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J-GLOBAL ID：201101097962613632
Update date: Dec. 19, 2025
Oda Mayumi
オダ マユミ | Oda Mayumi
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Affiliation and department：
Keio University Graduate School of Medicine
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Detailed information
Job title：
Assistant professor
Research field (4)：
Gastroenterology
, Veterinary medicine
, Genomics
, Systems genomics
Research keywords (14)：
ATAC-seq
, Chromatin accessibility
, DNA methylation
, Epigenomics
, Cellular differentiation
, Epigenetics
, Development and regeneration
, Tissue-specific gene expression regulation
, Genomics
, Bioinformatics
, Stem cell biology
, Transcription factors
, early development
, Developmental reprogramming
Research theme for competitive and other funds (11)：
2023 - 2027 Elucidation of molecular mechanisms underlying the flexibility of the comprehensive maintenance system of mature cell functions.
2018 - 2022 Mechanism for cardiomyocyte-specific nuclear architecture and disease development by dynamic DNA demethylation system.
2017 - 2020 Novel molecular mechanisms for enabling the maintenance and rejuvenation of tissue stem cells
2015 - 2017 The establishment of cell maturation induction method by the gene body-centered epigenomic monitoring.
2014 - 2017 Comparison of suppression effect of myopia progression focusing on mTOR signaling, ultraviolet light, and antioxidant
2013 - 2015 Optimization of direct reprograming methods by understanding the epigenomic features of descendant cell types.
2012 - 2014 Coordinated epigenetic regulation of cell type-specific genes and chronic disease development in cardiomyocytes.
2010 - 2011 Epigenomic analysis of DNA methylation pattern in cardiomyocyte development and evaluation of stem cell differentiation methods.
2010 - 2010 心不全発症モデルラットを用いた機能恒常性と疾患の標的ゲノム領域の探索
2004 - 2006 雑種強勢のエピジェネティック分子機構
2004 - 2006 雑種強勢のエピジェネティック分子機構
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Papers (45)：
Tatsuya Kusumoto, Masaya Yotsukura, Takanori Asakura, Ho Namkoong, Takunori Ogawa, Ahmed. E. Hegab, Yuhki Nakatake, Mayumi Oda, Fumitake Saito, Hirofumi Kamata, et al. Induced lung epithelial-like cells derived by direct reprogramming rescue influenza virus-induced lung injury in mice. Biochemical and Biophysical Research Communications. 2025. 778. 152384-152384
Atsuho Morita, Makoto Ishii, Takanori Asakura, Masaya Yotsukura, Ahmed E Hegab, Tatsuya Kusumoto, Ho Namkoong, Takunori Ogawa, Yuhki Nakatake, Mayumi Oda, et al. Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells. NPJ Regenerative medicine. 2025. 10. 1. 30-30
Taro Shinozaki, Kazuhiro Togasaki, Junko Hamamoto, Akifumi Mitsuishi, Takahiro Fukushima, Kai Sugihara, Toshiki Ebisudani, Masahiko Okada, Ayaka Saito, Lisa Shigematsu, et al. Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma. Nature communications. 2025. 16. 1. 4369-4369
Takahiro Fukushima, Kazuhiro Togasaki, Junko Hamamoto, Katsura Emoto, Toshiki Ebisudani, Akifumi Mitsuishi, Kai Sugihara, Taro Shinozaki, Masahiko Okada, Ayaka Saito, et al. An organoid library unveils subtype-specific IGF-1 dependency via a YAP-AP1 axis in human small cell lung cancer. Nature cancer. 2025. 6. 5. 874-891
Ryo Igarashi, Mayumi Oda, Ryo Okada, Tomoki Yano, Sirirat Takahashi, Strahil Pastuhov, Mami Matano, Norio Masuda, Kazuhiro Togasaki, Yuki Ohta, et al. Generation of human adult hepatocyte organoids with metabolic functions. Nature. 2025. 641. 8065. 1248-1257
ｍore...
MISC (50)：
Mayumi Oda, Yoshiko Hatano, Toshiro Sato. Intestinal epithelial organoids: regeneration and maintenance of the intestinal epithelium. Current opinion in genetics & development. 2022. 76. 101977-101977
小田 真由美. ゲノムの非コード重要領域を探る : ATAC-seqが拡げるクロマチンアクセシビリティ解析の可能性. 遺伝子医学 = Gene & medicine. 2022. 12. 3. 122-127
小田真由美. The effect of cell type-specificity genetic elements and epigenetic status on cellular maturation. 日本分子生物学会年会プログラム・要旨集(Web). 2021. 44th
Oda Mayumi. Epigenetics Now and Then: Toward a New Resolution. JSBi Bioinformatics Review. 2021. 2. 1. 7-14
小田真由美, 小田真由美. 心筋細胞成熟のGene body領域エピジェネティクスとスプライシング制御. 日本分子生物学会年会プログラム・要旨集(Web). 2019. 42nd
ｍore...
Patents (4)：
軽度認知障害の検出方法
体細胞から肺胞上皮細胞への分化用試薬及びその使用
軽度認知障害の検出方法
体細胞から肺胞上皮細胞への分化用試薬及びその使用
Lectures and oral presentations (1)：
「クローン動物由来の胎盤栄養膜幹細胞」
(日本畜産学会第104回大会シンポジウム 2005)
Professional career (1)：
D. V. M., Ph. D. (The University of Tokyo)
Work history (5)：
2023/04 - 現在 Keio University Department of Integrated Medicine and Biochemistry Assistant professor
2021/04 - 2023/03 Keio University School of Medicine The Sakaguchi Laboratory - Department of Organoid Medicine Project lecturer
2018/07 - 2020/03 Keio University School of Medicine Project Lecturer
2012/07 - 2018/06 Keio University School of Medicine The Sakaguchi Laboratory - Department of Systems Medicine Instructor
2010/04 - 2012/06 Keio University School of Medicine Center for Integrated Medical Research Project Instructor
Awards (2)：
2004/08 - Society for Study of Reproduction Trainee Research Poster Competition The first place
2004/08 - Society for Study of Reproduction Lalor Foundation Travel Fellow
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