Takahashi Nobuyuki

タカハシノブユキ | Takahashi Nobuyuki

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： http://db.tohoku.ac.jp/whois/detail/6cde0fd560a25c461b11a2fb7e1678c5.html , http://db.tohoku.ac.jp/whois/e_detail/6cde0fd560a25c461b11a2fb7e1678c5.html

Research field (8)： Physiology , Clinical pharmacy , Pharmacology , Developmental biology , Metabolism and endocrinology , Laboratory animal science , Nephrology , Obstetrics and gynecology

Research keywords (5)： hypertension , metabolic syndrome , kidney disease , diabetic nephropathy , preeclampsia, hypertensive disease of pregnancy

Research theme for competitive and other funds (11)：

2021 - 2024 ニコチンアミドによる慢性腎臓病の治療・予防と新規治療薬の開発
2019 - 2022 Elucidating the pathogenic mechanism of CKD-associated cognitive dysfunction and muscle wasting as revealed by metabolic changes in organs
2018 - 2021 Development of a new model mouse for preeclampsia and establishment of placental / fetal blood vessel development evaluation method.
2017 - 2020 Studies of therapeutic medicines for pregnancy complicated with renal disease
2016 - 2019 Uremic sarcopenia induced by uremic toxins in chronic kidney disease

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Papers (144)：

Yuji Oe, Nobuyuki Takahashi. Tissue Factor, Thrombosis, and Chronic Kidney Disease. Biomedicines. 2022. 10. 11
岩本千奈, 堰本晃代, 高橋信行, 佐藤恵美子. ラクトフェリン投与による慢性腎臓病およびその合併症の進行抑制効果. 日本腎臓学会誌. 2022. 64. 3. 221-221
Sota Todoriki, Yui Hosoda, Tae Yamamoto, Mayu Watanabe, Akiyo Sekimoto, Hiroshi Sato, Takefumi Mori, Mariko Miyazaki, Nobuyuki Takahashi, Emiko Sato. Methylglyoxal Induces Inflammation, Metabolic Modulation and Oxidative Stress in Myoblast Cells. Toxins. 2022. 14. 4
Shu Yamakage, Yuji Oe, Emiko Sato, Koji Okamoto, Akiyo Sekimoto, Satoshi Kumakura, Hiroshi Sato, Mai Yoshida, Tasuku Nagasawa, Mariko Miyazaki, et al. Myeloid cell-derived coagulation tissue factor is associated with renal tubular damage in mice fed an adenine diet. Scientific Reports. 2021. 11. 1. 12159-12159
山陰周, 大江佑治, 佐藤恵美子, 堰本晃代, 宮崎真理子, 佐藤博, 伊藤貞嘉, 高橋信行. 凝固活性と関連する尿毒素の網羅的検討. 日本腎臓学会誌. 2021. 63. 4. 458-458

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MISC (82)：

岩本千奈, 堰本晃代, 高橋信行, 佐藤恵美子. ラクトフェリン投与による慢性腎臓病およびその合併症の進行抑制効果. 日本腎臓学会誌(Web). 2022. 64. 3
大江佑治, 佐藤恵美子, 佐藤博, 宮崎真理子, 伊藤貞嘉, 高橋信行. ウレミックトキシンが凝固線溶系因子発現に及ぼす影響. 日本腎臓学会誌(Web). 2021. 63. 4
Emiko Sato, Koji Hosomi, Akiyo Sekimoto, Eikan Mishima, Yuji Oe, Daisuke Saigusa, Sadayoshi Ito, Takaaki Abe, Hiroshi Sato, Jun Kunisawa, et al. Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition. Biochemical and biophysical research communications. 2020. 525. 3. 773-779
熊倉慧, 佐藤恵美子, 堰本晃代, 大江佑治, 宮崎真理子, 高橋信行. ニコチンアミドは炎症の抑制によりアデニン腎症発生を予防する. 日本腎臓学会誌(Web). 2020. 62. 4
山陰周, 大江佑治, 佐藤恵美子, 堰本晃代, 岡本好司, 宮崎真理子, 佐藤博, 伊藤貞嘉, 高橋信行. 単球・マクロファージ由来組織因子の慢性腎臓病における役割. 日本腎臓学会誌(Web). 2020. 62. 4

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Patents (2)：

妊娠高血圧症モデル動物
ニコチンアミドによる妊娠高血圧症候群、流産・早産、及び胎児発育不全の改善

Education (3)：

1996 - 1997 university of North Carolina at Chapel Hill School of Medicine Department of Pathology and Laboratory Medicine
1990 - 1995 Tohoku University Graduate School of Medicine
1983 - 1989 Tohoku University Faculty of Medicine

Professional career (1)：

医学博士 (Tohoku University)

Work history (5)：

2019/10 - 現在 Tohoku University Graduate School of Medicine
2019/10 - 現在 Tohoku University Graduate School of Pharmaceutical Sciences Division of Clinical Pharmacy and Therapeutics Professor
1997/10 - 現在 University of North Carolina at Chapel Hill
2010/08 - 2019/09 Tohoku University Graduate School of Medicine
2010/08 - 2019/09 Tohoku University Graduate School of Pharmaceutical Sciences

Committee career (2)：

2018 - 現在日本妊娠高血圧学会評議員
- 現在日本高血圧学会評議員

Awards (7)：

2020 - American Physiological Society Award of Excellence in Renal Physiology Dual blockade of protease-activated receptor 1 and 2 additively ameliorates diabetic kidney disease. Am J Physiol 2020 May 1;318(5):F1067-F1073
2017 - 東北大学薬学研究科東北大学薬学研究科科長賞(研究面)
2017 - 東北大学医学部東北大学医学部奨学賞金賞妊娠高血圧腎症の新規薬物治療の開発
2008 - Gordon Research Conference Poster Award of Angiotensin
1996 - 東北大学医学部東北大学医学部奨学賞銀賞ヘンレの細い上行脚のNaCl輸送とその調節

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