Research field (2)：
Neuroanatomy and physiology
, Pathobiochemistry
Research theme for competitive and other funds (6)：
2022 - 2025 多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発
2020 - 2023 異常凝集体に対する体外診断法開発によるアルツハイマー病の早期診断と病態解明
2017 - 2020 Propagation of Alzheimer's disease neuronal cell death by intracellular formation and secretion of abnormal aggregates
2014 - 2017 Elucidation of a neurodegenerative mechanism induced by a new Alzheimer's disease drug target and its inhibition
2011 - 2014 A study on the molecular mechanisms of neurodegeneration induced by high-mass amyloid-beta assembly, amylospheroids (ASPD)
2004 - 2005 Elucidation of the neurodegenerative mechanism induced by amylospheroid
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Papers (30)：
Tomoya Sasahara, Minako Hoshi. High-throughput screening for agonists of ROS production in live human vascular endothelial cells. STAR protocols. 2022. 3. 1. 101053-101053
Tomoya Sasahara, Kaori Satomura, Mari Tada, Akiyoshi Kakita, Minako Hoshi. Alzheimer's Aβ assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells. iScience. 2021. 24. 9. 102936-102936
Minako Hoshi. Multi-angle development of therapeutic methods for Alzheimer's disease. (cover). British journal of pharmacology. 2021. 178. 4. 770-783
Enlightening Protein Assembly Pathways Leading to Alzheimer Disease
(IBRI Mini-Workshop on amyloid-beta protein oligomer amyloid-beta protein assembly “Deciphering the mystery of amyloid-beta protein assembly.”, organized by Professors Hiroaki and Hoshi 2011)
A new toxic target for a high-mass amyloid β-protein assembly with a unique toxic structure
(“International conference on Alzheimer’s disease: Return to the Basics”, organized by Professors Iwata and Hoshi 2011)
High-mass amyloid beta-protein assembly with a unique toxic surface from Alzheimer's disease brains
(“Prion and Virus Infections”, organized by Drs. Nagayama, Sokabe and Kataoka 2009)
