Yasuyuki Nagumo

Affiliation and department：

Research field (1)： Neuroscience - general

Research keywords (1)：包括脳ネットワーク

Research theme for competitive and other funds (2)：

2015 - 2017 末梢神経損傷による視床シナプス外部GABA電流の変化と視床神経回路改編への影響
2012 - 2015 神経損傷後の視床神経回路改編と視床細胞活動の関係性-ウイルスベクターによる解析-

Papers (34)：

Yasuyuki Nagumo, Koki Katoh, Keita Iio, Tsuyoshi Saitoh, Noriki Kutsumura, Naoshi Yamamoto, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Takeshi Baba, et al. Discovery of attenuation effect of orexin 1 receptor to aversion of nalfurafine: Synthesis and evaluation of D-nor-nalfurafine derivatives and analyses of the three active conformations of nalfurafine (in press). 2020
Yasuyuki Nagumo, Yoshifumi Ueta, Hisako Nakayama, Hironobu Osaki, Yuichi Takeuchi, Naofumi Uesaka, Masanobu Kano, Mariko Miyata. Tonic GABAergic Inhibition Is Essential for Nerve Injury-Induced Afferent Remodeling in the Somatosensory Thalamus and Ectopic Sensations. Cell Reports. 2020. 31. 12. 107797-107797
Noriki Kutsumura, Yasuaki Koyama, Tsuyoshi Saitoh, Naoshi Yamamoto, Yasuyuki Nagumo, Yoshiyuki Miyata, Rei Hokari, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, et al. Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities. Molecules. 2020
Tsuyoshi Saitoh, Kazunori Seki, Ryo Nakajima, Naoshi Yamamoto, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Masashi Yanagisawa, et al. Essential structure of orexin 1 receptor antagonist YNT-707, part V: Structure-activity relationship study of the substituents on the 17-amino group. Bioorganic & medicinal chemistry letters. 2020. 30. 3. 126893-126893
Saitoh, Tsuyoshi, Seki, Kazunori, Nakajima, Ryo, Yamamoto, Naoshi, Kutsumura, Noriki, Nagumo, Yasuyuki, Irukayama-Tomobe, Yoko, Ogawa, Yasuhiro, Ishikawa, Yukiko, Tanimura, Ryuji, et al. Essential structure of orexin 1 receptor antagonist YNT-707, Part IV: The role of D-ring in 4,5-epoxymorphinan on the orexin 1 receptor antagonistic activity. Bioorganic & medicinal chemistry letters. 2019. 29. 18. 2655-2658

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MISC (27)：

南雲康行, 谷田誠浩, 山本直司, 長瀬博. 【日本におけるオピオイド鎮痛薬の臨床と基礎研究の展望】オピオイド鎮痛薬関連研究の新たな展開オピオイド受容体に関する研究新規オピオイド受容体作動薬の開発副作用の分離を目指した新規選択的κ受容体作動薬の設計と合成. ペインクリニック. 2017. 38. 別冊春. S211-S218
南雲康行. 分子から迫る神経薬理学オピオイド受容体 δ受容体. Clinical Neuroscience. 2016. 34. 11. 1188-1189
南雲康行. 分子から迫る神経薬理学オピオイド受容体 κ受容体. Clinical Neuroscience. 2016. 34. 10. 1074-1075
南雲康行. 分子から迫る神経薬理学オピオイド受容体 μ受容体. Clinical Neuroscience. 2016. 34. 9. 954-955
南雲康行. 分子から迫る神経薬理学オピオイド受容体総論. Clinical Neuroscience. 2016. 34. 8. 854-855

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Patents (1)：

<産業財産権・特許>特願 2016-155477,モルヒナン誘導体及びその医薬用途

Books (1)：

トワイクロス先生のがん緩和ケア処方薬 : 薬効・薬理と薬の使い方
医学書院 2013 ISBN:9784260015219

Professional career (1)：

薬学博士 (星薬科大学)

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