Sato Moritoshi

Affiliation and department：
Homepage URL (1)： http://system.c.u-tokyo.ac.jp/common/professor/sato.html

Research field (3)： Molecular biochemistry , Biochemistry , Analytical chemistry

Research keywords (31)：包括脳ネットワーク , 蛋白質間相互作用 , 走査型トンネル顕微鏡(STM) , タンパク質リン酸化 , 蛋白質リン酸化 , セカンドメッセンジャー , エンドサイトーシス , プローブ , 動脈硬化 , 細胞ターゲティング , YFP , ホスファチジルイノシトール-3,4,5-三リン酸 , G蛋白質 , GPCR , 疾患細胞 , PIP_3 , 早期治療 , 細胞内情報伝達 , CFP , マトリクスメタロプロテアーゼ , エフェクター , スカベンジャー受容体 , DAG , 早期診断 , PIP3 , FRET , GFP , 蛍光プローブ分子 , 蛍光共鳴エネルギー移動 , 蛍光プローブ , 脂質セカンドメッセンジャー

Research theme for competitive and other funds (29)：

2022 - 2024 時空間制御CRISPR-Cas3の開発および生体内ゲノム改変への応用
2021 - 2024 新たな光スイッチタンパク質の開発に基づく遺伝子および細胞機能の光操作技術の創出
2021 - 2024 血管の組織修復における細胞間相互作用の解明
2020 - 2023 光活性型Creシステムを利用した生体内遺伝子操作法の開発
2020 - 2023 Optogenetic regulation of function, regeneration and diseases of the female reproductive organ using stem cell and genome editing technologies

2019 - 2022 近赤外光によるゲノムの光操作技術の創出

2018 - 2021 Exploration of novel in vitro lethal arrhythmia models with 3D tissues from human iPS cells

2018 - 2021 Cell analysis based on optical control of the genome

2017 - 2021 Molecular understanding of the accumulation of mesenchymal stem cells in vivo by photo-manipulation techniques and its application to bone-related diseases

2017 - 2019 Development of a method to optically control heterotrimeric G-proteins

2015 - 2018 Fluorescent probes for live-cell super-resolution imaging

2013 - 2018 Molecular and neural bases of memory dynamism in Drosophila

2013 - 2018 Principles of memory dynamics elucidated from a diversity of learning systems

2015 - 2017 Fluorescent memory proteins

2012 - 2017 Creation of Bright Near-Infrared Bioluminescent Probes and Their Application to Tumor Imaging

2013 - 2015 細胞膜でのシグナル伝達を探索する遺伝子コード型分子プローブ

2013 - 2015 Development of optical indicators for reactive oxygen species

2012 - 2015 Fluorescent probes to visualize molecular processes in the cell

2008 - 2014 Systems molecular ethology to understand the operating principle of the nervous system

2012 - 2012 革新的高輝度近赤外発光イメージングプローブの創製

2011 - 2012 Molecular probes to visualize cellular processes in vivo

2008 - 2012 Genetically encoded probes for imaging molecular processes in vivo

2009 - 2010 生体情報分子の細胞内局所的ノックダウンプローブの創製

2008 - 2010 Development of degradable probes

2007 - 2008 細胞機能を制御する分子の創製

2003 - 2007 New Analytical Methods for Molecular Imaging in Single Live Cells and Interfacial Molecular Assemblies

2003 - 2004 生きた細胞内のG蛋白質情報伝達の活性化を可視化する蛍光プローブ分子

2001 - 2002 細胞内の脂質セカンドメッセンジャーの蛍光プローブ分子

2001 - 2002 Intracellular fluorescent probes for chemical processes in single living cells

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Papers (20)：

Yuta Koganezawa, Yuichi Wakamoto, Moritoshi Sato, Miki Umetani. Detecting Photoactivatable Cre-mediated Gene Deletion Efficiency in Escherichia coli. BIO-PROTOCOL. 2023. 13. 11
Yuto Kuwasaki, Kazushi Suzuki, Gaigai Yu, Shota Yamamoto, Takahiro Otabe, Yuki Kakihara, Michiru Nishiwaki, Keita Miyake, Keiji Fushimi, Ramsey Bekdash, et al. A red light-responsive photoswitch for deep tissue optogenetics. Nature biotechnology. 2022. 40. 11. 1672-1679
Yuta Koganezawa, Miki Umetani, Moritoshi Sato, Yuichi Wakamoto. History-dependent physiological adaptation to lethal genetic modification under antibiotic exposure. eLife. 2022. 11
Kanae Kishi, Hiroshi Koyama, Sanae Oka, Azusa Kato, Moritoshi Sato, Toshihiko Fujimori. Repetitive short-pulsed illumination efficiently activates photoactivatable-Cre as continuous illumination in embryonic stem cells and pre-implantation embryos of transgenic mouse. genesis. 2021
Sean R Tachibana, Longteng Tang, Liangdong Zhu, Yuka Takeda, Keiji Fushimi, Yoshibumi Ueda, Takahiro Nakajima, Yuto Kuwasaki, Moritoshi Sato, Rei Narikawa, et al. An Engineered Biliverdin-Compatible Cyanobacteriochrome Enables a Unique Ultrafast Reversible Photoswitching Pathway. International journal of molecular sciences. 2021. 22. 10

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MISC (6)：

Takahiro Nakajima, Moritoshi Sato. Cell-based fluorescent indicators to visualize secretion of picomolar concentrations of biological substances from living cells. Bunseki Kagaku. 2009. 58. 6. 425-434
佐藤守俊. 細胞内の分子動態を可視化する. バイオサイエンスとインダストリー = Bioscience & industry. 2008. 66. 11. 596-597
Moritoshi Sato. Methods to visualize molecular processes in living cells based on genetically encoded fluorescent indicators. Bunseki Kagaku. 2008. 57. 4. 219-226
佐藤守俊. 脂質の細胞内動態を可視化計測するFRETプローブ (特集細胞機構を可視化する新機能蛍光プローブ--リン酸化,活性酸素,グルタミン酸,脂質,糖質,シグナル伝達のイメージング). バイオテクノロジージャーナル. 2007. 7. 6. 670-675
Imaging molecular processes in living cells. Protein, nucleic acid and enzyme. 2007. 52. 13. 1568-1574

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Professional career (1)：

博士(理学)

Work history (4)：

2017 - 現在 The University of Tokyo Graduate School of Arts and Sciences
2007 - 2017 The University of Tokyo Graduate School of Arts and Sciences
2005 - 2007 The University of Tokyo Graduate School of Science
2000 - 2005 The University of Tokyo Graduate School of Science

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