Rchr

J-GLOBAL ID：201101050539417057 Update date: Jun. 22, 2024

Katsuno Masahisa

カツノマサヒサ | Katsuno Masahisa

Affiliation and department：
Other affiliations (2)：

Nagoya University Graduate School of Medicine Department of Clinical Research Education Professor
iGCORE Professor

Research field (1)： Neurology

Research keywords (5)： clinical trial , translational research , spinal and bulbar muscular atrrophy , polyglutamine disease , neurodegenerative disease

Research theme for competitive and other funds (51)：

2023 - 2026 Elucidation of temporal alteration in motor neuron-oligodendrocyte interaction in motor neuron diseases
2023 - 2026 Investigation of mechanistic links between tauopathies and TDP-43 proteinopathies
2023 - 2026 球脊髄性筋萎縮症における超早期バイオマーカーの開発
2022 - 2025 Development of neuronal aggregates-targeted therapeutics
2022 - 2025 Study of synaptic pahtology caused by FUS in amyotrophic lateral sclerosis

2022 - 2024 遠位型遺伝性運動ニューロパチー7型の病態解明と病態抑止療法の開発

2022 - 2024 運動ニューロン疾患の初期軸索病態の解明

2021 - 2024 球脊髄性筋萎縮症レジストリデータを用いた病態進行に関わる因子の同定

2021 - 2023 Wide-field Ca imaging and trans-omics for mouse model of Lewy body disease

2020 - 2023 非全身性血管炎性ニューロパチーの病態解明と新規治療法の開発

2020 - 2023 超早期ライフステージに着目した神経変性疾患の時空間特異性の解明

2020 - 2023 免疫介在性ニューロパチーの疾患活動性を反映する新規バイオマーカーの開発

2020 - 2023 孤発性ALSにおける凝集型TDP-43の生体内伝播メカニズムの解明

2019 - 2023 異常タンパク分解系を標的とした運動ニューロン疾患治療薬の開発

2019 - 2022 Elucidation of the progression of multiple system atrophy by head MRI

2019 - 2022 Understanding of defective developmental gene regulation responsible for motor neuron degeneration

2019 - 2022 候補遺伝子アプローチによる筋萎縮性側索硬化症病態関連遺伝子の探索

2018 - 2021 Long-term effect of leuprorelin acetate on the patients with spinal and bulbar muscular atrophy

2018 - 2021 球脊髄性筋萎縮症の適正治療に関するエビデンス構築のための臨床研究

2018 - 2020 Understanding of intrinsic readthrough mechanisms of nonsense mutations for its therapeutic applications

2018 - 2020 球脊髄性筋萎縮症に対する骨格筋トランスポーターを標的とした治療法開発

2017 - 2020 Elucidation of defective neural communication in motor neuron diseases

2017 - 2020 Therapeutic development based on factors affecting progression and prognosis of amyotrophic lateral sclerosis

2017 - 2020 Discovery of novel target and disease modifying therapy for ALS/FTLD using neuro-specific transcriptome analysis

2017 - 2020 Deciphering the mechanism of neuropathy and development of novel therapies in familial amyloid polyneuropathy

2017 - 2020 運動ニューロン疾患における神経・筋システム変性の分子病態解明と治療法開発

2017 - 2020 球脊髄性筋萎縮症の神経筋システム変性を標的とした革新的治療法開発

2017 - 2019 Analysis of genes affecting cognitive function in sporadic ALS

2016 - 2019 Elucidation of the axonal degenerative mechanism focusing on the paranodal molecules in immune-mediated neuropathy

2016 - 2019 Development of biomarkers of sleep disturbance in Parkinson's disease using salivary melatonin

2015 - 2018 Biomarker study in the early phase patients with spinal and bulbar muscular atrophy

2016 - 2017 Elucidation of dysregulation of exocytosis in sporadic amyotrophic lateral sclerosis

2016 - 2017 多系統萎縮症の正確な病期診断法の開発

2014 - 2017 Elucidation of pathogenesis of sporadic ALS using motor neuron specific-dynactin-1 knockout mice

2014 - 2017 Dissection of the pathomechanisms of motor neuron disease using antisense therapeutics

2014 - 2017 運動ニューロン疾患における神経・筋システム変性の分子病態解明と治療法開発

2015 - 2016 Development of biomarker and therapy for amyotrophic lateral sclerosis targeting cystatin C

2014 - 2016 A drug screening system for ALS by automated, quantitative motility analysis of C. elegans ALS model

2013 - 2015 統合的脳MRIネットワーク解析によるALSの運動機能-前頭葉機能間関連性の解明

2014 - 2015 球脊髄性筋萎縮症におけるクレアチニン代謝異常の病態解明と探索的臨床試験

2010 - 2015 運動ニューロン疾患におけるニューロサーキット変性の病態解明と治療法開発

2013 - 2014 Therapeutic strategy of neurodegenerative disease using microRNA

2011 - 2014 Development of therapy targeting dysregulation of cell cycle and JNK pathway in polyglutamine diseases

2009 - 2014 Development of Molecular Targeted Disease Modifying Therapy for Polyglutamine Diseases

2012 - 2014 球脊髄性筋萎縮症における活動依存性シナプス病態の解明と治療法の開発

2010 - 2012 Elucidation of pathogenesis and therapy development of sporadic ALS by disease model

