Kazuya Iwamoto

イワモトカズヤ | Kazuya Iwamoto

Affiliation and department：
Job title： Professor

Research field (1)： Psychiatry

Research keywords (25)：遺伝学 , 遺伝子 , ゲノム , 脳神経疾患 , 発現制御 , HTR2C , RNA editing , 躁うつ病 , コカイン , 遺伝子発現 , 鬱病 , リンパ芽球 , 双生児 , 躁鬱病 , DNAメチレーション , セロトニン , タイリングアレイ , 鬱病動物モデル , エピジェネティクス , 精神疾患 , DNAメチル化 , 双極性障害 , DNAマイクロアレイ , 死後脳 , 統合失調症

Research theme for competitive and other funds (22)：

2023 - 2027 Stratification of depression based on lysophospholipid metabolic disorders and innovative development of novel antidepressants
2022 - 2025 脳発達期の栄養恒常性破綻による統合失調症病態形成メカニズムの解明
2018 - 2023 Understanding the schizophrenia-related neural circuits based on transposon dynamics
2018 - 2023 マルチスケール精神病態の構成的理解(総括班)
2018 - 2022 Analysis of somatic mutations in brains of patients with psychiatric disorders

2017 - 2019 初期神経発生過程に生じる体細胞変異の頻度とパターンの解析

2015 - 2018 Development of techniques for analyzing somatic mutations in single neurons of psychiatric disorders

2015 - 2018 Detection of novel LINE-1 insertion in prefrontal cortex of patients with schizophrenia

2015 - 2018 Analysis of LINE-1 retrotransposition using poly(I:C) animal model

2015 - 2017 Identifying common and distinctive epigenetic biomarkers for schizophrenia and bipolar disorder

2014 - 2017 Social function recovery in schizophrenia: brain mechanism of empathy/concerning function using stem cells and oxytocin

2012 - 2017 Genomic and epigenomic analyses of neuronal cells of psychiatric disorders

2012 - 2017 Unraveling the micro-endophenotypes of psychiatric disorders at the molecular, cellular and circuit levels

2013 - 2015 Serotonin transporter gene-linked promotor-polymorphism and DNA methylation involved in personalized impulsivity

2012 - 2015 Genome mapping of 5-hydroxymethylcytosine using human postmortem brains

2012 - 2015 Comprehensive analysis of the effect of antipsychotics on DNA methylation in brain

2010 - 2012 Analysis of L1 retrotransposition activity in the brains of patients with psychiatric disorders.

2008 - 2010 Integrative genomic analyses for understanding the systematic gene expression changes in the brains of patients with psychiatric disorders

2007 - 2008 精神発達障害緩和分子同定のための一卵性双生児間エピゲノム比較アプローチ

2006 - 2007 精神疾患患者死後脳のDNAメチル化状態の網羅的解析

2004 - 2005 躁うつ病および統合失調症患者におけるepigeneticな変異の網羅的探索

2002 - 2003 ヒト死後脳・動物モデルを用いた精神疾患におけるRNA-editingの影響評価

Show all

Papers (109)：

Jianbin Du, Yutaka Nakachi, Yui Murata, Emi Kiyota, Tadafumi Kato, Miki Bundo, Kazuya Iwamoto. Exploration of cell type-specific somatic mutations in schizophrenia and the impact of maternal immune activation on the somatic mutation profile in the brain. Psychiatry and Clinical Neurosciences. 2024
Hiroko Sugawara, Akitoshi Date, Satoshi Fuke, Yutaka Nakachi, Tadafumi Kato, Minoru Narita, Miki Bundo, Kazuya Iwamoto. Quantification of cytosine modifications in the aged mouse brain. Neuropsychopharmacology Reports. 2023
Yoshifumi Baba, Noriko Yasuda, Miki Bundo, Yutaka Nakachi, Junko Ueda, Takatsugu Ishimoto, Masaaki Iwatsuki, Yuji Miyamoto, Naoya Yoshida, Hiroyuki Oshiumi, et al. LINE-1 hypomethylation, increased retrotransposition and tumor-specific insertion in upper gastrointestinal cancer. Cancer Science. 2023
Naoto Kajitani, Mami Okada-Tsuchioka, Asuka Inoue, Kanako Miyano, Takeshi Masuda, Shuken Boku, Kazuya Iwamoto, Sumio Ohtsuki, Yasuhito Uezono, Junken Aoki, et al. G protein-biased LPAR1 agonism of prototypic antidepressants: Implication in the identification of novel therapeutic target for depression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023
Shinya Fujii, Yui Murata, Yuko Imamura, Yutaka Nakachi, Miki Bundo, Mie Kubota-Sakashita, Tadafumi Kato, Kazuya Iwamoto. Sex-dependent behavioral alterations in a poly(I:C)-induced maternal immune activation mouse model without segment filamentous bacteria. Neuroscience Letters. 2023. 137467-137467

ｍore...

MISC (161)：

村田唯, 藤飯慎也, 岩本和也. 【精神疾患と早期ライフステージイベントの関連】母体免疫活性化動物モデルにおける脳神経系LINE-1動態の解析. 日本生物学的精神医学会誌. 2021. 32. 3. 141-143
村田唯, 岩本和也. 【ストレスと神経系】ストレスの神経機構(動物実験を中心に) ストレスのエピゲノム研究. Clinical Neuroscience. 2021. 39. 6. 737-739
岩本和也, 文東美紀, 加藤忠史. 【精神疾患の網羅的ゲノム解析〜課題と展望】精神疾患のエピジェネティクス研究双極性障害死後脳のDNAメチル化解析から. 日本生物学的精神医学会誌. 2021. 32. 2. 64-67
文東美紀, 清田恵美, 岩本和也. 【1細胞解析-技術と応用】応用精神疾患患者試料を使用した1細胞研究の現在. 医学のあゆみ. 2021. 276. 10. 1022-1026
FUJII Shinya, MURATA Yui, BUNDO Miki, NAKACHI Yutaka, ARAKI Kimi, IWAMOTO Kazuya. Development of new mouse line for monitoring LINE-1 retrotransposition. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th

ｍore...

Professional career (1)：

博士(理学)

Awards (2)：

2016/07 - 日本神経薬理学会第5回学術奨励賞
2006/03 - CINP Rafaelsen Young Investigators Award

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page