Rchr
J-GLOBAL ID:201101093735172136
Update date: Oct. 04, 2024
Uchigashima Motokazu
Uchigashima Motokazu
Affiliation and department:
Research field (2):
Neuroscience - general
, Neuroanatomy and physiology
Research keywords (7):
分子イメージング
, Neurotransmission
, Synaptic cell adhesion molecules
, Endocannabinoid
, Monoamine
, Striatum
, 包括脳ネットワーク
Research theme for competitive and other funds (14):
- 2024 - 2028 内在タンパク質のターンオーバーに基づく1細胞シナプス可塑性マッピングの開発と応用
- 2023 - 2025 生きた脳組織における動的シナプトミクス解析への挑戦
- 2020 - 2025 Inducing lifelong plasticity (iPlasticity) by brain rejuvenation: elucidation and manipulation of critical period mechanisms
- 2020 - 2025 Analysis of Molecular Dynamics for Structural Spine Plasticity during the Critical Period
- 2020 - 2023 Interrogation of the spatiotemporal integration of dopaminergic signaling in striatal medium spiny neurons
- 2020 - 2022 Development of a novel method for analyzing the distribution of endogenous proteins in mammalian brain tissues
- 2020 - 2020 ドーパミンシナプスの生細胞イメージングを介したドーパミン神経伝達の理解
- 2018 - ドーパミンシナプスの構造的可塑性に関する研究
- 2012 - 2017 Molecular-anatomical research on multi-modal regulation of synaptic transmission in higher brain regions
- 2015 - 2017 Study of the molecular-anatomical basis common to neuromodulatory synapses
- 2013 - 2016 Histological study of functional molecules involved in acquirement of developmental function for eating
- 2013 - 2014 Functional morphology of dopamine synapses in the mouse striatum
- 2011 - 2012 Analysis for endocannabinoid signaling in the epileptogenic circuit
- 2008 - 2010 線条体におけるドーパミンD2受容体依存的シナプス長期抑制機構の解明
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Papers (58):
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Motokazu Uchigashima, Yasunori Hayashi, Kensuke Futai. Regulation of Presynaptic Release Machinery by Cell Adhesion Molecules. Advances in Neurobiology. 2023. 33. 333-356
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Kenjiro Hanaoka, Shimpei Iwaki, Kiyoshi Yagi, Takuya Myochin, Takayuki Ikeno, Hisashi Ohno, Eita Sasaki, Toru Komatsu, Tasuku Ueno, Motokazu Uchigashima, et al. General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process. Journal of the American Chemical Society. 2022. 144. 43. 19778-19790
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Motokazu Uchigashima, Amy Cheung, Kensuke Futai. Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction. Frontiers in Molecular Neuroscience. 2021. 14. 749164-749164
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Motokazu Uchigashima, Kohtarou Konno, Emily Demchak, Amy Cheung, Takuya Watanabe, David G Keener, Manabu Abe, Timmy Le, Kenji Sakimura, Toshikuni Sasaoka, et al. Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus. eLife. 2020. 9
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Ryoji Fukabori, Yoshio Iguchi, Shigeki Kato, Kazumi Takahashi, Satoshi Eifuku, Shingo Tsuji, Akihiro Hazama, Motokazu Uchigashima, Masahiko Watanabe, Hiroshi Mizuma, et al. Enhanced Retrieval of Taste Associative Memory by Chemogenetic Activation of Locus Coeruleus Norepinephrine Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2020. 40. 43. 8367-8385
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MISC (20):
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井口 善生, 深堀 良二, 加藤 成樹, 高橋 和巳, 永福 智志, 辻 真伍, 挾間 章博, 内ヶ島 基政, 渡辺 雅彦, 水間 広, et al. 青斑核ノルアドレナリン神経細胞の活動亢進による情動記憶の想起の促進 新規神経活動活性化ツールによる検討. 日本生理学雑誌. 2021. 83. 2. 39-39
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Fukabori, R, Iguchi, Y, Kato, S, Takahashi, K, Eifuku, S, Tsuji, S, Hazama, A, Uchigashima, M, Watanabe, M, Mizuma, H, et al. Enhanced emotional memory retrieval by chemogenetic activation of locus coeruleus norepinephrine neurons. Mendeley Data. 2019
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M. Kano, M. Narushima, M. Uchigashima, M. Watanabe, A. Aiba, M. Miyata. Requirement of mGluR1 for Experience-Dependent Remodeling of Mouse Retinogeniculate Synapses. CURRENT NEUROPHARMACOLOGY. 2014. 12. 30-31
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Lack of Molecular-Anatomical Evidence for GABAergic Influence on Axon Initial Segment of Cerebellar Purkinje Cells by the Pinceau Formation. 2012. 87. 6. 273-273
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Unique inhibitory synapse with particularly rich endocannabinoid signaling machinery on pyramidal neurons in basal amygdaloid nucleus. 2012. 87. 2. 72-72
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Professional career (1):
Work history (8):
- 2021/10 - 現在 International Research Center for Neurointelligence, The University of Tokyo Institutes for Advanced Study Affiliated Faculty
- 2019/03 - 現在 Niigata University Brain Research Institute
- 2017/04 - 2019/02 Hokkaido University
- 2016/02 - 2018/03 University of Massachusetts Medical School Brudnick Neuropsychiatric Research Institute Visiting Scholar
- 2011/04 - 2017/03 Hokkaido University Graduate School of Medicine
- 2008/04 - 2011/03 日本学術振興会特別研究員 DC1
- 2007/04 - 2011/03 Hokkaido University Graduate School of Medicine
- 2001/04 - 2007/03 Hokkaido University School of Medicine
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Awards (12):
- 2022/09 - 新潟大学 新潟大学学長賞(若手教員研究奨励)
- 2022/02 - 北海道大学医学部同窓会 フラテ研究奨励賞
- 2021/12 - 新潟大学 新潟大学優秀論文表彰
- 2021/08 - 新潟大学 新潟大学学長賞
- 2020/12 - 北海道大学医学部 エクセレントティーチャー優秀賞
- 2018/09 - 第64回日本解剖学会東北・北海道連合支部学術集会 ベストプレゼンテーション賞 孤束核・分界条床核投射系のノルアドレナリン/グルタミン酸共放出ニューロンがもたらすユニークな神経伝達の分子形態学的基盤
- 2017/02 - 北海道大学大学院医学研究科 優秀論文賞 Dopamine synapse is a neuroligin-2-mediated contact between dopaminergic presynaptic and GABAergic postsynaptic structures
- 2015/12 - 包括脳ネットワーク 若手優秀発表賞 Stratal dopamine synapses are neuroligin-2-mediated heterologous contacts between dopaminergic pre synapse and GABAergic post synapse
- 2014 - 北海道大学医学部 優秀教員賞
- 2010/02 - 第15回グリアクラブ賞 Molecular-anatomical architecture of 2-arachidonoyl-glycerol-mediated retrograde signaling in the mossy cell-recipient dentate molecular layer
- 2007/12 - 日本顕微鏡学会北海道支部 奨励賞 マウス線条体における内因性カンナビノイド 2-アラキドノイルグリセロールを介した逆行性伝達抑制の分子機構
- 2006 - 北海道大学大学院医学研究科 音羽博次奨学基金
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