Irie Tomohiko

イリエトモヒコ | Irie Tomohiko

Affiliation and department：

Research field (3)： Clinical pharmacy , Physiology , Neuroscience - general

Research keywords (1)：包括脳ネットワーク

Research theme for competitive and other funds (7)：

2022 - 2025 Elucidation of molecular mechanisms of speech sound onset by integrated molecular, morphological, and electrophysiological approaches
2022 - 2025 Study of sodium leak channel NALCN
2019 - 2022 超解像イメージングと電気生理で解明する、神経でのCa依存性Kチャネル新規調節機構
2016 - 2019 リアノジン受容体による、新規な神経細胞自発発火パターン調節機構の統合的解明
2014 - 2016 KCNQチャネルの小脳での役割を脳スライス電気生理と行動実験で包括的に解明する

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Papers (24)：

Tenzin Ngodup, Tomohiko Irie, Seán P Elkins, Laurence O Trussell. The Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons. eLife. 2024. 12
Kanako Takahashi, Luying Chen, Misa Sayama, Mian Wu, Mariko Kato Hayashi, Tomohiko Irie, Tomohiko Ohwada, Kaoru Sato. Leucine 434 is essential for docosahexaenoic acid-induced augmentation of L-glutamate transporter current. The Journal of biological chemistry. 2022. 102793-102793
Tomohiko Irie, Yuta Yanase, Yosuke Demizu, Makoto Usami, Ruri Kikura-Hanajiri. Derivatives of methoxetamine and major methoxetamine metabolites potently block NMDA receptors. Journal of pharmacological sciences. 2022. 150. 4. 233-243
Azusa Satoh, Shinri Fujimoto, Tomohiko Irie, Takehito Suzuki, Yoko Miyazaki, Kazuaki Tanaka, Makoto Usami, Tatsuya Takizawa. Valproic acid promotes differentiation of adipose tissue-derived stem cells to neuronal cells selectively expressing functional N-type voltage-gated Ca2+ channels. Biochemical and biophysical research communications. 2021. 589. 55-62
Tomohiko Irie. Essential Role of Somatic Kv2 Channels in High-Frequency Firing in Cartwheel Cells of the Dorsal Cochlear Nucleus. eNeuro. 2021. 8. 3

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MISC (8)：

MIYAJIMA Atsuko, KURODA Yukie, SAKEMI-HOSHIKAWA Kazue, SUNOUCHI Momoko, MITSUNAGA Katsuyoshi, IRIE Tomohiko, OHNO Yasuo, USAMI Makoto. Effects of 4- or 5-methyl-2-mercaptobenzimidazole on CYP activity in primary cultured rat hepatocytes. Annual Meeting of the Japanese Society of Toxicology. 2020. 47.1. P-118
Irie Tomohiko. Double-Nanodomain Coupling of P/Q-type Ca²⁺ Channels, Ryanodine Receptors, and BK Channels Controls the Generation of Burst Firing. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2020. 93. 1-S07-1
Takahashi Kanako, Irie Tomohiko, Kanda Yasunari, Sato Kaoru. An attempt to clarify the mechanisms underlying the modulatory effects of Docosahexaenoic acid on human glial glutamate transporter. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2019. 92. 1-P-103
MIYAJIMA Atsuko, SAKEMI-HOSHIKAWA Kazue, USAMI Makoto, MITSUNAGA Katsuyoshi, IRIE Tomohiko, OHNO Yasuo, SUNOUCHI Momoko. In vitro metabolism of 2-mercaptobenzimidazole and its methyl derivatives in rat liver microsomes. Annual Meeting of the Japanese Society of Toxicology. 2019. 46.1. P-121
USAMI Makoto, MITSUNAGA Katsuyoshi, IRIE Tomohiko, MIYAJIMA Atsuko, DOI Osamu, SUNOUCHI Momoko. Valproic acid promotes the migration of cultured rat neural crest cells. Annual Meeting of the Japanese Society of Toxicology. 2017. 44.1. P-201

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Professional career (1)：

Work history (6)：

2023/04 - 現在北里大学医学部生理学(山田単位) 講師
2011/03 - 2023/03 国立医薬品食品衛生研究所薬理部主任研究官
2015/04 - 2017/03 Oregon Health & Science University(OHSU) Oregon Hearing Research Center postdoctoral researcher
2011/04 - 2015/03 Gunma University Faculty of Medicine
2009/04 - 2011/02 Gunma University Graduate School of Medicine

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Association Membership(s) (3)：

Society for Neuroscience , THE JAPAN NEUROSCIENCE SOCIETY , THE PHYSIOLOGICAL SOCIETY OF JAPAN

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