Art

J-GLOBAL ID：201102245450269800   Reference number：11A0535879

Randomized Phase II Study Comparing Dose Escalated Weekly Paclitaxel vs. Standard Dose Weekly Paclitaxel for Patients with Previously Treated Advanced Gastric Cancer

既治療進行胃癌患者に対するパクリタキセル毎週用量増加対パクリタキセル毎週標準用量を比較するランダム化第II相試験

Author (13)： SHITARA Kohei (Aichi Cancer Center Hospital, Nagoya) ,  OZE Isao (Aichi Cancer Center Res. Inst., Nagoya) ,  MIZOTA Ayako (Aichi Cancer Center Hospital, Nagoya) ,  KONDO Chihiro (Aichi Cancer Center Hospital, Nagoya) ,  NOMURA Motoo (Aichi Cancer Center Hospital, Nagoya) ,  YOKOTA Tomoya (Aichi Cancer Center Hospital, Nagoya) ,  TAKAHARI Daisuke (Aichi Cancer Center Hospital, Nagoya) ,  URA Takashi (Aichi Cancer Center Hospital, Nagoya) ,  YUKI Satoshi (Hokkaido Univ. Graduate School of Medicine, Hokkaido) ,  KOMATSU Yoshito (Hokkaido Univ. Graduate School of Medicine, Hokkaido) ,  KOMATSU Yoshito (Hokkaido Univ. Hospital Cancer Center, Hokkaido, JPN) ,  MATSUO Keitaro (Aichi Cancer Center Res. Inst., Nagoya) ,  MURO Kei (Aichi Cancer Center Hospital, Nagoya)
Material： Japanese Journal of Clinical Oncology  (JJCO)
Volume： 41  Issue： 2  Page： 287-290  Publication year： Feb. 2011 
JST Material Number： W2222A  ISSN： 0368-2811  Document type： Article
Article type： 解説  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Thesaurus term： *stomach tumor ,...
Semi thesaurus term： RCT ,...

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JST classification (2)： Tumors(=neoplasms)of digestive system  (GH04000D) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C)

Substance index (1)： Paclitaxel

Reference (16)：

• Hironaka S, Zenda S, Boku N, Fukutomi A, Yoshino T, Onozawa Y. Weekly paclitaxel as second-line chemotherapy for advanced or recurrent gastric cancer. Gastric Cancer 2006; 9: 14-8.
• Takiuchi H, Fukuda H, Boku N, Shimada Y, Nasu J, Hamamoto Y, et al. Randomized phase II study of best-available 5-fluorouracil (5-FU) versus weekly paclitaxel in gastric cancer (GC) with peritoneal metastasis (PM) refractory to 5-FU-containing regimens (JCOG0407). J Clin Oncol 2010; 28: 15S (suppl; abstr 4052).
• Sparano JA, Wang M, Martino S, Jones V, Perez EA, Saphner T, et al. Weekly paclitaxel in the adjuvant treatment of breast cancer. N Engl J Med 2008; 358: 1663-71.
• Katsumata N, Yasuda M, Takahashi F, Isonishi S, Jobo T, Aoki D, et al. Dose-dense paclitaxel once a week in combination with carboplatin every 3 weeks for advanced ovarian cancer: a phase 3, open-label, randomised controlled trial. Lancet 2009; 374: 1331-8.
• Kato K, Tahara M, Hironaka S, Muro K, Takiuchi H, Hamamoto Y, et al. A phase II study of paclitaxel by weekly 1-h infusion for advanced or recurrent esophageal cancer in patients who had previously received platinum-based chemotherapy. Cancer Chemother Pharmacol 2010 [Epub ahead of print].

Terms in the title (7)： 治療 ,  進行胃癌 ,  患者 ,  パクリタキセル ,  用量 ,  標準 ,  第II相試験