Art

J-GLOBAL ID：201102248868852854   Reference number：11A1769500

Duration of effective bioactivity eluted from antibiotic-impregnated cement spacer in treatment of infected knee

膝関節感染症治療におけるセメントスペーサーの抗菌薬徐放期間

Author (6)： ASADA SHIGEKI (近畿大学医学部整形外科学教室) ,  AKAGI MASAO (近畿大学医学部整形外科学教室) ,  MATSUSHITA TETSUTAKA (近畿大学医学部整形外科学教室) ,  MORI SHIGESHI (近畿大学医学部整形外科学教室) ,  HASHIMOTO KAZUYOSHI (近畿大学医学部整形外科学教室) ,  HAMANISHI CHIAKI (近畿大学医学部整形外科学教室)
Material： 中部日本整形外科災害外科学会雑誌  (中部日本整形外科災害外科学会抄録集)
Volume： 54  Issue： 5  Page： 967-968 (J-STAGE)  Publication year： 2011 
JST Material Number： Z0420B  ISSN： 0008-9443  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： human(primates) ,...
Semi thesaurus term： *cement spacer ,...

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JST classification (3)： Drug therapy(=pharmacotherapy)for musculoskeletal diseases  (GG05020D) ,  Clinical biopharmacy  (GY01022L) ,  Clinical application of antibacterial drugs  (GW17030D)

Substance index (2)： Vancomycin hydrochloride ,  Amikacin sulfate

Reference (5)：

• 1) Leone JM, Hanssen AD. Management of infection at the site of a total knee arthroplasty. J Bone Joint Surg 2005; 87(10)-A: 2335-2348.
• 2) Cui Q, Mihalko WM, Shields JS, et al. Antibiotic-impregnated cement spacers for the treatment of infection associated with total hip or knee arthroplasty. J Bone Joint Surg 2007; 89(4)-A: 871-882.
• 3) Masri BA, Duncan CP, Beauchamp CP. Long-term elution of antibiotics from bone-cement: an in vivo study using the prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) system. J Arthroplasty 1998; 13(3): 331-338.
• 4) Stevens CM, Tetsworth KD, Calhoun JH, et al. An articulated antibiotic spacer used for infected total knee arthroplasty: a comparative in vitro elution study of Simplex and Palacos bone cements. J Orthop Res 2005; 23(1): 27-33.
• 5) Hsieh PH, Chang YH, Chen SH, et al. High concentration and bioactivity of vancomycin and aztreonam eluted from Simplex cement spacers in two-stage revision of infected hip implants: a study of 46 patients at an average follow-up of 107 days. J Orthop Res 2006; 24(8): 1615-1621.

Terms in the title (6)： 膝 ,  関節感染症 ,  治療 ,  セメントスペーサー ,  抗菌薬 ,  徐放