 - 2012/02 東京大学 大学院薬学研究科 特任研究員
  • 2007/04 - 2008/03 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
  • 2004/01 - 2008/03 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
  • 2000/09 - 2003/12 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences
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