Art

J-GLOBAL ID：201102246666826727   Reference number：11A1522103

Urinary 2-hydroxy-5-oxoproline, the lactam form of α-ketoglutaramate, is markedly increased in urea cycle disorders

尿のα-ケトグルタルアミド酸のラクタム形である2-ヒドロキシ-5-オキソプロリンは,尿素サイクル異常症において著しく増加する

Author (5)： KUHARA Tomiko (Kanazawa Medical Univ., Dep. of Biochemistry, Div. of Human Genetics, Medical Res. Inst., Uchinada, Kahoku-gun, 920 ...) ,  INOUE Yoshito (Kanazawa Medical Univ., Dep. of Biochemistry, Div. of Human Genetics, Medical Res. Inst., Uchinada, Kahoku-gun, 920 ...) ,  OHSE Morimasa (Kanazawa Medical Univ., Dep. of Biochemistry, Div. of Human Genetics, Medical Res. Inst., Uchinada, Kahoku-gun, 920 ...) ,  KRASNIKOV Boris F. (New York Medical Coll., Dep. of Biochemistry and Molecular Biology, 10595, Valhalla, NY, USA) ,  COOPER Arthur J. L. (New York Medical Coll., Dep. of Biochemistry and Molecular Biology, 10595, Valhalla, NY, USA)
Material： Analytical & Bioanalytical Chemistry  (Anal Bioanal Chem)
Volume： 400  Issue： 7  Page： 1843-1851  Publication year： Jun. 2011 
JST Material Number： E0425B  ISSN： 1618-2642  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Thesaurus term： lactam ,  *metabolic disease ,  *GC-MS analysis ,  Hyperammonemia ,  kidney disease ,  Urine ,  aliphatic ketone ,  aliphatic carboxylic acid ,  keto acid ,  dicarboxylic acid ,  excreta ,  excretory substance
Semi thesaurus term： Lysinuria ,  *Disorders of urea cycle metabolism

JST classification (2)： Miscellaneous analytical methods of organic compounds  (CC08034J) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J)

Substance index (3)： α-Ketoglutaric acid ,  2-Oxoglutaramate ,  2-Hydroxy-5-oxoproline

Reference (29)：

• Meister A, Sober HA, Tice SV, Fraser PE (1952) Transamination and associated deamidation of asparagine and glutamine. J Biol Chem 197:319-330
• Meister A (1953) Preparation and enzymatic reactions of the keto acid analogues of asparagine and glutamine. J Biol Chem 200:571-581
• Meister A, Levintow L, Greenfield RE, Abendschein PA (1955) Hydrolysis and transfer reactions catalyzed by ω-amidase preparations. J Biol Chem 215:441-460
• Cooper AJL, Meister A (1972) Isolation and properties of highly purified glutamine transaminase. Biochemistry 11:661-671
• Cooper AJL, Meister A (1974) Isolation and properties of a new glutamine transaminase from rat kidney. J Biol Chem 249:2554-2561

Terms in the title (5)： 尿 ,  酸 ,  ラクタム ,  5-オキソプロリン ,  尿素サイクル異常症