Art

J-GLOBAL ID：201102247019242868   Reference number：11A0809476

Depot-Specific Expression of Lipolytic Genes in Human Adipose Tissues -Association Among CES1 Expression, Triglyceride Lipase Activity and Adiposity

ヒト脂肪組織における脂肪分解遺伝子の貯蔵脂肪特異的発現-CES1発現,トリグリセリドリパーゼ活性および肥満症間の関連

Author (26)： NAGASHIMA Shuichi (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  YAGYU Hiroaki (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  TAKAHASHI Nirei (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  KURASHINA Tomoyuki (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  TAKAHASHI Manabu (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  TSUCHITA Takeshi (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  TAZOE Fumiko (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  WANG Xiao Li (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  BAYASGALAN Tumenbayar (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  SATO Naoko (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  OKADA Kenta (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  NAGASAKA Shoichiro (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.) ,  GOTOH Takaya (Div. of Human Genetics, Center for Community Medicine, Jichi Medical Univ.) ,  KOJIMA Masayuki (Dep. of Surgery, Jichi Medical Univ.) ,  HYODO Masanobu (Dep. of Surgery, Jichi Medical Univ.) ,  HORIE Hisanaga (Dep. of Surgery, Jichi Medical Univ.) ,  HOSOYA Yoshinori (Dep. of Surgery, Jichi Medical Univ.) ,  OKADA Masaki (Dep. of Surgery, Jichi Medical Univ.) ,  YASUDA Yoshikazu (Dep. of Surgery, Jichi Medical Univ.) ,  FUJIWARA Hiroyuki (Dep. of Obstetrics and Gynecology, Jichi Medical Univ.) ,  OHWADA Michitaka (Dep. of Obstetrics and Gynecology, Jichi Medical Univ.) ,  IWAMOTO Sadahiko (Div. of Human Genetics, Center for Community Medicine, Jichi Medical Univ.) ,  SUZUKI Mitsuaki (Dep. of Obstetrics and Gynecology, Jichi Medical Univ.) ,  NAGAI Hideo (Dep. of Surgery, Jichi Medical Univ.) ,  NAGAI Hideo (Dep. of Surgery, Ibaraki Prefectural Central Hospital.) ,  ISHIBASHI Shun (Div. of Endocrinology and Metabolism, Diabetes Center, Dep. of Medicine, Jichi Medical Univ.)
Material： Journal of Atherosclerosis and Thrombosis (Web)  (J Atheroscler Thromb (Web))
Volume： 18  Issue： 3  Page： 190-199 (J-STAGE)  Publication year： 2011 
JST Material Number： U0153A  ISSN： 1880-3873  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： mRNA expression ,...

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JST classification (3)： Gene expression  (EC02040Q) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Enzyme in general  (EB09010D)

Reference (50)：

• 1) Boden G: Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes, 1997; 46: 3-10
• 2) Furuhashi M, Hotamisligil GS: Fatty acidbinding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov, 2008; 7: 489-503
• 3) Zechner R, Strauss JG, Haemmerle G, Lass A, Zimmermann R: Lipolysis: pathway under construction. Curr Opin Lipidol, 2005; 16: 333-340
• 4) Arner P, Langin D: The role of neutral lipases in human adipose tissue lipolysis. Curr Opin Lipidol, 2007; 18: 246-250
• 5) Holm C: Molecular mechanisms regulating hormonesen-sitive lipase and lipolysis. Biochem Soc Trans, 2003; 31: 1120-1124

Terms in the title (10)： ヒト ,  脂肪組織 ,  脂肪分解 ,  遺伝子 ,  貯蔵 ,  脂肪 ,  発現 ,  トリグリセリドリパーゼ ,  活性 ,  肥満症