Hagihara Hideo

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://www.fujita-hu.ac.jp/~smedsci/

Research keywords (16)： Neuropsychiatric disorders , Brain endophenotype , Gene expression pattern , Neurogenesis , Neuronal maturation , Metabolism , pH , Lactate , Lactylation , 遺伝子改変マウス , Behavioral test battery , うつ病 , 双極性障害 , 統合失調症 , 歯状回 , 海馬

Research theme for competitive and other funds (6)：

2021 - 2024 Protein lactylation in the brains of animal models of neuropsychiatric disorders
2018 - 2021 脳のpH変化の機能的意義と分子メカニズムの解明
2016 - 2018 Maturation abnormalities of astrocytes in the brain of mouse model of psychiatric disorders
2013 - 2018 Elucidation and regulation of bi-directional changes in neuronal maturation status
2014 - 2016 Time-course analysis of gene expression patterns in the brain of a mouse model of schizophrenia during postnatal development

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Papers (44)：

Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, et al. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. eLife. 2024. 12. RP89376
Yusuke Temma, Kisho Obi-Nagata, Yoshio Hoshiba, Ryuhei Miyake, Yuta Katayama, Hideo Hagihara, Norimitsu Suzuki, Tsuyoshi Miyakawa, Keiichi I. Nakayama, Akiko Hayashi-Takagi. Effect of brain acidification on depression-related behaviors in diabetes mellitus. Frontiers in Psychiatry. 2023. 14. 1277097
Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, et al. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. bioRxiv. 2023. 2021.02.02.428362
Katsutaka Oishi, Yuhei Yajima, Yuta Yoshida, Hideo Hagihara, Tsuyoshi Miyakawa, Sayaka Higo-Yamamoto, Atsushi Toyoda. Metabolic profiles of saliva in male mouse models of chronic sleep disorders induced by psychophysiological stress. Scientific Reports. 2023. 13. 1. 11156
Hideo Hagihara, Tomoyuki Murano, Tsuyoshi Miyakawa. The gene expression patterns as surrogate indices of pH in the brain. Frontiers in Psychiatry. 2023. 14. 1151480

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MISC (51)：

古田島浩子, 古田島浩子, 萩原英雄, 佐藤敦志, 佐藤敦志, 萩野洋子, 田中美歩, 加藤喜久, 加藤喜久, 西藤泰昌, et al. 胎生期におけるGABA_A受容体アンタゴニストのピクロトキシン暴露による仔の自閉症様行動と異常な遺伝子発現. 日本神経化学会大会抄録集(Web). 2022. 65th
中島龍一, 服部聡子, 萩原英雄, 昌子浩孝, 芳本玲, 船坂哲平, FREESIA Huang, 宮川剛. Neurogranin knockout mice display multiple levels of phenotypes associated with schizophrenia. 日本神経精神薬理学会プログラム・抄録集. 2020. 50th
Hideo Hagihara, Tsuyoshi Miyakawa. Systematic analysis of brain pH and lactate levels in animal models: relationships and implications for behavioral outcomes. International Behavioural and Neural Genetics Society. 2019
永井正義, 永井正義, 家村顕自, 服部聡子, 吉川貴子, 萩原英雄, 安澤隼人, 木下賢吾, 大隅典子, 宮川剛, et al. 染色体整列因子CAMP(CHAMP1)欠損による知的障害発症メカニズムの解明. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
Hideo Hagihara. Decreased brain pH in patients with depression and in a social defeat mouse model. The 41st Annual Meeting of the Japan Neuroscience Society, Kobe. 2018

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Patents (1)：

精神病モデル動物の作成方法

Lectures and oral presentations (7)：

神経精神疾患モデル動物の脳における組織pHおよび乳酸濃度の網羅的解析
(文部科学省新学術領域研究学術研究支援基盤形成先端モデル動物支援プラットフォーム若手支援技術講習会 2020)
Decreased brain pH as a shared endophenotype of psychiatric disorders
(6th Congress of Asian College of Neuropsychopharmacology 2019)
脳内中間表現型:遺伝子と行動をつなぐキーコンセプト
(2018年度遺伝研研究会 2018)
Endophenotype in the brain: A key concept for understanding the relationships between genes and behavior
(つくばブレインサイエンスセミナー 2018)
Endophenotype in the brain: A key concept for understanding the relationships be tween genes and behavior
(ConBio2017 2017)

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Professional career (1)：

博士(医学) (藤田保健衛生大学)

Work history (6)：

2024/04 - 現在 Associate Professor, Division of Systems Medical Science, Center for Medical Science, Fujita Health University
2022/04 - 現在藤田医科大学医療科学部, 兼任講師
2022/04 - 2024/03 藤田医科大学医科学研究センターシステム医科学研究部門, 講師(組織名称変更)
2018/10 - 2022/03 Fujita Health University
2020/04 - 2021/03 藤田医科大学医療科学部兼任准教授

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Committee career (7)：

2023/04 - 現在 Councilor, The Japan Neuroscience Society
2022/09 - 現在 Associate Editor, Frontiers in Behavioral Neuroscience
2022/04 - 現在病態モデル先端医学研究センター運営委員
2022/04 - 現在藤田医科大学医学部広報委員
2021/04 - 現在藤田医科大学アセンブリ教育センターアセンブリII運営委員会委員

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Awards (7)：

2022/10 - NPPR Article Award 2022 (Neuropsychopharmacology Reports)
2022/10 - NPPR Topic Award 2022 (Neuropsychopharmacology Reports)
2017/04 - JSNP Excellent Presentation Award for AsCNP 2017 Bali (Japanese Society of Neuropsychopharmacology)
2016/10 - The Fujita Medical Society Young Investigator Award
2016/07 - JSNP Excellent Presentation Award for CINP 2016 Seoul (Japanese Society of Neuropsychopharmacology)

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Association Membership(s) (4)：

THE JAPANESE SOCIETY OF NEUROPSYCHOPHARMACOLOGY , Society for Neuroscience , THE JAPAN NEUROSCIENCE SOCIETY , The Asian College of Neuropsychopharmacology

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