Rchr
J-GLOBAL ID:201101093204162268   Update date: Apr. 02, 2024

Hirano Tatsuya

Hirano Tatsuya
Affiliation and department:
Homepage URL  (2): http://www.riken.jp/chromdyna/http://www.riken.jp/chromdyna/index_en.html
Research field  (2): Molecular biology ,  Cell biology
Research keywords  (8): Xenopus laevis ,  Meiosis ,  Mitosis ,  SMC proteins ,  Cohesin ,  Condensin ,  Cell cycle ,  Chromosomes
Research theme for competitive and other funds  (9):
  • 2020 - 2025 Modality of mitotic chromosomes
  • 2018 - 2023 Molecular mechanisms of condensins I and II
  • 2015 - 2020 3D architecture of mitotic chromosomes
  • 2015 - 2017 Functional analyses of condensins on chromatin templates
  • 2014 - 2017 In vivo functions of condensin complexes
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Papers (109):
  • Keishi Shintomi, Yuki Masahara-Negishi, Masami Shima, Shoji Tane, Tatsuya Hirano. Recombinant cyclin B-Cdk1-Suc1 capable of multi-site mitotic phosphorylation in vitro. PLoS One. 2024. 19. 3. e0299003
  • Makoto M. Yoshida, Kazuhisa Kinoshita, Keishi Shintomi, Yuuki Aizawa, Tatsuya Hirano. Regulation of condensin II by self-suppression and release mechanisms. Molecular Biology of the Cell. 2024. 35. 2. ar21
  • Tetsuya Yamamoto, Kazuhisa Kinoshita, Tatsuya Hirano. Elasticity control of entangled chromosomes: crosstalk between condensin complexes and nucleosomes. Biophysical journal. 2023. 122. 19. P3869-3881
  • Mingxuan Sun, Hossein Amiri, Alexander B Tong, Keishi Shintomi, Tatsuya Hirano, Carlos Bustamante, Rebecca Heald. Monitoring the compaction of single DNA molecules in Xenopus egg extract in real time. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 12. e2221309120
  • Shoji Tane, Keishi Shintomi, Kazuhisa Kinoshita, Yuko Tsubota, Makoto M Yoshida, Tomoko Nishiyama, Tatsuya Hirano. Cell cycle-specific loading of condensin I is regulated by the N-terminal tail of its kleisin subunit. eLife. 2022. 11. e84694
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MISC (28):
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Books (5):
  • 実験医学増刊号「教科書を書き換えろ! 染色体の新常識:ポリマー・相分離から疾患・老化まで」
    羊土社 2018 ISBN:9784758103749
  • 染色体と細胞核のダイナミクス
    化学同人 2013 ISBN:9784759815115
  • 実験医学特集「フレミングが夢見た染色体の核心:コンデンシン・コヒーシンの発見から16年」
    羊土社 2013 ISBN:9784758101202
  • 分子細胞生物学辞典 第2版
    東京化学同人 2008
  • 生化学辞典 第4版
    東京化学同人 2007 ISBN:9784807906703
Lectures and oral presentations  (186):
  • A tale of two condensins: molecular dissection of mitotic genome folding machines
    (RIKEN International Symposium on “Nuclear Structure and Function”, Wako, Japan. 2024)
  • Condensins and mitotic genome folding
    (Research Lecture at Nobel Forum, Karolinska Institutet, Stockholm, Sweden. 2024)
  • Mitotic chromosome assembly: what happens when DNAs remain entangled?
    (BIE International Symposium, Wako, Japan. 2024)
  • How does condensin II differ from condensin I?
    (The 4th Meeting on "Genome Modality", Karolinska Institutet, Stockholm, Sweden. 2023)
  • Mitotic genome folding by topoisomerase II and condensins
    (Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. 2023)
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Professional career (1):
  • Ph. D.
Work history (16):
  • 2018/04 - 現在 RIKEN Cluster for Pioneering Research Chief Scientist
  • 2015/04 - 2018/03 RIKEN Chief Scientist
  • 2013/04 - 2015/03 RIKEN Chief Scientist
  • 2008/04 - 2013/03 RIKEN Advanced Science Institute Chief Scientist
  • 2007/04 - 2008/03 RIKEN Discovery Research Institute Chief Scientist
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Awards (7):
  • 2019 - The Asahi Prize
  • 2017 - The commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology (Research Category)
  • 2005 - The American Association for the Advancement of Science (AAAS) Fellow
  • 2003 - ISI Highly Cited Researcher
  • 1996 - Pew Scholarship
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Association Membership(s) (2):
Member, The American Society for Cell Biology ,  Member, The Molecular Biology Society of Japan
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