Art

J-GLOBAL ID：201102237721707202   Reference number：11A0110997

Selective inhibition of BET bromodomains

BETブロモドメインの選択的阻害

Author (25)： FILIPPAKOPOULOS Panagis (Univ. Oxford, Oxford, GBR) ,  PICAUD Sarah (Univ. Oxford, Oxford, GBR) ,  FEDOROV Oleg (Univ. Oxford, Oxford, GBR) ,  KEATES Tracey (Univ. Oxford, Oxford, GBR) ,  FELLETAR Ildiko (Univ. Oxford, Oxford, GBR) ,  PHILPOTT Martin (Univ. Oxford, Oxford, GBR) ,  HEIGHTMAN Tom D. (Univ. Oxford, Oxford, GBR) ,  KNAPP Stefan (Univ. Oxford, Oxford, GBR) ,  QI Jun (Harvard Medical School, Massachusetts, USA) ,  SMITH William B. (Harvard Medical School, Massachusetts, USA) ,  MORSE Elizabeth M. (Harvard Medical School, Massachusetts, USA) ,  MCKEOWN Michael R. (Harvard Medical School, Massachusetts, USA) ,  WEST Nathan (Harvard Medical School, Massachusetts, USA) ,  BRADNER James E. (Harvard Medical School, Massachusetts, USA) ,  SHEN Yao (Univ. Notre Dame, Indiana, USA) ,  WIEST Olaf (Univ. Notre Dame, Indiana, USA) ,  HICKMAN Tyler T. (Harvard Medical School, Massachusetts, USA) ,  CAMERON Michael J. (Harvard Medical School, Massachusetts, USA) ,  SCHWARTZ Brian (Harvard Medical School, Massachusetts, USA) ,  FRENCH Christopher A. (Harvard Medical School, Massachusetts, USA) ,  MUNRO Shonagh (Univ. Oxford, Oxford, GBR) ,  LA THANGUE Nicholas (Univ. Oxford, Oxford, GBR) ,  WANG Yuchuan (Harvard Medical School, Massachusetts, USA) ,  CHRISTIE Amanda L. (Harvard Medical School, Massachusetts, USA) ,  KUNG Andrew L. (Harvard Medical School, Massachusetts, USA)
Material： Nature (London)  (Nature (Lond))
Volume： 468  Issue： 7327  Page： 1067-1073  Publication year： Dec. 23, 2010 
JST Material Number： D0193B  ISSN： 0028-0836  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： genetics ,  *protein ,  *binding site ,  crystal structure ,  tertiary structure ,  squamous cell carcinoma ,  oncoprotein ,  X-ray diffraction ,  fusion protein ,  chromatin ,  human(primates) ,  antitumor drug ,  translocation(genetics) ,  enzyme inhibitor

JST classification (2)： Gene expression  (EC02040Q) ,  Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

Substance index (2)： JQ-1 ,  (-)-JQ-1

Terms in the title (2)： ブロモドメイン ,  阻害