Art

J-GLOBAL ID：201102251016433864   Reference number：11A1058549

l-arginine is effective in stroke-like episodes of MELAS associated with the G13513A mutation

L-アルギニンはG13513A突然変異に関連するMELASの脳卒中様発作に有効である

Author (5)： SHIGEMI Ritsuko (Dep. of Pediatrics, Matsuyama Shimin Hospital, Ohtemachi 2-6-5, Matsuyama, Ehime 791-0067, JPN) ,  FUKUDA Mitsumasa (Dep. of Pediatrics, Ehime Univ. Graduate School of Medicine, Shitsukawa 454, Toon, Ehime 791-0295, JPN) ,  SUZUKI Yuka (Dep. of Pediatrics, Ehime Univ. Graduate School of Medicine, Shitsukawa 454, Toon, Ehime 791-0295, JPN) ,  MORIMOTO Takehiko (Dep. of Pediatrics, Ehime Rehabilitation Center for Children, Tanokubo 1235, Toon, Ehime 791-0212, JPN) ,  ISHII Eiichi (Dep. of Pediatrics, Ehime Univ. Graduate School of Medicine, Shitsukawa 454, Toon, Ehime 791-0295, JPN)
Material： Brain & Development  (Brain & Dev)
Volume： 33  Issue： 6  Page： 518-520  Publication year： Jun. 2011 
JST Material Number： W0814A  ISSN： 0387-7604  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： Mutation ,...
Semi thesaurus term： *genetic variation ,...

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JST classification (3)： Amino acids  (CF10070V) ,  Nervous system diseases  (GN03000O) ,  Congenital diseases,deformities in general.  (GD03010V)

Substance index (1)： Arginine

Reference (10)：

• Koga Y, Ishibashi M, Ueki I, Yatsuga S, Fukiyama R, Akita Y, et al. Effects of L-arginine on the acute phase of strokes in three patients with MELAS. Neurology 2002;58:827-8.
• Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Tanabe Y, et al. L-arginine improves the symptoms of strokelike episodes in MELAS. Neurology 2005;64:710-2.
• Kubota M, Sakakibara Y, Mori M, Yamagata T, Momoi-Yoshida M. Beneficial effect of L-arginine for stroke-like episode in MELAS. Brain Dev 2004;26:481-3.
• Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Fukiyama R, et al. Endothelial dysfunction in MELAS improved by L-arginine supplementation. Neurology 2006;66:1766-9.
• Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Katayama K, et al. MELAS and L-arginine therapy. Mitochondrion 2007;7:133-9.

Terms in the title (4)： L-アルギニン ,  突然変異 ,  MELAS ,  脳卒中様発作