Art

J-GLOBAL ID：201102223143715646   Reference number：11A0104965

Concise and modular synthesis of regioisomeric haptens for the production of high-affinity and stereoselective antibodies to the strobilurin azoxystrobin

ストロビルリン系アゾキシストロビンに対する高親和性および立体選択的抗体創製のための位置特異性ハプテンの簡潔かつモジュラー合成

Author (5)： PARRA Javier (Dep. of Biotechnology, IATA-CSIC, Agusti Escardino 7, 46980 Paterna, Valencia, ESP) ,  MERCADER Josep V. (Dep. of Biotechnology, IATA-CSIC, Agusti Escardino 7, 46980 Paterna, Valencia, ESP) ,  AGULLO Consuelo (Dep. of Organic Chemistry, Univ. de Valencia, Doctor Moliner 50, 46100 Burjassot, Valencia, ESP) ,  ABAD-FUENTES Antonio (Dep. of Biotechnology, IATA-CSIC, Agusti Escardino 7, 46980 Paterna, Valencia, ESP) ,  ABAD-SOMOVILLA Antonio (Dep. of Organic Chemistry, Univ. de Valencia, Doctor Moliner 50, 46100 Burjassot, Valencia, ESP)
Material： Tetrahedron  (Tetrahedron Symposia-in-Print)
Volume： 67  Issue： 3  Page： 624-635  Publication year： Jan. 21, 2011 
JST Material Number： E0234A  ISSN： 0040-4020  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *hapten ,  stereoselectivity ,  binding site ,  *Sonogashira reaction ,  *Suzuki reaction ,  *immuno cross reactivity ,  chemical synthesis ,  *antiserum ,  *polyclonal antibody ,  *nitrogen heterocyclic compound ,  phenol ether ,  regiospecific reaction ,  immunoassay ,  *Pyrimidines ,  *reaction ,  *immune response ,  bioassay
Semi thesaurus term： immunoassay ,  *Pyrimidines

JST classification (2)： Production and application of antigens,antibodies,complements  (ED04030W) ,  Pyrimidines  (CF07103W)

Substance index (17)： 2-Hydroxybenzonitrile ,  Azoxystrobin ,  (E)-3-Methoxy-2-[2-[6-(2-cyanophenoxy)-4-pyrimidinyloxy]-5-(5-carboxypentyl)phenyl]acrylic acid 1-methyl ester ,  (E)-3-Methoxy-2-[2-[2-(5-carboxypentyl)-6-(2-cyanophenoxy)-4-pyrimidinyloxy]phenyl]acrylic acid 1-methyl ester ,  (E)-3-Methoxy-2-[2-[6-[4-(5-carboxypentyl)-2-cyanophenoxy]-4-pyrimidinyloxy]phenyl]acrylic acid 1-methyl ester ,  (E)-3-(5-Carboxypentoxy)-2-[2-[6-(2-cyanophenoxy)-4-pyrimidinyloxy]phenyl]acrylic acid 1-methyl ester ,  2-(Benzyloxy)-5-bromophenylboronic acid ,  (E)-3-Methoxy-2-[2-hydroxy-5-[5-(tert-butoxycarbonyl)pentyl]phenyl]acrylic acid methyl ester ,  (E)-3-Methoxy-2-[2-(6-chloro-4-pyrimidinyloxy)-5-[5-(tert-butoxycarbonyl)pentyl]phenyl]acrylic acid methyl ester ,  (E)-3-Methoxy-2-[2-[6-(2-cyanophenoxy)-4-pyrimidinyloxy]-5-[5-(tert-butoxycarbonyl)pentyl]phenyl]acrylic acid methyl ester ,  6-(4,6-Dichloro-2-pyrimidinyl)-5-hexynoic acid tert-butyl ester ,  (E)-3-Methoxy-2-(2-hydroxyphenyl)acrylic acid methyl ester ,  (E)-3-Methoxy-2-[2-[2-[5-(tert-butoxycarbonyl)pentyl]-6-(2-cyanophenoxy)-4-pyrimidinyloxy]phenyl]acrylic acid methyl ester ,  6-(3-Cyano-4-hydroxyphenyl)hexanoic acid tert-butyl ester ,  (E)-3-[5-(tert-Butoxycarbonyl)pentoxy]-2-(2-hydroxyphenyl)acrylic acid methyl ester ,  [2-[6-(2-Cyanophenoxy)-4-pyrimidinyloxy]phenyl]acetic acid methyl ester ,  (E)-2-(6-Phenoxy-4-pyrimidinyloxy)-3-methoxyacrylic acid methyl ester

Terms in the title (8)： ストロビルリン ,  アゾキシストロビン ,  親和性 ,  立体 ,  抗体 ,  創製 ,  位置特異性 ,  ハプテン