Rchr
J-GLOBAL ID:201101080852495928
Update date: Nov. 07, 2024
Furuya Shigeki
Furuya Shigeki
Affiliation and department:
Job title:
Professor
Research field (3):
Nutrition and health science
, Food sciences
, Neuroscience - general
Research keywords (17):
food protein-derived peptide
, 神経細胞
, 代謝疾患モデルマウス
, 細胞間相互作用
, アストロサイト
, 脳
, 細胞増殖
, 神経幹細胞
, 小脳
, 神経発生
, グリア
, 神経栄養因子
, アミノ酸
, ノックアウトマウス
, セラミド
, セリン
, プルキンエ細胞
Research theme for competitive and other funds (22):
- 2018 - 2022 Molecular basis underlying regulation of synapse-related protein expression and higher brain functions by maternal protein nutrition.
- 2018 - 2021 Functional significance of the mitochondria-based intracellular metabolic network regulated by de novo synthesized serine.
- 2015 - 2019 Comprehensive phenotypic analysis of liver-specific Phgdh deficient mice
- 2015 - 2018 Enzymatic synthesis of novel rutinoside and its neuroprotective properties
- 2014 - 2017 Physiological roles of liver de novo serine biosynthesis in adaptation to protein starvation
- 2014 - 2017 Early protein restriction impacts gene/protein expression and function in mature brain
- 2010 - 2012 Comparative studies on the risk of sensorimotor gating deficits in animal models of early amino acid/protein malnutrition.
- 2008 - 2010 Search for Novel Functionalities of Amino Acids as Bio-regulatory Factors and Verification of Their Usefulness
- 2006 - 2008 Glial expression of 3-phosphoglycerate dehydrogenase for L-serine biosynthesis in the retina
- 2006 - 2008 L、Dーセリン代謝連関システムによる神経機能制御の遺伝子改変マウス解析基盤形成
- 2000 - 2004 細胞の生存と死におけるスフィンゴ糖脂質の役割
- 2002 - 2003 Functional analysis of mouse 3-phosphoglycerate dehydrogenase (Phgdh) gene by using gene targeting
- 2000 - 2001 NEW HORIZON OF NEURON-ASTROCYTE INTERACTION : NEUROTROPHICACTIVITY OF L-SERINE
- 1997 - 1999 Molecular characterization of membrane sphingolipid function
- 1997 - 1998 小脳プルキンエ細胞樹状突起分岐形成に関与する遺伝子群の単離と機能解析
- 1996 - 1997 Regulation mechanism of synaptic input to Purkinje cell and LTD
- 1996 - 1996 セラミドによる小脳プルキンエ細胞樹状突起形成制御の分子機構
- 1995 - 1995 小脳プルキンエ細胞樹状突起におけるスフィンゴ脂質を介した情報伝達機構
- 1995 - 1995 小脳プルキンエ細胞における可塑性分子機構と新規情報分子-スフィンゴ脂質-
- 1994 - 1994 ヘパラン硫酸グリコサミノグリカンの初期発生における機能の解析
- 1993 - 1994 New approaches of glyco-neurobiology
- 1993 - 1993 初期胚神経系細胞で特異的に発現している複合糖鎖の機能解析
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Papers (78):
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Yohei Hayashi, Jintaro Kaneko, Yumi Ito-Matsuoka, Asuka Takehara, Mayuka Funakoshi, So Maezawa, Kenjiro Shirane, Shigeki Furuya, Yasuhisa Matsui. Control of epigenomic landscape and development of fetal male germ cells through L-serine metabolism. iScience. 2024. 27. 9. 110702-110702
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Esther W Lim, Regis J Fallon, Caleb Bates, Yoichiro Ideguchi, Takayuki Nagasaki, Michal K Handzlik, Emeline Joulia, Roberto Bonelli, Courtney R Green, Brendan R E Ansell, et al. Serine and glycine physiology reversibly modulate retinal and peripheral nerve function. Cell metabolism. 2024
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Akira Wada, Hayato Yamashita, Ayaka Togashi, Shunsuke Ogawa, Arashi Muroi, Satoshi Kido, Shigeki Furuya. Combination of Parenteral Amino Acid Infusion and Intermittent Loading Exercise Ameliorates Progression of Postoperative Sarcopenia in Rat Model. Nutrients. 2024. 16. 8
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Momoko Hamano, Takashi Ichinose, Tokio Yasuda, Tomoko Ishijima, Shinji Okada, Keiko Abe, Kosuke Tashiro, Shigeki Furuya. Bioinformatics Analysis of the Molecular Networks Associated with the Amelioration of Aberrant Gene Expression by a Tyr-Trp Dipeptide in Brains Treated with the Amyloid-β Peptide. Nutrients. 2023. 15. 12. 2731-2731
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Wazifa Afrin, Naotaka Yamada, Shigeki Furuya, Kohji Yamamoto. Characterization of glutathione-specific gamma glutamyl cyclotransferase (ChaC) in Bombyx mori. Archives of insect biochemistry and physiology. 2023. 114. 1. e22027
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MISC (48):
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古屋 茂樹. 栄養素による脳機能制御の分子機構と疾患との関連 セリン合成不全による脳高次機能制御異常と神経変性. 日本栄養・食糧学会大会講演要旨集. 2019. 73回. 162-162
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胡 雅テイ, 河野 唯, 佐々木 真宏, 古屋 茂樹. セリシン経口投与によるマウス脳内における神経伝達物質代謝への影響. 日本栄養・食糧学会大会講演要旨集. 2019. 73回. 301-301
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北野 楽, 名井 典乃子, 日比 亜佑実, 最上 侑佑盛, 古屋 茂樹. 発達期低タンパク質栄養による次世代成熟期脳内神経伝達物質代謝異常. アミノ酸研究. 2019. 12. 2. 126-126
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松元 沙樹, 日野 由佳子, 小柳 歩美, 古澤 和佳, 市瀬 嵩志, 前渕 元宏, 古屋 茂樹. 大豆ペプチド亜慢性投与による脳神経保護作用の老齢及び若齢マウスでの比較解析. アミノ酸研究. 2019. 12. 2. 129-129
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濱野 桃子, 佐藤 和貴, 河野 唯, 名井 典乃子, 原口 祐里奈, 立川 正憲, 古屋 茂樹. 脳内セリン充足度の低下が脳高次機能障害を惹起する分子機序のプロテオーム解析. アミノ酸研究. 2019. 12. 2. 139-140
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Professional career (1):
- Ph.D. (Kyushu University)
Work history (6):
Awards (1):
- 2021/10 - Japanese Society for Amino Acid Sciences JSAAS Award 2021 for Distinguished Investigator Elucidating the essential role for de novo serine biosynthesis and its molecular basis in the survival and development of mammals.
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