Art

J-GLOBAL ID：201102223352923434   Reference number：11A0759423

Effectiveness of A Novel Immunomodulator, FTY720 (Fingolimod), on Atopic Dermatitis

アトピー性皮膚炎に対する新規免疫調節薬FTY720(フィンゴリモド)の有用性

Author (8)： TSUJI TAKUMI (摂南大 薬) ,  KATO YUSEI (摂南大 薬) ,  MITSUI KANA (摂南大 薬) ,  NAKAYA FUMI (摂南大 薬) ,  WATANABE KOJI (摂南大 薬) ,  YOSHIDA YUYA (摂南大 薬) ,  KONO TAKEYUKI (摂南大 薬) ,  FUJITA TETSURO (生産開発科研)
Material： 薬理と臨床  (Clinical Pharmacology and Therapy)
Volume： 21  Issue： 2  Page： 75-79  Publication year： Mar. 25, 2011 
JST Material Number： L1701A  ISSN： 0917-3994  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： Mus musculus ,...

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JST classification (2)： Immunologic diseases,allergic diseases in general.  (GD04010C) ,  Basic research of immunotherapeutic agents and blood preparations  (GW22010D)

Substance index (1)： Fingolimod

Reference (10)：

• T. Fujita, K. Inoue, S. Yamamoto, T. Ikumoto, S. Sasaki, R. Toyama, K. Chiba, Y. Hoshino & T. Okumoto: Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sin-clairii metabolite. J. Antibiot., 47: 208-215, 1994
• K. Adachi, T. Kohara, N. Nakao, M. Arita, K. Chiba, T. Mishina, S. Sasaki & T. Fujita: Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1, 3-propanediols: Discovery of a novel immunosuppressant, FTY720. Bioorg. Med. Chem. Lett., 5: 853-856, 1995
• M. Kiuchi, K. Adachi, T. Kohara, M. Minoguchi, T. Hanano, Y. Aoki, T. Mishina, M. Arita, N. Nakao, M. Ohtsuki, Y. Hoshino, K. Teshima, K. Chiba, S. Sasaki & T. Fujita: Synthesis and immunosup pressive activity of 2-substituted 2-aminopropane-1, 3-diols and 2-aminoethanols. J. Med. Chem., 43: 2946-2961, 2000
• 千葉健治: スフィンゴシン1--リン酸受容体アゴニストによるリンパ球動態調節. 医学のあゆみ (医歯薬出版株式会社), 11, 995~999, 2005
• K. Chiba, Y. Yanagawa, Y. Masubuchi, H. Kataoka, T. Kawaguchi, M. Ohtsuki & Y. Hoshino: FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of cir culating mature lymphocytes by acceleration of lymphocyte homing. J. Immunol., 160: 5037-5044, 1998

Terms in the title (5)： アトピー性皮膚炎 ,  免疫調節薬 ,  FTY720 ,  フィンゴリモド ,  有用性