Art

J-GLOBAL ID：201102202402255910   Reference number：11A0173317

mTOR: from growth signal integration to cancer, diabetes and ageing

mTOR:成長シグナル統合から癌,糖尿病と加齢

Author (4)： ZONCU Roberto (Whitehead Inst. Biomedical Res., Massachusetts, USA) ,  EFEYAN Alejo (Whitehead Inst. Biomedical Res., Massachusetts, USA) ,  SABATINI David M. (Whitehead Inst. Biomedical Res., Massachusetts, USA) ,  SABATINI David M. (Massachusetts Inst. Technol., Massachusetts, USA)
Material： Nature Reviews. Molecular Cell Biology  (Nat Rev Mol Cell Biol)
Volume： 12  Issue： 1  Page： 21-35  Publication year： Jan. 2011 
JST Material Number： W1327A  ISSN： 1471-0072  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *serine-threonine kinase ,  protein complex ,  Diabetes Mellitus ,  senile change ,  transcription factor ,  nutrient ,  growth factor ,  stress (physiology) ,  metabolic disease ,  metabolic regulation ,  starvation ,  tumor suppressor protein ,  adaptor protein ,  protein kinase ,  ether ,  macrocyclic compound ,  lactam ,  lactone ,  hemiacetal ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy ketone ,  *tumorigenesis ,  4E-BP1 ,  mTORC1 ,  TORC1 protein ,  TORC2 protein ,  insulin sensitivity ,  *Signal Transduction ,  *TOR Serine-Threonine Kinases ,  PTEN ,  Tuberous Sclerosis Complex 1 Protein ,  Tuberous Sclerosis Complex 2 Protein ,  enzyme inhibitor
Semi thesaurus term： *cellular signal transduction ,  *tumorigenesis ,  LKB1 ,  *mTOR ,  PTEN protein ,  TSC1 protein ,  TSC2 protein

JST classification (3)： Cell physiology in general  (EF02010S) ,  Enzyme in general  (EB09010D) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (1)： Sirolimus

Terms in the title (7)： mTOR ,  成長 ,  シグナル ,  統合 ,  癌 ,  糖尿病 ,  加齢