Art

J-GLOBAL ID：201102202934327251   Reference number：10A1380399

Synthesis and in vitro antiprotozoal activities of water-soluble, inexpensive phenothiazinium chlorides

水溶性で費用のかからないフェノチアジニウムクロリドの合成とin vitro抗原虫活性

Author (9)： LU Yue-ting (Key Lab. of Organic Synthesis of Jiangsu Province, Soochow Univ., 199 Ren’Ai Road, Suzhou 215123, CHN) ,  ARAI Chika (Inst. of Medicinal Chemistry, Hoshi Univ., 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JPN) ,  GE Jian-feng (Key Lab. of Organic Synthesis of Jiangsu Province, Soochow Univ., 199 Ren’Ai Road, Suzhou 215123, CHN) ,  REN Wu-sheng (Key Lab. of Organic Synthesis of Jiangsu Province, Soochow Univ., 199 Ren’Ai Road, Suzhou 215123, CHN) ,  KAISER Marcel (Swiss Tropical and Public Health Inst., Socinstrasse 57, CH-4002 Basel, CHE) ,  WITTLIN Sergio (Swiss Tropical and Public Health Inst., Socinstrasse 57, CH-4002 Basel, CHE) ,  BRUN Reto (Swiss Tropical and Public Health Inst., Socinstrasse 57, CH-4002 Basel, CHE) ,  LU Jian-mei (Key Lab. of Organic Synthesis of Jiangsu Province, Soochow Univ., 199 Ren’Ai Road, Suzhou 215123, CHN) ,  IHARA Masataka (Inst. of Medicinal Chemistry, Hoshi Univ., 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, JPN)
Material： Dyes and Pigments  (Dyes Pigments)
Volume： 89  Issue： 1  Page： 44-48  Publication year： Apr. 2011 
JST Material Number： D0966B  ISSN： 0143-7208  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： nitrogen heterocyclic compound ,  sulfur heterocyclic compound ,  anthelmintic ,  insecticide ,  endemic disease ,  derivatization ,  polynuclear aromatic compound ,  *chloride ,  protozoan infection ,  *antiprotozoan agent ,  water solubility ,  Plasmodium falciparum ,  Trypanosoma cruzi ,  Trypanosoma brucei ,  *in vitro experiment ,  toxicity test ,  concentration (ratio) ,  myoblast ,  cultured cell ,  cytotoxicity ,  *Phenothiazines ,  Leishmania donovani ,  L6 cell ,  Leishmania ,  Trypanosoma brucei rhodesiense ,  50% inhibitory concentration ,  microorganism ,  protozoa ,  Sporozoa ,  Mastigophora ,  Zoomastigophora
Semi thesaurus term： Leishmania ,  Tropical disease ,  *phenothiazinium chloride ,  Protozoiasis ,  antiprotozoal agent ,  Trypanosoma brucei rhodesiense ,  in vitro assay ,  IC50

JST classification (3)： Basic research of antiprotozoan drugs and anthelmintics  (GW17080G) ,  Nitrogen heterocycles in general  (CF07040G) ,  Sulfur heterocycles in general  (CF07030V)

Substance index (5)： 3,7-Bis(pyrrolidine-1-yl)phenothiazine-5-ium・chloride ,  3,7-Bispiperidinophenothiazine-5-ium・chloride ,  3,7-Bis[methyl(phenyl)amino]phenothiazine-5-ium・chloride ,  3,7-Bis[methyl(benzyl)amino]phenothiazine-5-ium・chloride ,  3,7-Bis[dibenzylamino]phenothiazine-5-ium・chloride

Terms in the title (3)： 水溶性 ,  費用 ,  抗原虫活性