Research field (2)：
Functional biochemistry
, Molecular biology
Research keywords (2)：
リン脂質スクランブリング
, 細胞骨格
Research theme for competitive and other funds (6)：
2023 - 2026 Establishment of a comprehensive screening system to elucidate the regulatory mechanism of scramblase Xkr4.
2022 - 2026 シナプス刈込による感覚統合の制御とその破綻による発達障害
2020 - 2023 pHストレス適応を司るpH誘導型転写因子の実体解明
2020 - 2023 Analysis of the regulatory mechanism of Xkr4 scramblase activity
2016 - 2018 Identification and functional analysis of a novel Nectin-mediated cell-adhesion apparatus
2008 - 2009 c-Ablの機能的複合体形成における動的活性制御機構の解析
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Papers (22)：
Yuki Noguchi, Masahiro Maruoka, Jun Suzuki. Protocol for in vivo CRISPR screening targeting murine testicular cells. STAR protocols. 2024. 5. 3. 103306-103306
Han Niu, Masahiro Maruoka, Yuki Noguchi, Hidetaka Kosako, Jun Suzuki. Phospholipid scrambling induced by an ion channel/metabolite transporter complex. Nature communications. 2024. 15. 1. 7566-7566
Yuki Noguchi, Yasuhito Onodera, Tatsuo Miyamoto, Masahiro Maruoka, Hidetaka Kosako, Jun Suzuki. In vivo CRISPR screening directly targeting testicular cells. Cell genomics. 2024. 100510-100510
Panpan Zhang, Masahiro Maruoka, Ryo Suzuki, Hikaru Katani, Yu Dou, Daniel M. Packwood, Hidetaka Kosako, Motomu Tanaka, Jun Suzuki. Extracellular calcium functions as a molecular glue for transmembrane helices to activate the scramblase Xkr4. Nature Communications. 2023. 14. 1
Masahiro Maruoka, Panpan Zhang, Hiromi Mori, Eiichi Imanishi, Daniel M Packwood, Hiroshi Harada, Hidetaka Kosako, Jun Suzuki. Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane. Molecular cell. 2021. 81. 7. 1397-1410
Adaptor Proteins and Cancer
Transworld research network 2008
Lectures and oral presentations (7)：
Regulation of Membrane Lipid Dynamics by Scramblase Xkr4
(MBSJ2023 2023)
Regulation of scramblase Xkr4 on the plasma membrane by its interaction with the organelle.
(2022)
Regulatory mechanism and role of scramblase Xkr4
(The 74th Annual Meeting of the Japan Society for Cell Biology 2022)
スクランブラーゼXkr4の活性制御機構
(第29回Cell death学会学術集会 2021)
ctin-4 stimulates prolactin receptor signaling by preventing SOCS1-mediated feedback inhibition during the development of mammary gland
(ConBio2017 2017)
