Art

J-GLOBAL ID：201102219893437438   Reference number：11A0611892

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

ロサルタンは腫瘍においてコラーゲンI合成を阻害し,ナノセラピューティクスの分布と効果を改善する

Author (8)： DIOP-FRIMPONG Benjamin (Harvard Medical School, MA) ,  DIOP-FRIMPONG Benjamin (Harvard-Massachusetts Inst. Technol. Div. Health Sci. and Technol., MA) ,  DIOP-FRIMPONG Benjamin (Harvard Univ., MA) ,  CHAUHAN Vikash P. (Harvard Medical School, MA) ,  CHAUHAN Vikash P. (Harvard Univ., MA) ,  KRANE Stephen (Harvard Medical School, MA) ,  BOUCHER Yves (Harvard Medical School, MA) ,  JAIN Rakesh K. (Harvard Medical School, MA)
Material： Proceedings of the National Academy of Sciences of the United States of America  (PNAS)
Volume： 108  Issue： 7  Page： 2909-2914  Publication year： Feb. 15, 2011 
JST Material Number： D0387A  ISSN： 0027-8424  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Thesaurus term： *hypotensive drug ,  *Collagen ,  *protein synthesis ,  effect ,  *tumor ,  dependence ,  Simplexvirus ,  liposome ,  anthracycline antibiotics ,  antibiotics ,  alcohol ,  nitrogen heterocyclic compound ,  aromatic compound ,  organochlorine compound ,  amino sugar ,  quinone ,  glycoside (except carbohydrate) ,  polyphenol ,  deoxysugar ,  pyranoside ,  phenol ether ,  polynuclear aromatic compound ,  hydroxy ketone ,  polyol ,  *Collagen Type I ,  *Scleroproteins ,  *animal protein ,  microorganism ,  Herpesviridae ,  animal virus ,  thin film ,  bilayer ,  lipid membrane ,  layer ,  multilayer (molecule) ,  multilayer ,  lipid bilayer membrane ,  antitumor drug ,  drug ,  antineoplastic antibiotics ,  antibacterial drug ,  antimicrobial drug
Semi thesaurus term： clinical effects ,  dosage dependence ,  PEG-coated liposome

JST classification (2)： Experimental treatment for tumors  (GE02040Y) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Substance index (2)： Losartan ,  Doxorubicin

Terms in the title (5)： ロサルタン ,  腫瘍 ,  コラーゲンI ,  阻害 ,  分布