Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-γ and TNF-α by Gr-1<sup>+</sup> monocytes

AOYAGI Tetsuji; YAMAMOTO Natsuo; HATTA Masumitsu; TANNO Daiki; MIYAZATO Akiko; ISHII Keiko; SUZUKI Kazuo; NAKAYAMA Toshinori; TANIGUCHI Masaru; KUNISHIMA Hiroyuki; HIRAKATA Yoichi; KAKU Mitsuo; KAWAKAMI Kazuyoshi

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J-GLOBAL ID：201102250999900328 Reference number：11A0988110

Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-γ and TNF-α by Gr-1⁺ monocytes

肺インバリアントNKT細胞の活性化はGr-1⁺単球によるIFN-γ及びTNF-αの局所産生を介してLPSによる急性肺傷害の悪化を招く

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Material：
Volume： 23 Issue： 2 Page： 97-108 Publication year： Feb. 2011
JST Material Number： W0116A ISSN： 0953-8178 Document type： Article
Article type：原著論文 Country of issue： United Kingdom (GBR) Language： ENGLISH (EN)

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Immunological reaction in general , Basic medicine on respiratory system , Cytokines

Reference (57)：

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Tran, T. H., Nguyen, T. L., Nguyen, T. D. et al. 2004. World Health Organization International Avian Influenza Investigative TeamAvian influenza A (H5N1) in 10 patients in Vietnam. N. Engl. J. Med. 350:1179.
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de Jong, M. D., Simmons, C. P., Thanh, T. T. et al. 2006. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat. Med. 12:1203.

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Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-γ and TNF-α by Gr-1+ monocytes

Activation of pulmonary invariant NKT cells leads to exacerbation of acute lung injury caused by LPS through local production of IFN-γ and TNF-α by Gr-1⁺ monocytes