Research field (7):
Digestive surgery
, Obstetrics and gynecology
, Pharmacology
, Cardiology
, Urology
, Metabolism and endocrinology
, Pathobiochemistry
2021 - 2024 Roles of a mitochondrial respiratory supercomplex assembly factor Cox7rp in cells, organs and health
2021 - 2024 Functional analysis of sex hormones regulating cancer heterogeneity and microenvironment through respiratory supercomplexes
2020 - 2022 Roles of super-enhancers in patient-derived prostate cancer cells and xenografts.
2019 - 2022 Discovery of PI polyamide targeting androgen receptor collaborative transcriptional factor in castration-resistant prostate cancer
2017 - 2020 Investigation on the breast cancer-promoting effects of TRIM family proteins and its clinical application
2016 - 2020 Identification of the factors associated with frailty in the elderly
2018 - 2019 がん悪性化を担うRNA制御メカニズムの包括的解明と革新的創薬
2015 - 2018 The elucidation on androgen signaling pathway in prostate cancer and development of its targeting drug
2015 - 2018 Personalized medicine for advanced prostate cancer
2015 - 2017 Study of physiological and phatophysiological functions of mitochondria supercomplex
2015 - 2017 Functional analyses of mitochondrial roles in hormone-dependent cancer using new technologies
2014 - 2017 Elucidation of estrogen receptor-mediated transcription regulatory systems and downstream signaling pathways in breast cancer and clinical application to cancer management
2016 - 2017 がん関連RNA結合タンパク質複合体を標的とした革新的治療法の開発
2013 - 2016 Identification of locomotive and metabolic syndrome-related genes by genome wide association and functional analysis
2013 - 2015 Analysis of androgen-regulated natural antisense RNA for the diagnosis and treatment of prostate cancer
2012 - 2015 Individualized medicine in the treatment of human prostate cancer using laser-captured microdissection technique
2011 - 2015 Next generation sequencing-based elucidation of novel hormone action targets for geriatric diseases and application for anti-aging medicine
2015 - 2015 ノンコーディングRNAを標的とした革新的がん医療シーズ
2012 - 2014 Roles of vitamin K action through the protein modification and transcriptional activation via the nuclear receptor
Kaoru Sato, Ken-ichi Takayama, Yuko Saito, Satoshi Inoue. ERRα and ERRγ coordinate expression of genes associated with Alzheimer’s disease, inhibiting DKK1 to suppress tau phosphorylation. Proceedings of the National Academy of Sciences. 2024. 121. 37
Ken-Ichi Takayama, Takashi Suzuki, Kaoru Sato, Yuko Saito, Satoshi Inoue. Cooperative nuclear action of RNA-binding proteins PSF and G3BP2 to sustain neuronal cell viability is decreased in aging and dementia. Aging cell. 2024. e14316
Daisuke Obinata, Kenichi Takayama, Mitchell G Lawrence, Daigo Funakoshi, Makoto Hara, Birunthi Niranjan, Linda Teng, Renea A Taylor, Gail P Risbridger, Satoru Takahashi, et al. Patient-derived castration-resistant prostate cancer model revealed CTBP2 upregulation mediated by OCT1 and androgen receptor. BMC cancer. 2024. 24. 1. 554-554