Johmura Yoshikazu

ジョウムラヨシカズ | Johmura Yoshikazu

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Homepage URL (1)： https://www.kazusa.or.jp/aging/

Research field (5)： Cell biology , Molecular biology , Medical biochemistry , Pathobiochemistry , Tumor biology

Research keywords (1)： Aging, Longevity, Cancer, Cellular senescence, Cell cycle, Proteostasis

Research theme for competitive and other funds (12)：

2023 - 2027 細胞種特異的な老化細胞制御システムを用いた個体老化・加齢性疾患病態機構の解明
2023 - 2026 Elucidation of the Aging Clock Revival Mechanism - A New Paradigm Shift in Aging Research
2023 - 2026 老化時計リバイバル機構の解明 -老化研究における新たなパラダイムシフトの総括
2023 - 2026 慢性炎症の起点となる細胞老化のリバイバル機構の解明
2021 - 2025 Study of development of interventions for aged-related diseases and longevity based on understanding of proteostasis during aging

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Papers (49)：

Satoru Meguro, Yoshikazu Johmura, Teh-Wei Wang, Satoshi Kawakami, Shota Tanimoto, Satotaka Omori, Yuki T Okamura, Seiji Hoshi, Emina Kayama, Kiyoshi Yamaguchi, et al. Preexisting senescent fibroblasts in the aged bladder create a tumor-permissive niche through CXCL12 secretion. Nature aging. 2024
Xinyi Zeng, Teh-Wei Wang, Kiyoshi Yamaguchi, Seira Hatakeyama, Satoshi Yamazaki, Eigo Shimizu, Seiya Imoto, Yoichi Furukawa, Yoshikazu Johmura, Makoto Nakanishi. M2 macrophage-derived TGF-β induces age-associated loss of adipogenesis through progenitor cell senescence. Molecular Metabolism. 2024. 84. 101943-101943
Satoshi Kawakami, Yoshikazu Johmura, Makoto Nakanishi. Intracellular acidification and glycolysis modulate inflammatory pathway in senescent cells. The Journal of Biochemistry. 2024
Tomohisa Baba, Utano Tomaru, Atsushi Hirao, Naofumi Mukaida, Yoshikazu Johmura. Autophagy inhibition-induced cytosolic DNA sensing combined with differentiation therapy induces irreversible myeloid differentiation in leukemia cells. Cancer research communications. 2024
Kojiro Suda, Yohsuke Moriyama, Nurhanani Razali, Yatzu Chiu, Yumiko Masukagami, Koutarou Nishimura, Hunter Barbee, Hiroshi Takase, Shinju Sugiyama, Yuta Yamazaki, et al. Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts. Nature aging. 2024

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MISC (80)：

大森徳貴, 城村由和. 【マルチオミクスデータ駆動時代の疾患研究がん、老化、生活習慣病最新のオミクス統合で挑む標的探索と病態解明】(第3章)各分野におけるマルチオミクス研究マルチオミクス解析によるセノリティクス戦略. 実験医学. 2023. 41. 15. 2524-2530
馬場智久, 城村由和. Therapeutic approaches by targeting cellular senescence. 月刊腫瘍内科. 2023. 32. 4
大森徳貴, 大森徳貴, 城村由和, 城村由和. Removal of senescent cells by small molecules-Current status and future perspectives. 医学のあゆみ. 2023. 287. 5
中野泰博, 城村由和. Senolytics by senescent cell-specific metabolism inhibition. 月刊細胞. 2023. 55. 2
大森徳貴, 大森徳貴, 城村由和, 城村由和. Discovering senolytics with multi-omics analysis. 実験医学. 2023. 41. 15

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Patents (2)：

Education (2)：

Professional career (1)：

Work history (5)：

2022/04 - 現在 Kanazawa University Cancer Research Institute Professor
2016/08 - 2022/03 The University of Tokyo The Institute of Medical Science Assistant Professor
2011/05 - 2016/07 Nagoya City University Graduate School of Medical Sciences Assistant Professor
2008/11 - 2011/04 National Institute of Health National Cancer Institute
2008/04 - 2008/10 Nagoya City University Graduate School of Pharmaceutical Sciences Research associate

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