Art

J-GLOBAL ID：201102218168824675   Reference number：11A0598597

Progression of Alcoholic and Non-alcoholic Steatohepatitis: Common Metabolic Aspects of Innate Immune System and Oxidative Stress

アルコール性および非アルコール性脂肪性肝炎の進行:自然免疫系および酸化的ストレスの共通の代謝的側面

Author (5)： SAKAGUCHI Shuhei (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  TAKAHASHI Shougo (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  SASAKI Takamitsu (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  KUMAGAI Takeshi (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  NAGATA Kiyoshi (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.)
Material： Drug Metabolism and Pharmacokinetics  (Drug Metab Pharmacokinet)
Volume： 26  Issue： 1  Page： 30-46 (J-STAGE)  Publication year： 2011 
JST Material Number： X0758A  ISSN： 1347-4367  Document type： Article
Article type： 文献レビュー  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： CYP2E1 ,...

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JST classification (2)： Basic biopharmacy  (GY01021U) ,  Basic medicine on digestive system  (GH01020E)

Substance index (2)： Acetaldehyde ,  Ethanol

Reference (82)：

• 1) McClain, C. J., Song, Z., Barve, S. S., Hill, D. B. and Deaciuc, I.: Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease. Am. J. Physiol. Gastrointest. Liver Physiol., 287: G497–G502 (2004).
• 2) Bode, C. and Bode, J. C.: Activation of the innate immune system and alcoholic live disease: Effects of ethanol per se or enhanced intestinal translocation of bacterial toxins induced by ethanol? Alcohol. Clin. Exp. Res., 29: 166S–171S (2005).
• 3) Mandrekar, P.: Signaling mechanisms in alcoholic liver injury: Role of transcription factor, kinase and heat shock proteins. World J. Gastroenterol., 13: 4979–4985 (2007).
• 4) Vidali, M., Hietala, J., Occhino, G., Ivaldi, A., Sutti, S., Niemelä, O. and Albano, E.: Immune responses against oxidative stress-derived antigens are associated with increased circulating tumor necrosis factor-α in heavy drinkers. Free Radic. Biol. Med., 45: 306–311 (2008).
• 5) Mandrekar, P. and Szabo, G.: Signalling pathways in alcohol-induced liver inflammation. J. Hepatol., 50: 1258–1266 (2009).

Terms in the title (5)： アルコール ,  非アルコール性脂肪性肝炎 ,  免疫系 ,  酸化的ストレス ,  代謝