Rchr
J-GLOBAL ID:201101042871086150   Update date: Apr. 23, 2024

kazuhide asakawa

アサカワ カズヒデ | kazuhide asakawa
Affiliation and department:
Job title: Associate professor
Homepage URL  (2): https://www.asakawalab.com/https://www.asakawalab.com/en
Research field  (3): Developmental biology ,  Cell biology ,  Neuroscience - general
Research keywords  (17): Phase transition ,  optogenetics ,  RNA metabolism ,  TDP-43 ,  ALS ,  motoneuron ,  reticulospinal neuron ,  ALS ,  brainstem ,  locomotion ,  escape behavior ,  ethology ,  microtubule ,  spinal cord ,  embryogenesis ,  zebrafish ,  包括脳ネットワーク
Research theme for competitive and other funds  (28):
  • 2022 - 2026 Optogenetic interrogation of TDP-43 cytotoxicity
  • 2023 - 2025 光遺伝学を用いた低複雑性ドメイン蛋白質の生体内凝集機構の解明
  • 2023 - 2025 DNA損傷応答能の低下がもたらす神経細胞のALS脆弱性
  • 2021 - 2025 TDP-43の病理的相転移に起因する細胞毒性の理解と制御
  • 2022 - 2024 DNA損傷応答の低下がもたらす神経細胞のALS脆弱性
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Papers (55):
  • Yuki Otsuka, Keiko Imamura, Akio Oishi, Kazuhide Asakawa, Takayuki Kondo, Risako Nakai, Mika Suga, Ikuyo Inoue, Yukako Sagara, Kayoko Tsukita, et al. Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction. JCI insight. 2024. 9. 8
  • Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakami. In Vivo Optogenetic Phase Transition of an Intrinsically Disordered Protein. Methods in molecular biology (Clifton, N.J.). 2024. 2707. 257-264
  • Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakami. Dysregulated TDP-43 proteostasis perturbs excitability of spinal motor neurons during brainstem-mediated fictive locomotion in zebrafish. Development, Growth & Differentiation. 2023
  • Kazuhide Asakawa, Hiroshi Handa, Koichi Kawakami. Optogenetic interrogation of TDP-43 cytotoxicity in a zebrafish ALS model. Folia Pharmacologica Japonica. 2023. 158. 1. 16-20
  • 浅川和秀. 神経疾患のモデル動物としてのゼブラフィッシュ. 生体の科学. 2022. 73. 6. 585-590
more...
Books (7):
  • Brain Science Review
    2023 ISBN:9784910513140
  • フロントランナー直伝 : 相分離解析プロトコール : 今すぐ実験したくなる、論文にはないコツや技
    羊土社 2022 ISBN:9784758122597
  • ゼブラフィッシュ実験ガイド
    朝倉書店 2020 ISBN:9784254171730
  • Gene trapping
    Brenner's Encyclopedia of Genetics, 2nd edn 2012
  • メダカトランスポゾンTol2が開く新しいゼブラフィッシュ研究
    細胞工学 2009
more...
Lectures and oral presentations  (132):
  • Reorganization of central carbon metabolism rescues TDP-43 proteostasis collapse in spinal motor neurons
    (The 34th International Symposium on ALS/MND 2023)
  • Reorganization of central carbon metabolism rescues TDP-43 proteostasis collapse in spinal motor neurons
    (2023)
  • Exploring the Intersection of Neuronal Vulnerability and Ploidy in ALS.
    (The 1st Ploidy Meeting 2023)
  • 光遺伝学を用いたTDP-43の相転移操作で探るALS病態
    (千里ライフサイエンス振興財団セミナー「相分離がもたらす医療・創薬の新展開」 2023)
  • An inverse relationship between autophagic flux and intracellular ATP level in ALS-vulnerable neuronal types in zebrafish
    (2022)
more...
Education (2):
  • 1997 - 2002 The University of Tokyo Graduate School of Science Department of Biological Sciences
  • 1993 - 1997 Kyoto University Faculty of Science Biology
Professional career (1):
  • 博士(理学) (東京大学)
Work history (7):
  • 2024/04 - 現在 National Institute of Genetics Associate Professor
  • 2022 - 現在 National Institute of Genetics
  • 2019 - 2022 Tokyo Medical University Associate professor
  • 2009 - 2019 National Institute of Genetics Assistant professor
  • 2006 - 2009 National Institute of Genetics JSPS Research Fellow (PD)
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Committee career (5):
  • 2021/07 - 2022/06 日本学術振興会 特別研究員等審査会専門委員、卓越研究員候補者選考委員会書面審査員、国際事業委員会書面審査員・書面評価員
  • 2021/06 - Zebrafish Disease Model Society Board of Directors
  • 2016 - 2016 日本遺伝学会 年会プログラム委員
  • 2015 - 2015 日本糖質学会 年会プログラム委員
  • 2014 - 2014 日本発生生物学会 年会プログラム委員
Awards (4):
  • 2020/12 - SERIKA FUND SERIKA FUND AWARD
  • 2017/12 - SERIKA FUND SERIKA FUND
  • 2014/03 - 公益信託「生命の彩」ALS研究助成基金 [生命の彩」ALS研究助成 研究表彰
  • 2007 - Best Poster at 5th European Zebrafish Genetics and Development Meeting
Association Membership(s) (5):
Japanese Society for Developmental Biology ,  The Molecular Biology of Japan ,  THE JAPAN NEUROSCIENCE SOCIETY ,  International Zebrafish Society ,  Zebrafish Disease Model Society
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