Kobori Hiroyuki

コボリヒロユキ | Kobori Hiroyuki

Affiliation and department：
Job title：教授

Research field (4)： Nephrology , Pharmacology , Clinical pharmacy , Physiology

Research keywords (8)：腎疾患 , 高血圧 , レニンーアンジオテンシン系 , アンジオテンシノーゲン , kidney disease , hypertension , renin-angiotensin system , angiotensinogen

Research theme for competitive and other funds (25)：

2015 - 2019 高血圧患者における新規バイオマーカーとしての尿中アンジオテンシノーゲンの臨床応用
2014 - 2015 Effect of DRI on Urinary Angiotensinogen (a Novel Biomarker of Intrarenal Renin-Angiotensin-Aldosterone System) in the presence of CCB in Diabetic Mice
2012 - 2014 Potential of Urinary AGT as a Novel Biomarker for Intrarenal RAS Activity in T1DM
2013 - 2014 糖尿病性腎症患者を対象としたDPP-4阻害剤の腎保護効果に関する臨床調査研究
2012 - 2014 高血圧患者において、尿中AGTは、腎臓内RASを反映し、CKD患者の管理に有益な、新規バイオマーカーとなる

2012 - 2013 高血圧患者における新規バイオマーカーとしての尿中アンジオテンシノーゲンの臨床応用

2011 - 2013 Renoprotective Effects of Aliskiren on Chronic Glomerulonephritis

2011 - 2012 Renoprotective Effects of Combination Therapy of Olmesartan and Azelnidipine with Special Reference on Urinary Angiotensinogen as a Novel Biomarker of Diabetic Nephropathy

2010 - 2012 Rho-kinase Pathway in Angiotensin II-dependent Hypertension

2007 - 2012 Research Enhancement Fund

2011 - 2012 高血圧患者において、尿中AGTは、腎臓内RASを反映する新規バイオマーカーとなる

2006 - 2012 Intrarenal Augmentation of Angiotensinogen by Ang II

2002 - 2011 Tulane COBRE in Hypertension and Renal Biology

1998 - 2011 Renal Functional Derangements in Hypertension

2009 - 2011 Renal Protection of SPP100 in Human Renin and Angiotensinogen Transgenic Mice in Blood Pressure-Independent Manner

2009 - 2011 Intrarenal Augmentation of Angiotensinogen by Ang II

2008 - 2009 Activated Intrarenal ROS-AGT Axis in IgA Nephropathy and Renal Protective Effects of Olmesartan

2008 - 2009 Urinary Angiotensinogen as a Novel Biomarker of Intrarenal RAS Activity in Hypertensive Patients

2008 - 2008 Urinary AGT as a Novel Biomarker of Intrarenal RAS Activity

2005 - 2008 Renoprotective Effect of Chymase Inhibitors in Angiotensin

2005 - 2007 MAP Kinase-Dependent Intrarenal Angiotensinogen Enhancement in Diabetes and Renal Protective Effect of Olmesartan

2002 - 2005 Tissue Angiotensin in the Kidney and Renal Protective Effect of Olmesartan

2001 - 2003 Intrarenal Regulation of Angiotensinogen Expression by Angiotensin II in Gene Targeted Mice

1997 - 1999 甲状腺機能亢進症による心肥大における組織レニン・アンジオテンシン系の関与

1996 - 1997 心肥大における組織レニン・アンジオテンシン系の関与

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Papers (172)：

Tsuneo Takenaka, Hiroyuki Kobori, Takashi Miyazaki, Hiromichi Suzuki, Akira Nishiyama, Naohito Ishii, Maho Yamashita, Matsuhiko Hayashi. Klotho protein supplementation reduces blood pressure and renal hypertrophy in db/db mice, a model of type 2 diabetes. Acta physiologica (Oxford, England). 2019. 225. 2. e13190
Akira Nishiyama, Hiroyuki Kobori. Independent regulation of renin-angiotensin-aldosterone system in the kidney. Clinical and experimental nephrology. 2018. 22. 6. 1231-1239
Arif U Hasan, Koji Ohmori, Takeshi Hashimoto, Kazuyo Kamitori, Fuminori Yamaguchi, Asadur Rahman, Masaaki Tokuda, Hiroyuki Kobori. PPARγ activation mitigates glucocorticoid receptor-induced excessive lipolysis in adipocytes via homeostatic crosstalk. Journal of cellular biochemistry. 2018. 119. 6. 4627-4635
Lei Li, Yoshio Konishi, Takashi Morikawa, Yifan Zhang, Chizuko Kitabayashi, Hideki Kobara, Tsutomu Masaki, Daisuke Nakano, Hirofumi Hitomi, Hiroyuki Kobori, et al. Effect of a SGLT2 inhibitor on the systemic and intrarenal renin-angiotensin system in subtotally nephrectomized rats. Journal of pharmacological sciences. 2018. 137. 2. 220-223
Asadur Rahman, Arif Ul Hasan, Akira Nishiyama, Hiroyuki Kobori. Altered Circadian Timing System-Mediated Non-Dipping Pattern of Blood Pressure and Associated Cardiovascular Disorders in Metabolic and Kidney Diseases. International journal of molecular sciences. 2018. 19. 2

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Patents (1)：

METHOD FOR EVALUATING RENIN ACTIVITY, METHOD FOR TESTING MORBIDITY POTENTIAL FOR PRIMARY ALDOSTERONISM, AND KIT USING SAME

Education (1)：

1984 - 1990 Keio University School of Medicine Depertment of Medicine

Professional career (1)：

博士(医学) (慶應義塾大学)

Work history (1)：

International University of Health and Welfare School of Medicine Department of Medicine

Awards (11)：

2010 - チュレーン大学 Inaugural Oliver Fund Scholar Award
2008 - American Heart Association Harry Goldblatt New Investigator Award Finalist
2005 - American Heart Association Kidney Council New Investigator Travel Award
2005 - American Society of Hypertension Young Scholars Award
2002 - American Heart Association New Investigator Travel Award

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