Sakai Seiichiro

サカイセイイチロウ | Sakai Seiichiro

Affiliation and department：
Job title： Assistant Professor

Research field (1)： Neuroscience - general

Research keywords (24)：脳卒中 , 脳梗塞 , 大脳皮質 , 神経回路 , 体性感覚 , カルシウムイメージング , Wide-field imaging , 二光子顕微鏡 , GCaMP , FACS , 次世代シークエンス , RNA-seq , シングルセルRNA-Seq , ATAC-Seq , DREADD , 電気生理 , パッチクランプ , オプトジェネティクス , チャネルロドプシン , 視覚 , 海馬 , 樹状突起 , シナプス , 神経科学

Research theme for competitive and other funds (7)：

2024 - 2024 全脳光計測・光操作システムを用いた脳神経回路修復メカニズムの解析
2021 - 2024 脳卒中後の大脳新皮質広域神経回路再構築メカニズムの解明
2021 - 2022 細胞タイプ特異的回路再構築による脳卒中治療法の開発
2018 - 2021 Cell type specific neural circuit structures and circuit formation mechanisms in mouse primary visual cortex
2018 - 大脳新皮質の細胞タイプ特異的な神経回路再構築による脳卒中治療の開発

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Papers (15)：

Akari Nakamura, Seiichiro Sakai, Yoshitaka Taketomi, Jun Tsuyama, Yoshimi Miki, Yuichiro Hara, Nobutaka Arai, Yuki Sugiura, Hideya Kawaji, Makoto Murakami, et al. PLA2G2E-mediated lipid metabolism triggers brain-autonomous neural repair after ischemic stroke. Neuron. 2023. 111. 19. 2995-3010.e9
Seiichiro Sakai, Takashi Shichita. Role of alarmins in poststroke inflammation and neuronal repair. Seminars in immunopathology. 2022
Koutarou Nakamura, Seiichiro Sakai, Jun Tsuyama, Akari Nakamura, Kento Otani, Kumiko Kurabayashi, Yoshiko Yogiashi, Hisao Masai, Takashi Shichita. Extracellular DJ-1 induces sterile inflammation in the ischemic brain. PLoS biology. 2021. 19. 5. e3000939
Seiichiro Sakai, Takashi Shichita. Inflammation and neural repair after ischemic brain injury. Neurochemistry international. 2019. 130. 104316-104316
Yoneda T, Sakai S, Maruoka H, Hosoya T. Large-scale Three-dimensional Imaging of Cellular Organization in the Mouse Neocortex. Journal of visualized experiments : JoVE. 2018. 139

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MISC (25)：

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Lectures and oral presentations (27)：

Top-down Input to the Periinfarct Somatosensory Cortex is Enhanced after Ischemic Stroke
(2023)
Functional connectivity is enhanced in the periinfarct sensorimotor cortex after ischemic stroke
(Neuroscience 2022, SfN's annual meeting 2022)
Reorganization of functional connectivity between cortical areas during functional recovery after ischemic stroke
(The 99th Annual Meeting of The Physiological Society of Japan 2022)
Visualization of Neuronal Circuit Remodeling after Ischemic Stroke by Wide-field Calcium Imaging
(2021)
Remodeling of neuronal connectivity and expression of neurorepair genes in the neocortex after ischemic stroke
(2021)

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Education (2)：

2007 - 2012 東北大学大学院生命科学研究科脳機能解析分野(八尾寛教授)
2003 - 2007 Tohoku University Faculty of Science Department of Biology

Professional career (1)：

博士(生命科学) (東北大学)

Work history (5)：

2023/04 - 現在 Tokyo Medical and Dental University Medical Research Institute Assistant Professor
2017/04 - 2023/03 Tokyo Metropolitan Institute of Medical Science
2013/04 - 2017/03 国立研究開発法人理化学研究所研究員
2012/04 - 2013/03 Japan Society for the Promotion of Science
2011/04 - 2012/03 Japan Society for the Promotion of Science

Awards (1)：

2018/03 - RIKEN Research Incentive Award

Association Membership(s) (3)：

日本生理学会 , 日本神経科学学会 , 北米神経科学会

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