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J-GLOBAL ID：201102234445794679   Reference number：11A0527576

Diazepam Enhances Production of Diazepam-Binding Inhibitor (DBI), a Negative Saliva Secretion Regulator, Localized in Rat Salivary Gland

ジアゼパムはラット唾液腺に局在する負の唾液分泌調節因子,ジアゼパム結合阻害剤(DBI)の産生を増強する

Author (8)： TSUKAGOSHI Eri (Dep. of Pharmacology, Tokyo Dental Coll., JPN) ,  KAWAGUCHI Mitsuru (Dep. of Pharmacology, Tokyo Dental Coll., JPN) ,  SHINOMIYA Takashi (Dep. of Pharmacology, Tokyo Dental Coll., JPN) ,  YOSHIKAWA Masanobu (Dep. of Pharmacology, Tokyo Dental Coll., JPN) ,  YOSHIKAWA Masanobu (Dep. of Clinical Pharmacology, Tokai Univ. School of Medicine, JPN) ,  KAWANO Toshihiko (Dep. of Pharmacology, Tokyo Dental Coll., JPN) ,  OKUBO Migiwa (Dep. of Pharmacology, Tokyo Dental Coll., JPN) ,  SAWAKI Kohei (Dep. of Pharmacology, Tokyo Dental Coll., JPN)
Material： Journal of Pharmacological Sciences  (J Pharmacol Sci)
Volume： 115  Issue： 2  Page： 221-229 (J-STAGE)  Publication year： 2011 
JST Material Number： G0813A  ISSN： 1347-8613  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *benzodiazepine antianxiety drug ,...
Semi thesaurus term： mRNA expression ,...

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JST classification (4)： Basic research of psychotropic drugs  (GW03100Y) ,  Proteins and peptides in general  (EB03010N) ,  Bioactive peptides  (EB08100U) ,  Mouth(=oral cavity),esophagus  (EJ06020R)

Substance index (1)： Diazepam

Reference (32)：

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• 2 Kawaguchi M, Ouchi K, Ohse S, Baba Y. In vivo and in vitro studies on receptive mechanisms for benzodiazepines in rat parotid gland. Dent Jpn. 1995;32:38–40.
• 3 Kawaguchi M, Yamagishi H. Coupling of benzodiazepine and GABA(A) receptors in the salivary glands is a factor of drug-induced xerostomia. Int Acad Biomed Drug Res. 1996;11:291–296.
• 4 Yamagishi H, Kawaguchi M. Characterization of central- and peripheral-type benzodiazepine receptors in rat salivary glands. Biochem Pharmacol. 1998;55:209–214.
• 5 Yamagishi H, Watanabe M, Yazaki K, Sawaki K, Kawaguchi M. Pharmacological characterization of an 18-kDa protein associated with the peripheral-type benzodiazepine receptor in salivary glands. Jpn J Pharmacol. 2000;82:110–115.

Terms in the title (7)： ジアゼパム ,  ラット ,  唾液腺 ,  唾液分泌 ,  調節因子 ,  ジアゼパム結合阻害剤 ,  増強