Research theme for competitive and other funds (45):
2020 - 2024 Pathological elucidation of autism by using morphological multi-parameter analysis in neuron and microglia co-culture system
2019 - 2022 成長円錐の膜動態を支えるイノシトールリン脂質制御分子群の統合的機能解析
2019 - 2022 The role of lipid mediator in the tumor immune microenvironment of breast cancer and its therapeutic application
2018 - 2022 Functional analysis of the phosphorylation site of the autism-risk gene neuroligin 3
2018 - 2021 Mechanisms of cancer metabolism and drug resistance regulated by S1P in triple negative breast cancer
2018 - 2021 Groval aanalys of the nerve growth using proteomics and superresolution
2018 - 2020 神経成長における超解像度レベルの脂質ドメイン可視化とその構成脂質特性の解析
2017 - 2020 Function of GAP-43 for axon regeneration after spinal cord injury
2016 - 2020 Glycosilation of glycosaminoglycan in bone marrow affect in hematopoiesis and GVHD after BM transplantation
2015 - 2018 Elucidation of molecular mechanism of lipid mediator involved in metastatic ability of biliary tract cancer / pancreatic cancer and clinical application
2010 - 2016 Comprehensive Brain Science Network
2012 - 2014 リン酸化プロテオミクスに基づくリン酸化神経病態学の確立
2010 - 2014 Functional analysis of the molecular markers of the growth cone
2012 - 2013 Structural asymmetry of the growth cone observed by the novel scanning microscopy
2005 - 2009 A study of searching the growth cone proteins involved in synapse formation
2004 - 2009 Elucidation of neural network function in the brain
Design of drugs maintaining the growth cone function
Design of peptides to overcome inhibition of nerve growth and regeneration
Signal transduction mechanisms in nerve growth cones
Show all
Papers (62):
Motohiro Nozumi, Yuta Sato, Miyako Nishiyama-Usuda, Michihiro Igarashi. Identification of z-axis filopodia in growth cones using super-resolution microscopy. Journal of Neurochemistry. 2024
Di Ja Lasham, Reza K Arta, Abdul Fuad Hadi, Jun Egawa, Vance P Lemmon, Toshiyuki Takasugi, Michihiro Igarashi, Toshiyuki Someya. Effects of MAP4K inhibition on neurite outgrowth. Molecular brain. 2023. 16. 1. 79-79
Atsuko Honda, Motohiro Nozumi, Yasuyuki Ito, Rie Natsume, Asami Kawasaki, Fubito Nakatsu, Manabu Abe, Haruki Uchino, Natsuki Matsushita, Kazutaka Ikeda, et al. Very-long-chain fatty acids are crucial to neuronal polarity by providing sphingolipids to lipid rafts. Cell reports. 2023. 113195-113195
Suguru Tamura, Hajime Ishiguro, Tatsuya Suwabe, Takayuki Katagiri, Kaori Cho, Kyoko Fuse, Yasuhiko Shibasaki, Tadahisa Mikami, Takero Shindo, Hiroshi Kitagawa, et al. Genetic manipulation resulting in decreased donor chondroitin sulfate synthesis mitigates hepatic GVHD via suppression of T cell activity. Scientific reports. 2023. 13. 1. 13098-13098
M. Kishi, T. Nagaoka, S. Uemura, A. Inutsuka, M. Abe, A. Watanabe, Y. Huang, M. Yokoyama, K. Sakimura, M. Igarashi. Branching Kinase (BrancK) regulates arborization of neurites. MOLECULAR BIOLOGY OF THE CELL. 2012. 23