Art

J-GLOBAL ID：201102223473682760   Reference number：11A0966451

An accurate quantitative LC/ESI-MS/MS method for sirolimus in human whole blood

ヒト全血中のシロリムスの正確なLC/ESI-MS/MSの定量法

Author (11)： MANO Nariyasu (Dep. of Pharmaceutical Sciences, Tohoku Univ. Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JPN) ,  MANO Nariyasu (Dep. of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Tohoku Univ., 1-1 Seiryo-machi, Aoba-ku ...) ,  SATO Mayumi (Dep. of Pharmaceutical Sciences, Tohoku Univ. Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JPN) ,  NOZAWA Marina (Dep. of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Tohoku Univ., 1-1 Seiryo-machi, Aoba-ku ...) ,  MATSUMOTO Yotaro (Dep. of Pharmaceutical Sciences, Tohoku Univ. Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JPN) ,  MORI Masaru (Dep. of Pharmaceutical Sciences, Tohoku Univ. Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JPN) ,  YAMAGUCHI Hiroaki (Dep. of Pharmaceutical Sciences, Tohoku Univ. Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JPN) ,  YAMAGUCHI Hiroaki (Dep. of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Tohoku Univ., 1-1 Seiryo-machi, Aoba-ku ...) ,  GOTO Junichi (Dep. of Pharmaceutical Sciences, Tohoku Univ. Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JPN) ,  SHIMADA Miki (Dep. of Pharmaceutical Sciences, Tohoku Univ. Hospital, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, JPN) ,  SHIMADA Miki (Dep. of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Tohoku Univ., 1-1 Seiryo-machi, Aoba-ku ...)
Material： Journal of Chromatography B  (Journal of Chromatography B. Analytical Technologies in the Biomedical and Life Sciences)
Volume： 879  Issue： 13-14  Page： 987-992  Publication year： Apr. 15, 2011 
JST Material Number： W0571A  ISSN： 1570-0232  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *human(primates) ,  *blood concentration ,  *hemiacetal ,  drug distribution ,  *LC-MS analysis ,  *tandem mass spectrometry ,  Electrospray Ionization Mass Spectrometry ,  *quantitative analysis(analytical chemistry) ,  therapeutic drug monitoring ,  immunosuppressant ,  recovery rate ,  pretreatment ,  immunoassay ,  comparative test ,  immuno cross reactivity ,  matrix effect ,  ether ,  macrocyclic compound ,  lactam ,  lactone ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy ketone ,  enzyme inhibitor
Semi thesaurus term： *LC/MS/MS

JST classification (2)： Miscellaneous analytical methods of organic compounds  (CC08034J) ,  Basic biopharmacy  (GY01021U)

Substance index (1)： Rapamycin

Terms in the title (4)： ヒト ,  全血 ,  シロリムス ,  定量法