2017 - 2020 Exploration of Parkinson disease-specific pathological background
2016 - 2018 Drug screening to improve mitochondrial functions
2015 - 2018 Analysis of lipid composition in hereditary Parkinson's Disease and the association with the pathology
2014 - 2018 Elucidation of the mechanism of mitochondrial maintenance by Parkinson's disease gene products
2014 - 2018 A study on the common pathogenesis of Parkinson's disease as a mitochondrial disease
2014 - 2016 ミトコンドリアの共生を規定する、排除と維持の監視メカニズムの解明
2014 - 2016 ミトコンドリアの共生を規定する、排除と維持の監視メカニズムの解明
2012 - 2015 in vivo live imaging for sex pheromone information presentation neural mechanism in Drosophila olfaction
2011 - 2013 晩発性パーキンソン病原因遺伝子産物タンパク質ネットワークの包括的解析
2011 - 2013 晩発性パーキンソン病原因遺伝子産物タンパク質ネットワークの包括的解析
2011 - 2012 Analysis of the molecular mechanism by which the genes for early-onset parkinson's disease regulate mitochondrial maintenance
2009 - 2011 Development of a multiphase screening method for genes responsible for age-dependent neurodegenerative disorders
2003 - 2005 常染色体劣性若年性パーキンソニズムの原因遺伝子産物Parkinの機能解析
2002 - 2004 The molecular mechanisms underlying neurodegeneration
2001 - 2002 常染色体劣性若年性パーキンソニズムの原因遺伝子産物Parkinの機能解析
Perry(ペリー)症候群の実態、病因・病態の解明と治療法開発研究
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Papers (107)：
Iseki T, Imai Y, Hattori N. Is glial dysfunction the key pathogenesis of LRRK2-linked Parkinson's disease?. Biomolecules. 2023
Toshiki Tezuka, Daisuke Taniguchi, Mariko Sano, Tomoyo Shimada, Yutaka Oji, Taiji Tsunemi, Aya Ikeda, Yuanzhe Li, Hiroyo Yoshino, Jun Ogata, et al. Pathophysiological evaluation of the LRRK2 G2385R risk variant for Parkinson's disease. NPJ Parkinson's disease. 2022. 8. 1. 97-97
Kensuke Daida, Shotaro Shimonaka, Kahori Shiba-Fukushima, Jun Ogata, Hiroyo Yoshino, Ayami Okuzumi, Taku Hatano, Yumiko Motoi, Tomoki Hirunagi, Masahisa Katsuno, et al. α-Synuclein V15A Variant in Familial Parkinson's Disease Exhibits a Weaker Lipid-Binding Property. Movement disorders : official journal of the Movement Disorder Society. 2022. 37. 10. 2075-2085
Jun-Yi Liu, Tsuyoshi Inoshita, Kahori Shiba-Fukushima, Shigeharu Yoshida, Kosuke Ogata, Yasushi Ishihama, Yuzuru Imai, Nobutaka Hattori. Ubiquitination at the lysine 27 residue of the parkin ubiquitin-like domain is suggestive of a new mechanism of parkin activation. Human molecular genetics. 2022. 31. 15. 2623-2638
Tsuyoshi Inoshita, Jun-Yi Liu, Daisuke Taniguchi, Ryota Ishii, Kahori Shiba-Fukushima, Nobutaka Hattori, Yuzuru Imai. Parkinson’s disease-associated Leucine-rich repeat kinase regulates UNC-104-dependent axonal transport of Arl8-positive vesicles in Drosophila. iScience. 2022
Altered lipid metabolism and autophagy-lysosome pathway in MPAN-deficient Drosophila
(The 1st International NBIA conference in Poland 2023)
Research on Parkinson's disease-causing genes using Drosophila models.
(The 16th Soochow Neurology Forum in Suzhou 2023)
Mitochondrial twin proteins CHCHD2 and CHCHD10 as neurodegenerative disease-associated proteins
(64th Annual Meeting of the Japanese Society of Neurology, Neuroscience Frontier Symposium 03 2023)
A novel insight into the activation mechanism of Parkin, the gene product re sponsible for juvenile Parkinson's disease
(2022)