2009 - 2010 Elucidation of cellular signaling defect and mechanism of cell-specific degeneration in polyglutamine diseases

2008 - 2010 Therapeutic strategy for polyglutamine-mediated motor neuron disease via molecular chaperone-ubiquitin proteasome system

2005 - 2009 Development of pathogenesis-based therapy for polyglutamine diseases

2007 - 2008 Development of animal model for sporadic ALS

2007 - 2008 Pathogenesis-based therapy development for polyglutamine diseases

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Papers (1,032)：

Naoki Suzuki, Madoka Mori-Yoshimura, Masahisa Katsuno, Masanori P Takahashi, Satoshi Yamashita, Yasushi Oya, Atsushi Hashizume, Shinichiro Yamada, Masayuki Nakamori, Rumiko Izumi, et al. Safety and efficacy of aceneuramic acid in GNE myopathy: open-label extension study. Journal of neurology, neurosurgery, and psychiatry. 2024
Hiroshi Nishiwaki, Jun Ueyama, Mikako Ito, Tomonari Hamaguchi, Keiichi Takimoto, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Hiroshi Mori, Ken Kurokawa, et al. Meta-analysis of shotgun sequencing of gut microbiota in Parkinson's disease. NPJ Parkinson's disease. 2024. 10. 1. 106-106
Yuki Fukami, Masahiro Iijima, Haruki H Koike, Satoru Yagi, Soma Furukawa, Naohiro Mouri, Jun Ouchida, Ayuka Murakami, Madoka Iida, Satoshi Yokoi, et al. Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies. Neurology(R) neuroimmunology & neuroinflammation. 2024. 11. 2. e200199
Satoshi Yamashita, Yuji Takahashi, Jun Hashimoto, Ayuka Murakami, Ryoichi Nakamura, Masahisa Katsuno, Rumiko Izumi, Naoki Suzuki, Hitoshi Warita, Masashi Aoki. Nationwide survey of patients with multisystem proteinopathy in Japan. Annals of Clinical and Translational Neurology. 2024
Yusuke Fujioka, Kaori Kawai, Kuniyuki Endo, Minaka Ishibashi, Nobuyuki Iwade, Dilina Tuerde, Kozo Kaibuchi, Takayuki Yamashita, Akihiro Yamanaka, Masahisa Katsuno, et al. Stress-impaired reward pathway promotes distinct feeding behavior patterns. Frontiers in neuroscience. 2024. 18. 1349366-1349366

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MISC (405)：

小野寺一成, 小野寺一成, 下門大祐, 石原康晴, 太田明伸, IRFANUR Rashid Muhammad, 伊藤卓治, 岡田梨奈, 細川好孝, 道勇学, et al. 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症(SBMA)の早期病態解明と治療開発. 日本再生医療学会総会(Web). 2023. 22nd
伊藤卓治, ラシッドムハンマドイルファヌール, 小野寺一成, 小野寺一成, 岡田梨奈, 下門大祐, 下門大祐, 田中智史, 田中智史, 勝野雅央, et al. 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の神経・筋病態の解明. 日本再生医療学会総会(Web). 2023. 22nd
岸本祥之, 橋詰淳, 山田晋一郎, 伊藤大輔, 小森祥太, 阿部友和, 戸田莉恵, 安永好宏, 勝野雅央, 勝野雅央. 脊髄小脳変性症患者に対する遠隔モニタリングを利用した在宅運動療法. 日本神経学会学術大会プログラム・抄録集. 2023. 64th
前田憲多郎, 辻河高陽, 平野聡子, 野田成哉, 勝野雅央. 呼吸障害の改善を得た骨格筋線維内に脂質蓄積を伴う成人発症ミオパチーの1例の治療経験. 神経治療学. 2022. 39. 6. S289-S289
辻河高陽, 濱中耕平, 陸雄一, 陸雄一, 服部祐季, 井口洋平, 小林憲太, 池内健, 宮田卓樹, 松本直通, et al. アクチン結合蛋白フィラミンAはタウ凝集を促進し,進行性核上性麻痺の病理に関連する. 日本神経化学会大会抄録集(Web). 2022. 65th

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Professional career (1)：

Doctor of Medicine (Nagoya University)

Work history (11)：

2021/04 - 現在 Nagoya University Graduate School of Medicine Department of Clinical Research Education Professor
2021/04 - 現在 iGCORE Professor
2015/07/01 - 現在 Nagoya University Graduate School of Medicine Program in Integrated Medicine Clinical Neurosciences Professor
2012/12/01 - 2015/06/30 Nagoya University Graduate School of Medicine Program in Integrated Medicine Clinical Neurosciences Associate professor
2011/04/01 - 2012/11/30 Nagoya University Graduate School of Medicine Center for Research of Laboratory Animals and Medical Research Engineering Division Designated associate professor

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Awards (3)：

2020/04/07 - MEXT, Japan Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology
2014/05 - 日本神経学会日本神経学会賞
2009/03/09 - 日本学術振興会日本学術振興会賞

Association Membership(s) (10)：

日本認知症学会 , 日本神経科学会 , 日本末梢神経学会 , 日本自律神経学会 , 日本健診医学会 , Society for Neuroscience , 日本内科学会 , 日本神経学会 , 日本臨床薬理学会 , 日本神経治療学会

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