Rchr
J-GLOBAL ID：201101076670010662   Update date: Feb. 01, 2024

Harada Takeshi

ハラダ タケシ | Harada Takeshi
Affiliation and department：
Osaka University Graduate School of Medicine

About Osaka University Graduate School of Medicine


Research field  (1)： Cell biology
Research keywords  (11)： Arl4c ,  CKAP4 ,  Wnt ,  グルタミン酸受容体 ,  発がん ,  シグナル伝達 ,  MEK ,  ERK ,  低分子量Gタンパク質 ,  MAPキナーゼ ,  ノックアウトマウス
Research theme for competitive and other funds  (11)：
  • 2020 - 2023 II型膜タンパク質CKAP4の個体レベルでの機能解析
  • 2017 - 2020 In vivo imaging of a secreted glycoprotein, Wnt5a
  • 2016 - 2017 Wnt5aシグナルネットワークの異常によるがんと炎症の悪性化の分子機構の解明
  • 2010 - 2012 Roles of mTOR in neuronal development, synaptic plasticity and learning and memory
  • 2006 - 2007 Neuronal development and synaptic plasticity in Cdc42 cenditional knockout mice
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Papers (20)：
  • Hiroshi Kishimoto, Masayoshi Iwasaki, Kensaku Wada, Keita Horitani, Osamu Tsukamoto, Kenta Kamikubo, Seitaro Nomura, Shinji Matsumoto, Takeshi Harada, Daisuke Motooka, et al. Wnt5a-YAP signaling axis mediates mechanotransduction in cardiac myocytes and contributes to contractile dysfunction induced by pressure overload. iScience. 2023. 107146-107146
  • Takeshi Harada, Ryota Sada, Yoshito Osugi, Shinji Matsumoto, Tomoki Matsuda, Mitsuko Hayashi-Nishino, Takeharu Nagai, Akihiro Harada, Akira Kikuchi. Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER-mitochondria contact sites. Journal of Cell Science. 2020. 133. 21. jcs249045-jcs249045
  • Kenji Kimura, Shinji Matsumoto, Takeshi Harada, Eiichi Morii, Izumi Nagatomo, Yasushi Shintani, Akira Kikuchi. ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target. Cancer science. 2020. 111. 3. 951-961
  • Wakako Kumita, Kenya Sato, Yasuhiro Suzuki, Yoko Kurotaki, Takeshi Harada, Yang Zhou, Noriyuki Kishi, Kengo Sato, Atsu Aiba, Yasubumi Sakakibara, et al. Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing. Scientific reports. 2019. 9. 1. 12719-12719
  • Hirokazu Kimura, Hideki Yamamoto, Takeshi Harada, Katsumi Fumoto, Yoshihito Osugi, Ryota Sada, Natsumi Maehara, Hayato Hikita, Soichiro Mori, Hidetoshi Eguchi, et al. CKAP4, a DKK1 Receptor, Is a Biomarker in Exosomes Derived from Pancreatic Cancer and a Molecular Target for Therapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2019. 25. 6. 1936-1947
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MISC (22)：
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Work history (4)：
  • 2014/05 - 現在 Osaka University Graduate School of Medicine
  • 2009/09 - 2014/04 The University of Tokyo
  • 2007 - 2009/08 神戸大学 大学院医学系研究科 分子遺伝学 助教
  • 2003 - 2007 神戸大学 大学院医学研究科 細胞生物学 助手
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