Art

J-GLOBAL ID：201102246909579723   Reference number：11A1702543

Comparison of two POLQ mutants reveals that a polymerase-inactive POLQ retains significant function in tolerance to etoposide and γ-irradiation in mouse B cells

二つのPOLQ突然変異体類の比較はポリメラーゼ不活性POLQがマウスのB細胞においてエトポシドおよびγ線照射への耐性に有意な機能を維持していることを明らかにする

Author (4)： LI Yingqian (Medical School of Nanjing Univ., Nanjing, CHN) ,  LI Yingqian (RIKEN, Yokohama, JPN) ,  GAO Xiang (Medical School of Nanjing Univ., Nanjing, CHN) ,  WANG Ji-Yang (RIKEN, Yokohama, JPN)
Material： Genes to Cells  (Genes Cells)
Volume： 16  Issue： 9  Page： 973-983  Publication year： Sep. 2011 
JST Material Number： W0935A  ISSN： 1356-9597  CODEN： GECEFL  Document type： Article
Article type： 原著論文  Country of issue： Australia (AUS)  Language： ENGLISH (EN)

Thesaurus term： *Mus musculus ,...
Semi thesaurus term： recombination ,...

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JST classification (3)： Enzyme physiology  (EJ02020P) ,  Cell physiology in general  (EF02010S) ,  Influence on animals  (EE04040K)

Substance index (1)： Etoposide

Reference (31)：

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• Boyd, J.B., Sakaguchi, K. & Harris, P.V. (1990) mus308 mutants of Drosophila exhibit hypersensitivity to DNA cross-linking agents and are defective in a deoxyribonuclease. Genetics 125, 813-819.
• Chan, S.H., Yu, A.M. & McVey, M. (2010) Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila. PLoS Genet. 6, e1001005.
• Di Noia, J.M. & Neuberger, M.S. (2007) Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 76, 1-22.

Terms in the title (7)： 突然変異体 ,  不活性 ,  マウス ,  B細胞 ,  エトポシド ,  γ線 ,  耐性