Nakanishi Hideyuki

ナカニシヒデユキ | Nakanishi Hideyuki

Affiliation and department：
Job title： Assistant professor
Other affiliations (1)：

Osaka University Center for Infectious Disease Education and Research (CiDER)

Research field (1)： Clinical pharmacy

Research keywords (9)： induced pluripotent stem cell , Synthetic biology , Drug Delivery System , ドラッグデリバリーシステム , genomic integration , transposon , gene therapy , トランスポゾン , 遺伝子治療

Research theme for competitive and other funds (2)：

2019 - 2023 Optical regulation system of mRNA translation with spatiotemporal and cell-type specificity
2013 - 2016 トランスポザーゼRNAの翻訳制御による導入遺伝子を含まないiPS・分化細胞の作製

Papers (18)：

Xuan Du, Erica Yada, Yuki Terai, Takuya Takahashi, Hideyuki Nakanishi, Hiroki Tanaka, Hidetaka Akita, Keiji Itaka. Comprehensive Evaluation of Lipid Nanoparticles and Polyplex Nanomicelles for Muscle-Targeted mRNA Delivery. Pharmaceutics. 2023. 15. 9. 2291-2291
Maorui Zhang, Yuta Fukushima, Kosuke Nozaki, Hideyuki Nakanishi, Jia Deng, Noriyuki Wakabayashi, Keiji Itaka. Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA. Inflammation and Regeneration. 2023. 43. 1
Kendall Free, Hideyuki Nakanishi, Keiji Itaka. Development of Synthetic mRNAs Encoding Split Cytotoxic Proteins for Selective Cell Elimination Based on Specific Protein Detection. Pharmaceutics. 2023. 15. 1. 213
Jia Deng, Yuta Fukushima, Kosuke Nozaki, Hideyuki Nakanishi, Erica Yada, Yuki Terai, Kenji Fueki, Keiji Itaka. Anti-Inflammatory Therapy for Temporomandibular Joint Osteoarthritis Using mRNA Medicine Encoding Interleukin-1 Receptor Antagonist. Pharmaceutics. 2022. 14. 9
Hideyuki Nakanishi, Tatsuyuki Yoshii, Shinya Tsukiji, Hirohide Saito. A protocol to construct RNA-protein devices for photochemical translational regulation of synthetic mRNAs in mammalian cells. STAR Protocols. 2022. 3. 2. 101451-101451

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MISC (13)：

Hideyuki Nakanishi, Keiji Itaka. -. 2023. 93. 12. 1065-1069
Hideyuki Nakanishi. Design of mRNA drugs for cell or organ-selective translation. Gekkan Saibou. 2023. 55. 11. 876-880
Hideyuki Nakanishi, Keiji Itaka. Selective cell elimination using cytotoxic protein-coding synthetic mRNAs. ISSN 2434-0359. 2023. 41. 4. 332-333
Hideyuki Nakanishi, Keiji Itaka. mRNA drugs and mRNA vaccines. 2023. 285. 5. 340-347
Hideyuki Nakanishi. -. 2023. 115-136

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Patents (4)：

P2021-122189A
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Vector and gene introduction agent for monitoring and visualizing cell differentiation using expression of micro RNA as indicator and monitoring and visualizing method using thereof

Lectures and oral presentations (46)：

Development of novel mRNA drugs equipped with conditional translational and post-translational regulation systems.
(The 39th Annual Meeting of the Japan Society of Drug Delivery System 2023)
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(The 39th Annual Meeting of the Japan Society of Drug Delivery System 2023)
Development of extracellular signal-responsive mRNA drugs for controlled translation
(The 8th Annual Meeting of Nucleic Acids Therapeutics Society of Japan 2023)
Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA
(The 44th Annual Meeting of the Japanese Society of Inflammation and Regeneration 2023)
Selective elimination of specific protein-expressing cells by split protein-encoded synthetic mRNAs
(The 44th Annual Meeting of the Japanese Society for Biomaterials 2022)

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Professional career (3)：

博士(薬学) (京都大学大学院薬学研究科)
修士(薬学) (京都大学大学院薬学研究科)
学士(薬学) (京都大学薬学部)

Awards (10)：

2023/07 - The Japanese Society of Drug Delivery System The 15th encouragement award of the Japanese society of drug delivery system
2021/10 - Tokyo Medical and Dental University (TMDU) innovation idea contest 2021 Intracellular protein-responsive cell purification system using synthetic mRNA
2018/11 - Advanced Bioimaging Support ABiS image contest: selected work
2018/10 - 日本ジェネティクス株式会社ジェネ・グラント審査員特別賞
2016/09 - The Academy of Pharmaceutical Science and Technology, Japan Global Education Seminar Presentation Award 2016

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Association Membership(s) (6)：

JAAS , Japanese Society for Cell Synthesis Research , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 日本RNA学会 , 遺伝子・デリバリー研究会 , 日本DDS学会

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