Rchr
J-GLOBAL ID:201101091367878012   Update date: Oct. 10, 2024

Hitoshi Seiji

Hitoshi Seiji
Affiliation and department:
Job title: Professor
Homepage URL  (2): http://www.shiga-med.ac.jp/~hqphysi1/index.htmlhttp://www.shiga-med.ac.jp/~hqphysi1/physiol1/english.html
Research field  (2): Neurology ,  Neuroscience - general
Research keywords  (32): 包括脳ネットワーク ,  統合脳・病態脳 ,  テトラサイクリン誘導システム ,  海馬 ,  情動 ,  神経細胞新生 ,  脳室下層 ,  Sp1 ,  強制水泳 ,  Flk1 ,  LewisX抗原 ,  Neurosphere ,  Neuroshere assay ,  糖鎖 ,  Fibroblast growth factor-2 ,  ES細胞 ,  α1,2フコース転移酵素遺伝子 ,  自己複製能 ,  プロモーター領域 ,  ストレス ,  気分安定薬 ,  バルプロ酸 ,  カルバマゼピン ,  リチウム ,  双極性気分障害 ,  Epiblast ,  Leukemia inhibitory factor ,  転写因子 ,  ノックアウトマウス ,  未分化神経幹細胞 ,  Notchシグナル ,  神経幹細胞
Research theme for competitive and other funds  (23):
  • 2022 - 2025 ALSモデルカニクイザルを用いた超早期病態解明および治療戦略構築
  • 2016 - 2019 Molecular mechanisms of the fate determination of neural stem cells
  • 2016 - 2019 Generation of neurodegenerative disease model macaques
  • 2014 - 2016 α1,3フコース転移酵素Fut10による幹細胞の未分化性維持機構の解明
  • 2013 - 2016 Analysis of DNA demethylation by Glial cells missing genes
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Papers (77):
  • Asmaa Abdullah, Yoshitaka Hayashi, Naoko Morimura, Seiji Hitoshi. Role of α1,3-fucosyltransferases in the mammalian brain and their association with neuropsychiatric disorders. Trends in Glycoscience and Glycotechnology. 2024. 36. 212. E74-E77
  • Zakiyyah Munirah Mohd Zaki, Anri Kuroda, Naoko Morimura, Yoshitaka Hayashi, Seiji Hitoshi. Depletion of transit amplifying cells in the adult brain does not affect quiescent neural stem cell pool size. The journal of physiological sciences : JPS. 2023. 73. 1. 19-19
  • Seiji Hitoshi, Chitra D Mandyam, Ashok K Shetty. Editorial: Advances in adult neurogenesis. Frontiers in neuroscience. 2023. 17. 1307844-1307844
  • Asmaa Abdullah, Yoshitaka Hayashi, Naoko Morimura, Akhilesh Kumar, Kazuhiro Ikenaka, Akira Togayachi, Hisashi Narimatsu, Seiji Hitoshi. Fut9 Deficiency Causes Abnormal Neural Development in the Mouse Cerebral Cortex and Retina. Neurochemical Research. 2022. 47. 9. 2793-2804
  • Seiya Oura, Taichi Noda, Naoko Morimura, Seiji Hitoshi, Hiroshi Nishimasu, Yoshitaka Nagai, Osamu Nureki, Masahito Ikawa. Precise CAG repeat contraction in a Huntington's Disease mouse model is enabled by gene editing with SpCas9-NG. Communications Biology. 2021. 4. 1. 771-771
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MISC (48):
  • 林義剛, 郷康広, 中林一彦, アブドゥラ アスマ, モハマド ザキヤ, 等誠司. Glial cells missing1は脳損傷コア領域のグリア細胞分化と血管新生を誘導する. 日本神経化学会大会抄録集(Web). 2022. 65th
  • 林義剛, 等誠司. Postmortem brain study of major depressive disorders. 月刊精神科. 2022. 40. 4
  • 守村敏史, 伊藤靖, 等誠司, 遠山育夫, 依馬正次. バイオマテリアルとしてのカニクイザル不死化Bリンパ球バンクの構築. 日本獣医学会学術集会講演要旨集. 2021. 164th (CD-ROM)
  • 福家聡, 福家聡, 重吉康史, 中谷仁, 吉田沙織, 向所賢一, 窪田(坂下)美恵, 杉原洋行, 等誠司, 加藤忠史. 脳における欠失mtDNA蓄積とミトコンドリア機能障害がPolgヘテロ変異マウスの行動異常を誘導する. 日本ミトコンドリア学会年会要旨集. 2017. 17th
  • 小山 なつ, 等誠司. 慢性の痛みはどのように考えられてきたのか? : 慢性の痛み -何によって生み出されているのか?. 医学のあゆみ. 2017. 260. 2. 131-134
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Books (1):
  • Culturing adult neural stem cells: Application to the study of neurodegenerative and neuropsychiatric pathology in Neurogenesis in the adult brain 2 Clinical implications
    Springer 2011 ISBN:4431539441
Lectures and oral presentations  (13):
  • Glioma stem cells as a new therapeutic target.
    (2020)
  • Klf4 and 5 regulate the long-lasting neural stem cell population.
    (The 6th International Conference on Biology and Pathobiology of KLF/Sp Transcription Factors 2018)
  • Revealing the potential of postnatal neural stem cells.
    (2017 International Society for Neurochemistry (ISN)-European Society for Neurochemistry (ESN) 2017)
  • The Role of KLF proteins in senlf-renewal and differentiation of neural stem cells.
    (Science Research Conferences-Federation of American Society for Experimental Biology (SRC-FASEB) 2016)
  • The role of adult neural stem cell-neurogenesis in the pathogenesis of psychiatric disorders.
    (2016)
more...
Education (1):
  • 1993 - 1997 東京大学大学院 医学系研究科 第二臨床医学専攻
Professional career (1):
  • MD (PhD)
Work history (11):
  • 2011/12 - 現在 Shiga University of Medical Science
  • 2007/04 - 2011/11 National Institute for Physiological Sciences Department of Molecular Physiology
  • 2004/04 - 2007/03 National Institute for Physiological Sciences Department of Molecular Physiology
  • 2003/09 - 2004/03 岡崎国立共同研究機構生理学研究所 助教授
  • 2003/04 - 2003/08 The University of Tokyo
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Association Membership(s) (10):
THE JAPANESE BIOCHEMICAL SOCIETY ,  PHYSIOLOGICAL SOCIETY OF JAPAN ,  THE JAPAN NEUROSCIENCE SOCIETY ,  THE JAPANESE SOCIETY FOR NEUROCHEMISTRY ,  JAPANESE SOCIETY OF NEUROLOGY ,  THE JANPANESE SOCIETY OF INTERNAL MEDICINE ,  International Society for Stem Cell Research ,  Asia-Pacific Society for Neurochemistry ,  International Society for Neurochemistry ,  Society for Neuroscience
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