Rchr
J-GLOBAL ID:201101088672850321
Update date: Nov. 08, 2024
Hirose Kenzo
ヒロセ ケンゾウ | Hirose Kenzo
Affiliation and department:
Job title:
教授
Research field (6):
Neuroscience - general
, Chemical biology
, Pharmaceuticals - chemistry and drug development
, Clinical pharmacy
, Physiology
, Pharmacology
Research keywords (30):
蛍光プローブ
, 超分子
, STORM
, 蛍光イメージング
, 蛍光色素
, superresolution microscopy
, グルタミン酸
, 細胞・組織
, 蛍光測定
, GFP
, トランスジェニック
, ゲノム
, バイオテクノロジー
, ナノシステム
, I P_3
, イノシトールリン脂質
, スクリーニング
, カルシウムストア
, RNAi
, LTD
, ホスホイノシタイド
, シナプス
, シナプス可塑性
, 蛍光
, 長期増強
, 中枢神経
, 小脳
, プルキンエ細胞
, IP3
, カルシウム
Research theme for competitive and other funds (22):
- 2023 - 2027 Enhancement of antidepressant responsiveness by stress via reorganization of noradrenergic signaling
- 2022 - 2025 時間窓を拡張した次世代型単分子in vivoイメージングの実現
- 2020 - 2023 Nano-level transformation of the fine arrangement of synaptic molecules elicited by learning and environmental changes
- 2019 - 2021 Development of the fluorescent probe technology for live-cell super-resolution imaging
- 2017 - 2020 Development of fluorescence imaging technology for central catecholamines
- 2015 - 2017 tudy of pathological mechanism underlying autism by focusing on nanoscale distribution of synaptic molecules
- 2012 - 2017 Transformation of the relationship between synaptic supramolecular assemblies and synaptic function in mental disorder
- 2012 - 2017 Unraveling the micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels
- 2012 - 2015 Analysis of dynamics of synaptically released glutamate in cortical neurons
- 2008 - 2010 Investigation of signal correlation and integration in ICC pacemaking
- 2004 - 2009 Regulation of Bio-nanosystems
- 2007 - 2008 長期増強現象を担うPDZドメイン含有蛋白質の網羅的分子スクリーニング法の開発
- 2007 - 2008 Visualization analysis of spatiotemporal dynamics of glutamate in central nervous system
- 2006 - 2008 Regulation of intracellular magnesium concentration
- 2004 - 2008 Integration of intracellular nanosystems in calcium signaling
- 2005 - 2006 大規模RNAiライブラリーを用いたカルシウム流入分子機構の網羅的探索
- 2003 - 2004 味細胞内情報伝達のin situイメージング法による甘味感知の分子機構の解明
- 2003 - 2004 LTD and spatio-temporal dynamics of IP_3 within cerebellar Purkinje cells
- 2000 - 2004 細胞内シグナルフローの可視化解析
- 2001 - 2003 Development of novel caged compounds that can report the yield of uncaged products
- 2001 - 2002 Role of IP_3 in LTD in cerebellar purkinje cells
- 1998 - 1999 リアルタイム可視化によるプレクストリン相同ドメインの機能解析
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Papers (80):
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Yimeng Wang, Siyu Cao, Daisuke Tone, Hiroshi Fujishima, Rikuhiro G. Yamada, Rei-ichiro Ohno, Shoi Shi, Kyoko Matsuzawa, Saori Yada, Mari Kaneko, et al. Postsynaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles. Nature. 2024
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Rinako Miyano, Hirokazu Sakamoto, Kenzo Hirose, Takeshi Sakaba. RIM-BP2 regulates Ca2+ channel abundance and neurotransmitter release at hippocampal mossy fiber terminals. eLife. 2024. 12
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Rinako Miyano, Hirokazu Sakamoto, Kenzo Hirose, Takeshi Sakaba. RIM-BP2 is required for rapid neurotransmitter release through regulation of Ca2+ channel clustering at hippocampal mossy fiber terminals. 2023
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Ryota Fukaya, Himawari Hirai, Hirokazu Sakamoto, Yuki Hashimotodani, Kenzo Hirose, Takeshi Sakaba. Increased vesicle fusion competence underlies long-term potentiation at hippocampal mossy fiber synapses. Science Advances. 2023. 9. 8
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Hirokazu Sakamoto, Naoya Kimpara, Shigeyuki Namiki, Shun Hamada, Toshihisa Ohtsuka, Kenzo Hirose. Synapse type-specific molecular nanoconfigurations of the presynaptic active zone in the hippocampus identified by systematic nanoscopy. 2022
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MISC (126):
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並木繁行, 浅沼大祐, 大久保洋平, 廣瀬謙造. ナノスケールの視点から脳の分子ダイナミクスの再考を目指す蛍光再生型分子標識技術開発. 日本解剖学会総会・全国学術集会抄録集(CD-ROM). 2023. 128th
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坂本寛和, 廣瀬謙造. Nanoscopy imaging of synaptic molecules by single-molecule localization microscopy. Bio Clinica. 2022. 37. 11
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小島佑介, 坂本寛和, 並木繁行, 廣瀬謙造. シナプス小胞放出サイトの形成に関わるMunc13-1とアクティブゾーンタンパク質の相互作用の同定. 日本神経化学会大会抄録集(Web). 2022. 65th
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大西泰地, 坂本寛和, 大久保洋平, 並木繁行, 廣瀬謙造. 恐怖記憶の形成に関与するシナプスの検出法の開発. 日本神経化学会大会抄録集(Web). 2022. 65th
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並木繁行, 浅沼大祐, 大久保洋平, 廣瀬謙造. 新規蛍光スイッチングプローブによるライブセル超解像イメージング法の開発. 日本薬理学雑誌. 2020. 155. Supplement
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Professional career (1):
Work history (8):
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