Art

J-GLOBAL ID：201102251870923867   Reference number：11A1907282

Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice

肝細胞においてHIF-1αを破壊すると,食餌で誘導した肥満マウスにおいてグルコース代謝が障害される

Author (12)： OCHIAI Daigo (Dep. of Obstetrics & Gynecology, School of Medicine, Keio Univ., JPN) ,  GODA Nobuhito (Dep. of Life Sci. and Medical BioScience, Waseda Univ. School of Advanced Sci. and Engineering, JPN) ,  GODA Nobuhito (Core Res. for Evolution Sci. and Technol., Japan Sci. and Technol. Agency, TWIns 2-2 Wakamatsu-cho, Shinjuku-ku ...) ,  HISHIKI Takako (Dep. of Biochemistry & Integrative Medical Biology, School of Medicine, Keio Univ., JPN) ,  KANAI Mai (Dep. of Life Sci. and Medical BioScience, Waseda Univ. School of Advanced Sci. and Engineering, JPN) ,  SENOO-MATSUDA Nanami (Dep. of Life Sci. and Medical BioScience, Waseda Univ. School of Advanced Sci. and Engineering, JPN) ,  SENOO-MATSUDA Nanami (Core Res. for Evolution Sci. and Technol., Japan Sci. and Technol. Agency, TWIns 2-2 Wakamatsu-cho, Shinjuku-ku ...) ,  SOGA Tomoyoshi (The Inst. for Advanced Biosciences, Keio Univ., Tsuruoka City, Yamagata 997-0052, JPN) ,  JOHNSON Randall S. (Molecular Biology Section, Div. of Biology, Univ. of California, San Diego, CA 92093, USA) ,  YOSHIMURA Yasunori (Dep. of Obstetrics & Gynecology, School of Medicine, Keio Univ., JPN) ,  SUEMATSU Makoto (Dep. of Biochemistry & Integrative Medical Biology, School of Medicine, Keio Univ., JPN) ,  SUEMATSU Makoto (JST, ERATO, Suematsu Gas Biology Project, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8282, JPN)
Material： Biochemical and Biophysical Research Communications  (BBRC)
Volume： 415  Issue： 3  Page： 445-449  Publication year： Nov. 25, 2011 
JST Material Number： B0118A  ISSN： 0006-291X  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Thesaurus term： *transcription factor ,  gene disruption ,  *carbohydrate metabolism ,  obesity ,  hepatocyte ,  oxygen deficiency ,  dietary effect ,  diabetes mellitus ,  glucokinase
Semi thesaurus term： *HIF-1 alpha ,  *glucose metabolism

JST classification (1)： Metabolism in general  (EB06030E)

Terms in the title (8)： 肝細胞 ,  HIF-1α ,  破壊 ,  食餌 ,  誘導 ,  肥満マウス ,  グルコース代謝 ,  障害